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Article: Thyrotrophin-blocking antibodies in congenital hypothyroidism

TitleThyrotrophin-blocking antibodies in congenital hypothyroidism
Authors
KeywordsCongenital hypothyroidism
Transient neonatal hypothyroidism
TSH-blocking antibodies
Issue Date1992
Citation
Journal Of Paediatrics And Child Health, 1992, v. 28 n. 1, p. 50-53 How to Cite?
AbstractThe role of transplacental transfer of maternal thyrotrophin (TSH)-blocking antibodies causing congenital hypothyroidism in Southern Chinese children was examined in this study. Twenty-two mothers of 24 patients with congenital hypothyroidism were studied 3-5 years after delivery. None of them had thyroid dysfunction at delivery or at the time of study. None had antithyroglobulin or antimicrosomal antibody. Only one mother was found to have TSH-binding inhibitory immunoglobulin (TBII), and her child had agenesis of the thyroid. This woman had Graves' disease in remission for 2 years before delivery. None had TSH-stimulated cAMP response inhibitory immunoglobulin (TSII). Ten of the 24 congenital hypothyroid children had transient neonatal hypothyroidism, seven had agenesis of the thyroid, six had dyshormonogenesis and one had a sublingual thyroid. As none of the mothers who had children with transient neonatal hypothyroidism had blocking antibodies at the time of study, the aetiology of the transient neonatal hypothyroidism remains unclear. These data suggest that maternal TSH-blocking antibodies do not play a role in most cases of sporadic congenital hypothyroidism.
Persistent Identifierhttp://hdl.handle.net/10722/161922
ISSN
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorKung, AWCen_HK
dc.contributor.authorLow, LCKen_HK
dc.date.accessioned2012-09-05T05:16:03Z-
dc.date.available2012-09-05T05:16:03Z-
dc.date.issued1992en_HK
dc.identifier.citationJournal Of Paediatrics And Child Health, 1992, v. 28 n. 1, p. 50-53en_HK
dc.identifier.issn0004-993Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/161922-
dc.description.abstractThe role of transplacental transfer of maternal thyrotrophin (TSH)-blocking antibodies causing congenital hypothyroidism in Southern Chinese children was examined in this study. Twenty-two mothers of 24 patients with congenital hypothyroidism were studied 3-5 years after delivery. None of them had thyroid dysfunction at delivery or at the time of study. None had antithyroglobulin or antimicrosomal antibody. Only one mother was found to have TSH-binding inhibitory immunoglobulin (TBII), and her child had agenesis of the thyroid. This woman had Graves' disease in remission for 2 years before delivery. None had TSH-stimulated cAMP response inhibitory immunoglobulin (TSII). Ten of the 24 congenital hypothyroid children had transient neonatal hypothyroidism, seven had agenesis of the thyroid, six had dyshormonogenesis and one had a sublingual thyroid. As none of the mothers who had children with transient neonatal hypothyroidism had blocking antibodies at the time of study, the aetiology of the transient neonatal hypothyroidism remains unclear. These data suggest that maternal TSH-blocking antibodies do not play a role in most cases of sporadic congenital hypothyroidism.en_HK
dc.languageengen_US
dc.relation.ispartofJournal of Paediatrics and Child Healthen_HK
dc.subjectCongenital hypothyroidismen_HK
dc.subjectTransient neonatal hypothyroidismen_HK
dc.subjectTSH-blocking antibodiesen_HK
dc.subject.meshAntibodies - Immunologyen_US
dc.subject.meshAutoantibodies - Immunologyen_US
dc.subject.meshCongenital Hypothyroidismen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshHypothyroidism - Immunologyen_US
dc.subject.meshImmunoglobulins, Thyroid-Stimulatingen_US
dc.subject.meshMaternal-Fetal Exchange - Immunologyen_US
dc.subject.meshPilot Projectsen_US
dc.subject.meshPregnancyen_US
dc.subject.meshRetrospective Studiesen_US
dc.titleThyrotrophin-blocking antibodies in congenital hypothyroidismen_HK
dc.typeArticleen_HK
dc.identifier.emailKung, AWC: awckung@hku.hken_HK
dc.identifier.emailLow, LCK: lcklow@hkucc.hku.hken_HK
dc.identifier.authorityKung, AWC=rp00368en_HK
dc.identifier.authorityLow, LCK=rp00337en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1111/j.1440-1754.1992.tb02617.x-
dc.identifier.pmid1348178-
dc.identifier.scopuseid_2-s2.0-0026526882en_HK
dc.identifier.volume28en_HK
dc.identifier.issue1en_HK
dc.identifier.spage50en_HK
dc.identifier.epage53en_HK
dc.identifier.isiWOS:A1992HE70700010-
dc.identifier.scopusauthoridKung, AWC=7102322339en_HK
dc.identifier.scopusauthoridLow, LCK=7007049461en_HK

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