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Article: Effects of allopurinol on reperfusion arrhythmias in isolated ventricles

TitleEffects of allopurinol on reperfusion arrhythmias in isolated ventricles
Authors
Issue Date1992
PublisherAmerican Physiological Society. The Journal's web site is located at http://ajpcon.physiology.org/
Citation
American Journal Of Physiology - Heart And Circulatory Physiology, 1992, v. 263 n. 2 32-2, p. H341-H348 How to Cite?
AbstractElectrophysiological effects of allopurinol on arrhythmias were studied in isolated segments of guinea pig right ventricular free walls paced from endocardium. A high-gain electrocardiogram as well as transmembrane electrical activity from endo- and epicardium were recorded. Tissues were exposed to simulated ischemia for 15 min and then were reperfused with normal Tyrode solution. Sustained or nonsustained ventricular tachycardia, bigeminy, and trigeminy with characteristics of transmural reentry occurred in early reperfusion in 75% of 20 control preparations. Arrhythmias were associated with prolongation of transmural conduction time and abbreviation of endocardial effective refractory period (ERP). Allopurinol strongly reduced the incidence of reperfusion arrhythmias (20-33%) between 10 and 100 μM, whereas either lower or higher concentrations (5 or 500 μM) were less effective (43 and 50%). Antiarrhythmic efficacy correlated with significant attenuation of reperfusion-induced transmural conduction delay (P < 0.05 or 0.01). Allopurinol did not affect endocardial conduction times nor did it significantly alter endocardial action potential duration or ERP. Our results indicate that allopurinol exerts antiarrhythmic efficacy during reperfusion by selectively attenuating defects related to anisotropic tissue properties.
Persistent Identifierhttp://hdl.handle.net/10722/161950
ISSN
1998 Impact Factor: 3.077
2004 SCImago Journal Rankings: 1.102
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLi, GRen_US
dc.contributor.authorFerrier, GRen_US
dc.date.accessioned2012-09-05T05:16:14Z-
dc.date.available2012-09-05T05:16:14Z-
dc.date.issued1992en_US
dc.identifier.citationAmerican Journal Of Physiology - Heart And Circulatory Physiology, 1992, v. 263 n. 2 32-2, p. H341-H348en_US
dc.identifier.issn0002-9513en_US
dc.identifier.urihttp://hdl.handle.net/10722/161950-
dc.description.abstractElectrophysiological effects of allopurinol on arrhythmias were studied in isolated segments of guinea pig right ventricular free walls paced from endocardium. A high-gain electrocardiogram as well as transmembrane electrical activity from endo- and epicardium were recorded. Tissues were exposed to simulated ischemia for 15 min and then were reperfused with normal Tyrode solution. Sustained or nonsustained ventricular tachycardia, bigeminy, and trigeminy with characteristics of transmural reentry occurred in early reperfusion in 75% of 20 control preparations. Arrhythmias were associated with prolongation of transmural conduction time and abbreviation of endocardial effective refractory period (ERP). Allopurinol strongly reduced the incidence of reperfusion arrhythmias (20-33%) between 10 and 100 μM, whereas either lower or higher concentrations (5 or 500 μM) were less effective (43 and 50%). Antiarrhythmic efficacy correlated with significant attenuation of reperfusion-induced transmural conduction delay (P < 0.05 or 0.01). Allopurinol did not affect endocardial conduction times nor did it significantly alter endocardial action potential duration or ERP. Our results indicate that allopurinol exerts antiarrhythmic efficacy during reperfusion by selectively attenuating defects related to anisotropic tissue properties.en_US
dc.languageengen_US
dc.publisherAmerican Physiological Society. The Journal's web site is located at http://ajpcon.physiology.org/en_US
dc.relation.ispartofAmerican Journal of Physiology - Heart and Circulatory Physiologyen_US
dc.subject.meshAction Potentialsen_US
dc.subject.meshAllopurinol - Pharmacologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshArrhythmias, Cardiac - Prevention & Controlen_US
dc.subject.meshCoronary Disease - Physiopathologyen_US
dc.subject.meshElectrophysiologyen_US
dc.subject.meshGuinea Pigsen_US
dc.subject.meshHeart - Drug Effects - Physiopathologyen_US
dc.subject.meshHeart Conduction System - Drug Effects - Physiopathologyen_US
dc.subject.meshMaleen_US
dc.subject.meshMyocardial Reperfusion Injury - Prevention & Controlen_US
dc.subject.meshPericardium - Physiopathologyen_US
dc.subject.meshReaction Timeen_US
dc.subject.meshRefractory Period, Electrophysiologicalen_US
dc.subject.meshReperfusionen_US
dc.titleEffects of allopurinol on reperfusion arrhythmias in isolated ventriclesen_US
dc.typeArticleen_US
dc.identifier.emailLi, GR:grli@hkucc.hku.hken_US
dc.identifier.authorityLi, GR=rp00476en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid1510130en_US
dc.identifier.scopuseid_2-s2.0-0026759491en_US
dc.identifier.volume263en_US
dc.identifier.issue2 32-2en_US
dc.identifier.spageH341en_US
dc.identifier.epageH348en_US
dc.identifier.isiWOS:A1992JJ96000006-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridLi, GR=7408462932en_US
dc.identifier.scopusauthoridFerrier, GR=7005858840en_US

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