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Article: Effects of α-interferon and prednisone on serum-soluble interleukin-2 receptor (sIL-2R) in chronic hepatitis B infection

TitleEffects of α-interferon and prednisone on serum-soluble interleukin-2 receptor (sIL-2R) in chronic hepatitis B infection
Authors
Issue Date1992
PublisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/ajg/index.html
Citation
American Journal Of Gastroenterology, 1992, v. 87 n. 1, p. 113-117 How to Cite?
AbstractThe level of serum-soluble interleukin-2 receptor (sIL-2R) was measured in 32 patients to investigate the effect of prednisone and α-interferon therapy on chronic hepatitis B virus infection. All the patients were seropositive for hepatitis B surface antigen and hepatitis B e antigen, with histological evidence of chronic persistent or chronic active hepatitis. Twenty-six patients received oral prednisone, followed by subcutaneous recombinant α- interferon, and six patients received multivitamin tablets and served as controls. After 4 wk of prednisone in reducing dosage, serum sIL-2R fell significantly from 673.6 ± 52.9 U/ml to 584.8 ± 39.4 U/ml (mean ± SE, p < 0.05). It rose to 733.4 ± 45.7 U/ml (p < 0.05) on the 4th wk of interferon, but returned to pretreatment level at completion of interferon. There was a significant correlation between serum sIL-2R and alanine aminotransferase levels (r = 0.36, p < 0.001). The level of serum sIL-2R before treatment and its response to prednisone and interferon were not useful in predicting seroconversion of hepatitis B e antigen and anti-hepatitis B e.
Persistent Identifierhttp://hdl.handle.net/10722/161927
ISSN
2015 Impact Factor: 10.383
2015 SCImago Journal Rankings: 3.946
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLeung, NWYen_HK
dc.contributor.authorLeung, JCKen_HK
dc.contributor.authorTam, JSen_HK
dc.contributor.authorLau, JTFen_HK
dc.contributor.authorKar Neng Laien_HK
dc.date.accessioned2012-09-05T05:16:05Z-
dc.date.available2012-09-05T05:16:05Z-
dc.date.issued1992en_HK
dc.identifier.citationAmerican Journal Of Gastroenterology, 1992, v. 87 n. 1, p. 113-117en_HK
dc.identifier.issn0002-9270en_HK
dc.identifier.urihttp://hdl.handle.net/10722/161927-
dc.description.abstractThe level of serum-soluble interleukin-2 receptor (sIL-2R) was measured in 32 patients to investigate the effect of prednisone and α-interferon therapy on chronic hepatitis B virus infection. All the patients were seropositive for hepatitis B surface antigen and hepatitis B e antigen, with histological evidence of chronic persistent or chronic active hepatitis. Twenty-six patients received oral prednisone, followed by subcutaneous recombinant α- interferon, and six patients received multivitamin tablets and served as controls. After 4 wk of prednisone in reducing dosage, serum sIL-2R fell significantly from 673.6 ± 52.9 U/ml to 584.8 ± 39.4 U/ml (mean ± SE, p < 0.05). It rose to 733.4 ± 45.7 U/ml (p < 0.05) on the 4th wk of interferon, but returned to pretreatment level at completion of interferon. There was a significant correlation between serum sIL-2R and alanine aminotransferase levels (r = 0.36, p < 0.001). The level of serum sIL-2R before treatment and its response to prednisone and interferon were not useful in predicting seroconversion of hepatitis B e antigen and anti-hepatitis B e.en_HK
dc.languageengen_US
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/ajg/index.htmlen_HK
dc.relation.ispartofAmerican Journal of Gastroenterologyen_HK
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshAlanine Transaminase - Blooden_US
dc.subject.meshChronic Diseaseen_US
dc.subject.meshFemaleen_US
dc.subject.meshHepatitis B - Immunologyen_US
dc.subject.meshHepatitis B Antibodies - Biosynthesisen_US
dc.subject.meshHepatitis B E Antigens - Immunologyen_US
dc.subject.meshHumansen_US
dc.subject.meshInterferon-Alpha - Pharmacologyen_US
dc.subject.meshMaleen_US
dc.subject.meshMultivariate Analysisen_US
dc.subject.meshPrednisone - Pharmacologyen_US
dc.subject.meshReceptors, Interleukin-2 - Drug Effectsen_US
dc.subject.meshRegression Analysisen_US
dc.subject.meshSolubilityen_US
dc.titleEffects of α-interferon and prednisone on serum-soluble interleukin-2 receptor (sIL-2R) in chronic hepatitis B infectionen_HK
dc.typeArticleen_HK
dc.identifier.emailLeung, JCK: jckleung@hku.hken_HK
dc.identifier.emailKar Neng Lai: knlai@hku.hken_HK
dc.identifier.authorityLeung, JCK=rp00448en_HK
dc.identifier.authorityKar Neng Lai=rp00324en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid1728107-
dc.identifier.scopuseid_2-s2.0-0026547604en_HK
dc.identifier.volume87en_HK
dc.identifier.issue1en_HK
dc.identifier.spage113en_HK
dc.identifier.epage117en_HK
dc.identifier.isiWOS:A1992GX88700025-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridLeung, NWY=26643107200en_HK
dc.identifier.scopusauthoridLeung, JCK=7202180349en_HK
dc.identifier.scopusauthoridTam, JS=24788939600en_HK
dc.identifier.scopusauthoridLau, JTF=26643560600en_HK
dc.identifier.scopusauthoridKar Neng Lai=7402135706en_HK

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