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Article: Clonal evolution in primary 5q- syndrome

TitleClonal evolution in primary 5q- syndrome
Authors
Wong, KFChan, JKCChu, YCKwong, YL
Keywords5q—syndrome
acute leukemia
clonal evolution
myelodysplastic syndrome
Issue Date1992
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/28741
Citation
Cancer, 1992, v. 70 n. 1, p. 100-103 How to Cite?
DOI: http://dx.doi.org/10.1002/1097-0142(19920701)70:1<100::AID-CNCR2820700116>3.0.CO;2-F
AbstractPrimary 5q- syndrome is a type of myelodysplastic syndrome characterized by refractory anemia, thrombocytosis, and hypolobulated megakaryocytes. The risk of leukemic transformation is low. A case of 5q- syndrome that occurred in a 42-year-old woman and was complicated by leukemic transformation 7 years after the initial diagnosis is reported. An additional clonal karyotypic anomaly, del(7q), was seen in the leukemic cells. The literature on leukemic and karyotypic evolution of primary 5q- syndrome is reviewed and the implication of karyotypic evolution is discussed.
Persistent Identifierhttp://hdl.handle.net/10722/161941
ISSN
0008-543X
2021 Impact Factor: 6.921
2020 SCImago Journal Rankings: 3.052
ISI Accession Number ID
WOS:A1992HZ75800015

 

DC FieldValueLanguage
dc.contributor.authorWong, KFen_US
dc.contributor.authorChan, JKCen_US
dc.contributor.authorChu, YCen_US
dc.contributor.authorKwong, YLen_US
dc.date.accessioned2012-09-05T05:16:11Z-
dc.date.available2012-09-05T05:16:11Z-
dc.date.issued1992en_US
dc.identifier.citationCancer, 1992, v. 70 n. 1, p. 100-103en_US
dc.identifier.issn0008-543Xen_US
dc.identifier.urihttp://hdl.handle.net/10722/161941-
dc.description.abstractPrimary 5q- syndrome is a type of myelodysplastic syndrome characterized by refractory anemia, thrombocytosis, and hypolobulated megakaryocytes. The risk of leukemic transformation is low. A case of 5q- syndrome that occurred in a 42-year-old woman and was complicated by leukemic transformation 7 years after the initial diagnosis is reported. An additional clonal karyotypic anomaly, del(7q), was seen in the leukemic cells. The literature on leukemic and karyotypic evolution of primary 5q- syndrome is reviewed and the implication of karyotypic evolution is discussed.en_US
dc.languageengen_US
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/28741en_US
dc.relation.ispartofCanceren_US
dc.subject5q—syndrome-
dc.subjectacute leukemia-
dc.subjectclonal evolution-
dc.subjectmyelodysplastic syndrome-
dc.subject.meshAcute Diseaseen_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshAged, 80 And Overen_US
dc.subject.meshCell Transformation, Neoplastic - Geneticsen_US
dc.subject.meshChromosome Aberrationsen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshKaryotypingen_US
dc.subject.meshLeukemia - Etiology - Geneticsen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshMyelodysplastic Syndromes - Complications - Geneticsen_US
dc.titleClonal evolution in primary 5q- syndromeen_US
dc.typeArticleen_US
dc.identifier.emailKwong, YL:ylkwong@hku.hken_US
dc.identifier.authorityKwong, YL=rp00358en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1002/1097-0142(19920701)70:1<100::AID-CNCR2820700116>3.0.CO;2-Fen_US
dc.identifier.pmid1606529-
dc.identifier.scopuseid_2-s2.0-0026695279en_US
dc.identifier.volume70en_US
dc.identifier.issue1en_US
dc.identifier.spage100en_US
dc.identifier.epage103en_US
dc.identifier.isiWOS:A1992HZ75800015-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridWong, KF=7404759860en_US
dc.identifier.scopusauthoridChan, JKC=7403287069en_US
dc.identifier.scopusauthoridChu, YC=55209144200en_US
dc.identifier.scopusauthoridKwong, YL=7102818954en_US
dc.identifier.issnl0008-543X-

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