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Article: White blood cell activation in Raynaud's phenomenon of systemic sclerosis and vibration induced white finger syndrome

TitleWhite blood cell activation in Raynaud's phenomenon of systemic sclerosis and vibration induced white finger syndrome
Authors
Issue Date1992
PublisherB M J Publishing Group. The Journal's web site is located at http://ard.bmjjournals.com/
Citation
Annals Of The Rheumatic Diseases, 1992, v. 51 n. 2, p. 249-252 How to Cite?
AbstractSystemic sclerosis (SSc) and vibration induced white finger syndrome (VWF) are common causes of secondary Raynaud's phenomenon. Previous studies have suggested an increase in inflammation in patients with SSc. Vibration induced white finger syndrome occurs in workers exposed to vibration and is now a prescribed disease. In VWF, although it is recognised that vibration can cause direct damage to blood vessels, it does not explain why only some workers are affected. It is possible that an inflammatory process develops in these patients in the same way as is seen in SSc. Leukotriene B4, produced mainly by polymorphonuclear cells, is a potent mediator of inflammation. The plasma thiol concentration shows the degree of oxidation of plasma and a decreased concentration indicates the increased production of free radicals which are capable of oxidative damage. In this work, the white blood cell (WBC) production of leukotriene B4 and plasma thiol concentrations were measured in patients with SSc and VWF. Fifty nine patients were studied: 34 had SSc and 25 had VWF. The results were compared with 25 matched normal controls and are expressed as the median and range. After stimulation of the polymorphonuclear cells with calcium ionophore A23187 (1 μg/ml), patients with SSc and VWF were found to have significantly increased leukotriene B4 production (23.5 (14.4-44.0) and 26 (14.4-39.4) ng/106 cells, respectively) compared with normal controls (17.2 (6.0-38.0) ng/106 cells). The plasma thiol concentration was shown to be significantly lower in patients with SSc and VWF (445 (375-475) and 450 (417-510) μmol/l, respectively) compared with normal controls (480 (418-555) μmol/l). Our results show increased leukotriene B4 production and increased free radical activity in patients with SSc and VWF. Although previous indirect evidence has suggested increased WBC activity in patients with SSc, this is reported directly here for the first time. In addition, the possibility of an inflammatory process occurring in patients with VWF, as shown here, has not previously been studied. This may be a further mechanism to explain the poor circulation in the fingers of these patients.
Persistent Identifierhttp://hdl.handle.net/10722/161930
ISSN
2015 Impact Factor: 12.384
2015 SCImago Journal Rankings: 4.537
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLau, CSen_US
dc.contributor.authorO'dowd, Aen_US
dc.contributor.authorBelch, JJFen_US
dc.date.accessioned2012-09-05T05:16:06Z-
dc.date.available2012-09-05T05:16:06Z-
dc.date.issued1992en_US
dc.identifier.citationAnnals Of The Rheumatic Diseases, 1992, v. 51 n. 2, p. 249-252en_US
dc.identifier.issn0003-4967en_US
dc.identifier.urihttp://hdl.handle.net/10722/161930-
dc.description.abstractSystemic sclerosis (SSc) and vibration induced white finger syndrome (VWF) are common causes of secondary Raynaud's phenomenon. Previous studies have suggested an increase in inflammation in patients with SSc. Vibration induced white finger syndrome occurs in workers exposed to vibration and is now a prescribed disease. In VWF, although it is recognised that vibration can cause direct damage to blood vessels, it does not explain why only some workers are affected. It is possible that an inflammatory process develops in these patients in the same way as is seen in SSc. Leukotriene B4, produced mainly by polymorphonuclear cells, is a potent mediator of inflammation. The plasma thiol concentration shows the degree of oxidation of plasma and a decreased concentration indicates the increased production of free radicals which are capable of oxidative damage. In this work, the white blood cell (WBC) production of leukotriene B4 and plasma thiol concentrations were measured in patients with SSc and VWF. Fifty nine patients were studied: 34 had SSc and 25 had VWF. The results were compared with 25 matched normal controls and are expressed as the median and range. After stimulation of the polymorphonuclear cells with calcium ionophore A23187 (1 μg/ml), patients with SSc and VWF were found to have significantly increased leukotriene B4 production (23.5 (14.4-44.0) and 26 (14.4-39.4) ng/106 cells, respectively) compared with normal controls (17.2 (6.0-38.0) ng/106 cells). The plasma thiol concentration was shown to be significantly lower in patients with SSc and VWF (445 (375-475) and 450 (417-510) μmol/l, respectively) compared with normal controls (480 (418-555) μmol/l). Our results show increased leukotriene B4 production and increased free radical activity in patients with SSc and VWF. Although previous indirect evidence has suggested increased WBC activity in patients with SSc, this is reported directly here for the first time. In addition, the possibility of an inflammatory process occurring in patients with VWF, as shown here, has not previously been studied. This may be a further mechanism to explain the poor circulation in the fingers of these patients.en_US
dc.languageengen_US
dc.publisherB M J Publishing Group. The Journal's web site is located at http://ard.bmjjournals.com/en_US
dc.relation.ispartofAnnals of the Rheumatic Diseasesen_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshFemaleen_US
dc.subject.meshFree Radicals - Metabolismen_US
dc.subject.meshHumansen_US
dc.subject.meshLeukocytes - Metabolismen_US
dc.subject.meshLeukotriene B4 - Biosynthesisen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshOccupational Diseases - Metabolismen_US
dc.subject.meshRaynaud Disease - Etiology - Metabolismen_US
dc.subject.meshScleroderma, Systemic - Metabolismen_US
dc.subject.meshSulfhydryl Compounds - Blooden_US
dc.subject.meshVibration - Adverse Effectsen_US
dc.titleWhite blood cell activation in Raynaud's phenomenon of systemic sclerosis and vibration induced white finger syndromeen_US
dc.typeArticleen_US
dc.identifier.emailLau, CS:cslau@hku.hken_US
dc.identifier.authorityLau, CS=rp01348en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1136/ard.51.2.249-
dc.identifier.pmid1312815-
dc.identifier.scopuseid_2-s2.0-0026575126en_US
dc.identifier.volume51en_US
dc.identifier.issue2en_US
dc.identifier.spage249en_US
dc.identifier.epage252en_US
dc.identifier.isiWOS:A1992HE52400022-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridLau, CS=14035682100en_US
dc.identifier.scopusauthoridO'Dowd, A=7102128441en_US
dc.identifier.scopusauthoridBelch, JJF=7101752870en_US

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