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Article: Effect of epidermal growth factor on gastric blood flow in rats: Possible role in mucosal protection

TitleEffect of epidermal growth factor on gastric blood flow in rats: Possible role in mucosal protection
Authors
Issue Date1993
PublisherWB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/gastro
Citation
Gastroenterology, 1993, v. 104 n. 6, p. 1605-1610 How to Cite?
AbstractBackground: The mechanism by which epidermal growth factor (EGF) protects the gastric mucosa against injury is unclear. Whether EGF has any effect on gastric blood flow has not been reported. Methods: Using an ex vivo gastric chamber preparation, the effect of EGF on gastric blood flow in rats was studied by laser Doppler flowmetry. Measurements of blood flow and mucosal damage were made in both intact and sialoadenectomized rats with graded doses of EGF at basal condition and after topical application of absolute ethanol. Results: Sialoadenectomy alone increased ethanol-induced gastric mucosal lesions (P < 0.05) but had no significant effect on blood flow. EGF pretreatment resulted in both a reduction in ethanol-induced gastric mucosal injury as well as a significant increase in blood flow compared with controls (both P < 0.05). Graded doses of EGF (3.12-25 μg) resulted in an dose- dependent increase in gastric blood flow (r = 0.68; P < 0.001), which correlated inversely with the degree of mucosal damage (r = -0.72; P < 0.001). Conclusions: Mucosal protection by EGF is accompanied by an increase in gastric blood flow; this action may contribute to its mucosal protective effect.
Persistent Identifierhttp://hdl.handle.net/10722/161962
ISSN
2015 Impact Factor: 18.187
2015 SCImago Journal Rankings: 7.170
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorWai Mo Huien_US
dc.contributor.authorBao Wen Chenen_US
dc.contributor.authorKung, AWCen_US
dc.contributor.authorChi Hin Choen_US
dc.contributor.authorChiu Tong Luken_US
dc.contributor.authorShiu Kum Lamen_US
dc.date.accessioned2012-09-05T05:16:19Z-
dc.date.available2012-09-05T05:16:19Z-
dc.date.issued1993en_US
dc.identifier.citationGastroenterology, 1993, v. 104 n. 6, p. 1605-1610en_US
dc.identifier.issn0016-5085en_US
dc.identifier.urihttp://hdl.handle.net/10722/161962-
dc.description.abstractBackground: The mechanism by which epidermal growth factor (EGF) protects the gastric mucosa against injury is unclear. Whether EGF has any effect on gastric blood flow has not been reported. Methods: Using an ex vivo gastric chamber preparation, the effect of EGF on gastric blood flow in rats was studied by laser Doppler flowmetry. Measurements of blood flow and mucosal damage were made in both intact and sialoadenectomized rats with graded doses of EGF at basal condition and after topical application of absolute ethanol. Results: Sialoadenectomy alone increased ethanol-induced gastric mucosal lesions (P < 0.05) but had no significant effect on blood flow. EGF pretreatment resulted in both a reduction in ethanol-induced gastric mucosal injury as well as a significant increase in blood flow compared with controls (both P < 0.05). Graded doses of EGF (3.12-25 μg) resulted in an dose- dependent increase in gastric blood flow (r = 0.68; P < 0.001), which correlated inversely with the degree of mucosal damage (r = -0.72; P < 0.001). Conclusions: Mucosal protection by EGF is accompanied by an increase in gastric blood flow; this action may contribute to its mucosal protective effect.en_US
dc.languageengen_US
dc.publisherWB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/gastroen_US
dc.relation.ispartofGastroenterologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshBlood Flow Velocity - Drug Effectsen_US
dc.subject.meshEpidermal Growth Factor - Pharmacologyen_US
dc.subject.meshEthanol - Toxicityen_US
dc.subject.meshGastric Acid - Secretionen_US
dc.subject.meshGastric Mucosa - Blood Supply - Drug Effectsen_US
dc.subject.meshMaleen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Sprague-Dawleyen_US
dc.subject.meshRegional Blood Flow - Drug Effectsen_US
dc.subject.meshSubmandibular Gland - Surgeryen_US
dc.titleEffect of epidermal growth factor on gastric blood flow in rats: Possible role in mucosal protectionen_US
dc.typeArticleen_US
dc.identifier.emailKung, AWC:awckung@hku.hken_US
dc.identifier.authorityKung, AWC=rp00368en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid8500716-
dc.identifier.scopuseid_2-s2.0-0027164831en_US
dc.identifier.volume104en_US
dc.identifier.issue6en_US
dc.identifier.spage1605en_US
dc.identifier.epage1610en_US
dc.identifier.isiWOS:A1993LE46800003-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridWai Mo Hui=7409779346en_US
dc.identifier.scopusauthoridBao Wen Chen=7409682408en_US
dc.identifier.scopusauthoridKung, AWC=7102322339en_US
dc.identifier.scopusauthoridChi Hin Cho=7409803382en_US
dc.identifier.scopusauthoridChiu Tong Luk=7409628513en_US
dc.identifier.scopusauthoridShiu Kum Lam=7409550162en_US

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