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Article: Abnormal plasma fibrinolysis in patients with rheumatoid arthritis and impaired endothelial fibrinolytic response in those complicated by vasculitis

TitleAbnormal plasma fibrinolysis in patients with rheumatoid arthritis and impaired endothelial fibrinolytic response in those complicated by vasculitis
Authors
Issue Date1993
PublisherB M J Publishing Group. The Journal's web site is located at http://ard.bmjjournals.com/
Citation
Annals Of The Rheumatic Diseases, 1993, v. 52 n. 9, p. 643-649 How to Cite?
AbstractObjectives - (a) To assess plasma fibrinolytic parameters in patients with rheumatoid arthritis (RA) and to determine whether there are differences between patients with RA alone and those with RA complicated by vasculitis. (b) To determine if patients with RA respond differently to venous occlusion compared with normal subjects and to assess whether such a response differs in patients with RA alone and those with rheumatoid vasculitis. (c) To determine the extent of vascular damage in patients with rheumatoid vasculitis and if this correlates with the levels of plasma fibrinolytic parameters. Methods - Sixty three patients with RA (38 had RA only and 25 had evidence of rheumatoid vasculitis) were recruited. Plasma levels of tissue plasminogen activator antigen (t-PA Ag), plasminogen activator inhibitor (PAI) activity, and factor VIII von Willebrand factor (vWF) were measured before and 10 minutes after venous occlusion. Results - Patients with RA, with or without rheumatoid vasculitis, had higher baseline PAI levels than control subjects. The difference was statistically significant for patients with RA alone but was not statistically significant for patients with rheumatoid vasculitis. After venous occlusion, t-PA Ag levels increased significantly in normal subjects and patients with RA alone, but not in patients with rheumatoid vasculitis. Plasma levels of vWF were significantly higher in patients with rheumatoid vasculitis than in normal subjects and those with RA alone. In patients with RA alone, baseline vWF correlated positively with t-PA Ag levels, whereas a negative correlation was found between these two parameters in patients with rheumatoid vasculitis. A negative correlation between vWF and t-PA Ag levels after venous occlusion was also found in patients with rheumatoid vasculitis. Conclusions - Patients with rheumatoid vasculitis showed evidence of vascular damage with increased levels of vWF and impaired t-PA Ag release after venous occlusion, a useful measurement of endothelial reserve to remove fibrin. This may be of pathophysiological importance in the development of vasculitis in these patients.
Persistent Identifierhttp://hdl.handle.net/10722/161966
ISSN
2015 Impact Factor: 12.384
2015 SCImago Journal Rankings: 4.537
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLau, CSen_US
dc.contributor.authorMclaren, Men_US
dc.contributor.authorHanslip, Jen_US
dc.contributor.authorKerr, Men_US
dc.contributor.authorBelch, JJFen_US
dc.date.accessioned2012-09-05T05:16:21Z-
dc.date.available2012-09-05T05:16:21Z-
dc.date.issued1993en_US
dc.identifier.citationAnnals Of The Rheumatic Diseases, 1993, v. 52 n. 9, p. 643-649en_US
dc.identifier.issn0003-4967en_US
dc.identifier.urihttp://hdl.handle.net/10722/161966-
dc.description.abstractObjectives - (a) To assess plasma fibrinolytic parameters in patients with rheumatoid arthritis (RA) and to determine whether there are differences between patients with RA alone and those with RA complicated by vasculitis. (b) To determine if patients with RA respond differently to venous occlusion compared with normal subjects and to assess whether such a response differs in patients with RA alone and those with rheumatoid vasculitis. (c) To determine the extent of vascular damage in patients with rheumatoid vasculitis and if this correlates with the levels of plasma fibrinolytic parameters. Methods - Sixty three patients with RA (38 had RA only and 25 had evidence of rheumatoid vasculitis) were recruited. Plasma levels of tissue plasminogen activator antigen (t-PA Ag), plasminogen activator inhibitor (PAI) activity, and factor VIII von Willebrand factor (vWF) were measured before and 10 minutes after venous occlusion. Results - Patients with RA, with or without rheumatoid vasculitis, had higher baseline PAI levels than control subjects. The difference was statistically significant for patients with RA alone but was not statistically significant for patients with rheumatoid vasculitis. After venous occlusion, t-PA Ag levels increased significantly in normal subjects and patients with RA alone, but not in patients with rheumatoid vasculitis. Plasma levels of vWF were significantly higher in patients with rheumatoid vasculitis than in normal subjects and those with RA alone. In patients with RA alone, baseline vWF correlated positively with t-PA Ag levels, whereas a negative correlation was found between these two parameters in patients with rheumatoid vasculitis. A negative correlation between vWF and t-PA Ag levels after venous occlusion was also found in patients with rheumatoid vasculitis. Conclusions - Patients with rheumatoid vasculitis showed evidence of vascular damage with increased levels of vWF and impaired t-PA Ag release after venous occlusion, a useful measurement of endothelial reserve to remove fibrin. This may be of pathophysiological importance in the development of vasculitis in these patients.en_US
dc.languageengen_US
dc.publisherB M J Publishing Group. The Journal's web site is located at http://ard.bmjjournals.com/en_US
dc.relation.ispartofAnnals of the Rheumatic Diseasesen_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshArthritis, Rheumatoid - Blood - Complicationsen_US
dc.subject.meshConstriction, Pathologic - Blooden_US
dc.subject.meshEndothelium, Vascular - Physiopathologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshFibrinolysis - Physiologyen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshPeripheral Vascular Diseases - Blooden_US
dc.subject.meshPlasminogen Inactivators - Blooden_US
dc.subject.meshTissue Plasminogen Activator - Blooden_US
dc.subject.meshVasculitis - Blood - Etiology - Physiopathologyen_US
dc.subject.meshVon Willebrand Factor - Analysisen_US
dc.titleAbnormal plasma fibrinolysis in patients with rheumatoid arthritis and impaired endothelial fibrinolytic response in those complicated by vasculitisen_US
dc.typeArticleen_US
dc.identifier.emailLau, CS:cslau@hku.hken_US
dc.identifier.authorityLau, CS=rp01348en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1136/ard.52.9.643-
dc.identifier.pmid8239758-
dc.identifier.scopuseid_2-s2.0-0027185328en_US
dc.identifier.volume52en_US
dc.identifier.issue9en_US
dc.identifier.spage643en_US
dc.identifier.epage649en_US
dc.identifier.isiWOS:A1993LY74900004-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridLau, CS=14035682100en_US
dc.identifier.scopusauthoridMcLaren, M=7005471705en_US
dc.identifier.scopusauthoridHanslip, J=6602729754en_US
dc.identifier.scopusauthoridKerr, M=7202504685en_US
dc.identifier.scopusauthoridBelch, JJF=7101752870en_US

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