File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Verapamil prevents slowing of transmural conduction and suppresses arrhythmias in an isolated guinea pig ventricular model of ischemia and reperfusion

TitleVerapamil prevents slowing of transmural conduction and suppresses arrhythmias in an isolated guinea pig ventricular model of ischemia and reperfusion
Authors
Issue Date1992
PublisherLippincott Williams & Wilkins. The Journal's web site is located at http://circres.ahajournals.org
Citation
Circulation Research, 1992, v. 70 n. 4, p. 651-659 How to Cite?
AbstractTransmembrane electrical activity was recorded from endocardium and epicardium of isolated segments of guinea pig right ventricular free walls. An electrocardiogram was recorded by electrodes at opposite ends of the tissue bath. Endocardium was stimulated. Tissues were exposed to 'ischemic' conditions (e.g., acidosis, hyperkalemia, hypoxia, and lactate) for 15 minutes and then were reperfused with 'normal' Tyrode's solution. Arrhythmias with characteristics of transmural reentry occurred in ischemic conditions and early reperfusion in 30% and 70% of 20 control hearts, respectively. Arrhythmias were associated with prolongation of transmural conduction time (CT) and abbreviation of endocardial effective refractory period. Verapamil significantly suppressed reperfusion arrhythmias at 0.1-1.0 μM but not at 3.0 μM. Verapamil also significantly decreased the incidence of arrhythmias during ischemic conditions at 0.5 μM but significantly promoted ischemic arrhythmias at 3.0 μM. Action potential duration and effective refractory period were not altered by verapamil during ischemic conditions or reperfusion. However, at 0.1-1.0 μM, verapamil prevented or attenuated prolongation of transmural CT by ischemic conditions and reperfusion. Transmural CT was further prolonged at 3 μM verapamil. In epicardial slices, 1 μM verapamil shortened CT transverse to fiber orientation during reperfusion but had no effect on longitudinal CT. Our results indicate that verapamil may suppress arrhythmias through differential effects on CT transverse and longitudinal to fiber orientation in anisotropic ventricular tissues and thus by specifically improving transmural conduction.
Persistent Identifierhttp://hdl.handle.net/10722/161935
ISSN
2015 Impact Factor: 11.551
2015 SCImago Journal Rankings: 5.755
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLi, GRen_US
dc.contributor.authorFerrier, GRen_US
dc.date.accessioned2012-09-05T05:16:08Z-
dc.date.available2012-09-05T05:16:08Z-
dc.date.issued1992en_US
dc.identifier.citationCirculation Research, 1992, v. 70 n. 4, p. 651-659en_US
dc.identifier.issn0009-7330en_US
dc.identifier.urihttp://hdl.handle.net/10722/161935-
dc.description.abstractTransmembrane electrical activity was recorded from endocardium and epicardium of isolated segments of guinea pig right ventricular free walls. An electrocardiogram was recorded by electrodes at opposite ends of the tissue bath. Endocardium was stimulated. Tissues were exposed to 'ischemic' conditions (e.g., acidosis, hyperkalemia, hypoxia, and lactate) for 15 minutes and then were reperfused with 'normal' Tyrode's solution. Arrhythmias with characteristics of transmural reentry occurred in ischemic conditions and early reperfusion in 30% and 70% of 20 control hearts, respectively. Arrhythmias were associated with prolongation of transmural conduction time (CT) and abbreviation of endocardial effective refractory period. Verapamil significantly suppressed reperfusion arrhythmias at 0.1-1.0 μM but not at 3.0 μM. Verapamil also significantly decreased the incidence of arrhythmias during ischemic conditions at 0.5 μM but significantly promoted ischemic arrhythmias at 3.0 μM. Action potential duration and effective refractory period were not altered by verapamil during ischemic conditions or reperfusion. However, at 0.1-1.0 μM, verapamil prevented or attenuated prolongation of transmural CT by ischemic conditions and reperfusion. Transmural CT was further prolonged at 3 μM verapamil. In epicardial slices, 1 μM verapamil shortened CT transverse to fiber orientation during reperfusion but had no effect on longitudinal CT. Our results indicate that verapamil may suppress arrhythmias through differential effects on CT transverse and longitudinal to fiber orientation in anisotropic ventricular tissues and thus by specifically improving transmural conduction.en_US
dc.languageengen_US
dc.publisherLippincott Williams & Wilkins. The Journal's web site is located at http://circres.ahajournals.orgen_US
dc.relation.ispartofCirculation Researchen_US
dc.subject.meshAction Potentialsen_US
dc.subject.meshAnimalsen_US
dc.subject.meshArrhythmias, Cardiac - Physiopathology - Prevention & Controlen_US
dc.subject.meshElectrocardiographyen_US
dc.subject.meshGuinea Pigsen_US
dc.subject.meshHeart Conduction System - Drug Effects - Physiopathologyen_US
dc.subject.meshMaleen_US
dc.subject.meshMyocardial Reperfusion Injury - Prevention & Controlen_US
dc.subject.meshTime Factorsen_US
dc.subject.meshVerapamil - Pharmacologyen_US
dc.titleVerapamil prevents slowing of transmural conduction and suppresses arrhythmias in an isolated guinea pig ventricular model of ischemia and reperfusionen_US
dc.typeArticleen_US
dc.identifier.emailLi, GR:grli@hkucc.hku.hken_US
dc.identifier.authorityLi, GR=rp00476en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid1551192-
dc.identifier.scopuseid_2-s2.0-0026609105en_US
dc.identifier.volume70en_US
dc.identifier.issue4en_US
dc.identifier.spage651en_US
dc.identifier.epage659en_US
dc.identifier.isiWOS:A1992HL57600004-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridLi, GR=7408462932en_US
dc.identifier.scopusauthoridFerrier, GR=7005858840en_US

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats