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Article: Dipyridamole increases human red blood cell deformability

TitleDipyridamole increases human red blood cell deformability
Authors
Issue Date1992
PublisherSpringer Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/00228/index.htm
Citation
European Journal Of Clinical Pharmacology, 1992, v. 42 n. 6, p. 651-654 How to Cite?
AbstractAn automated filtration technique has been used to investigate the effect of dipyridamole (DP) on red blood cell deformability in patients identified as having rigid red cells. They were patients on haemodialysis (HD) for chronic renal failure (n = 18), patients with peripheral vascular disease (PVD, n = 23) and controls (hospital out-patients, n = 33). Leucocytes and platelets were removed from heparinised blood by filtration through Imugard wool. Washed red cell suspensions in buffer at 5% haematocrit, without or with 5 μM DP, were filtered through Nuclepore Hemafil Membranes with 4.7 μm pores. The initial steady state relative filtration pressure (iRFP) was used to assess cell deformability. A low iRFP value reflects increased deformability and vice versa. The mean iRFP values were 0.33, 0.393 and 0.403 for controls, PVD and HD patients respectively, indicating that the red cells in the two groups of patients were significantly more rigid. DP reduced the iRFP to 0.266, 0.278 and 0.263 for controls, PVD and HD patients respectively. The results suggest that DP may be beneficial when red cell rigidity contributes to impaired microvascular perfusion.
Persistent Identifierhttp://hdl.handle.net/10722/161955
ISSN
2015 Impact Factor: 2.71
2015 SCImago Journal Rankings: 1.096
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorSaniabadi, ARen_US
dc.contributor.authorFisher, TCen_US
dc.contributor.authorLau, CSen_US
dc.contributor.authorBridges, Aen_US
dc.contributor.authorTaylor, Jen_US
dc.contributor.authorBelch, Jen_US
dc.contributor.authorForbes, CDen_US
dc.date.accessioned2012-09-05T05:16:17Z-
dc.date.available2012-09-05T05:16:17Z-
dc.date.issued1992en_US
dc.identifier.citationEuropean Journal Of Clinical Pharmacology, 1992, v. 42 n. 6, p. 651-654en_US
dc.identifier.issn0031-6970en_US
dc.identifier.urihttp://hdl.handle.net/10722/161955-
dc.description.abstractAn automated filtration technique has been used to investigate the effect of dipyridamole (DP) on red blood cell deformability in patients identified as having rigid red cells. They were patients on haemodialysis (HD) for chronic renal failure (n = 18), patients with peripheral vascular disease (PVD, n = 23) and controls (hospital out-patients, n = 33). Leucocytes and platelets were removed from heparinised blood by filtration through Imugard wool. Washed red cell suspensions in buffer at 5% haematocrit, without or with 5 μM DP, were filtered through Nuclepore Hemafil Membranes with 4.7 μm pores. The initial steady state relative filtration pressure (iRFP) was used to assess cell deformability. A low iRFP value reflects increased deformability and vice versa. The mean iRFP values were 0.33, 0.393 and 0.403 for controls, PVD and HD patients respectively, indicating that the red cells in the two groups of patients were significantly more rigid. DP reduced the iRFP to 0.266, 0.278 and 0.263 for controls, PVD and HD patients respectively. The results suggest that DP may be beneficial when red cell rigidity contributes to impaired microvascular perfusion.en_US
dc.languageengen_US
dc.publisherSpringer Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/00228/index.htmen_US
dc.relation.ispartofEuropean Journal of Clinical Pharmacologyen_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshDipyridamole - Pharmacologyen_US
dc.subject.meshErythrocyte Deformability - Drug Effectsen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshKidney Failure, Chronic - Blooden_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshPeripheral Vascular Diseases - Blooden_US
dc.subject.meshRenal Dialysisen_US
dc.titleDipyridamole increases human red blood cell deformabilityen_US
dc.typeArticleen_US
dc.identifier.emailLau, CS:cslau@hku.hken_US
dc.identifier.authorityLau, CS=rp01348en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid1623907-
dc.identifier.scopuseid_2-s2.0-0026776311en_US
dc.identifier.volume42en_US
dc.identifier.issue6en_US
dc.identifier.spage651en_US
dc.identifier.epage654en_US
dc.identifier.isiWOS:A1992JD50800016-
dc.publisher.placeGermanyen_US
dc.identifier.scopusauthoridSaniabadi, AR=18936909200en_US
dc.identifier.scopusauthoridFisher, TC=7202246856en_US
dc.identifier.scopusauthoridLau, CS=14035682100en_US
dc.identifier.scopusauthoridBridges, A=8903578700en_US
dc.identifier.scopusauthoridTaylor, J=7405402501en_US
dc.identifier.scopusauthoridBelch, J=7101752869en_US
dc.identifier.scopusauthoridForbes, CD=7103200092en_US

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