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Article: T lymphocyte activation in patients with active tuberculosis

TitleT lymphocyte activation in patients with active tuberculosis
Authors
Issue Date1991
PublisherAmerican Thoracic Society. The Journal's web site is located at http://ajrccm.atsjournals.org
Citation
American Review Of Respiratory Disease, 1991, v. 144 n. 2, p. 458-460 How to Cite?
AbstractSoluble interleukin-2 receptor (sIL-2R) is a marker of T lymphocyte activation. We measured the amount of serum sIL-2R in 35 patients with active tuberculosis before the initiation of antituberculous treatment. Twenty had pulmonary parenchymal lesion, 8 had tuberculous pleural effusion, and 7 had tuberculous lymphadenitis. The serum sIL-2R values were markedly elevated in patients with pulmonary tuberculosis (parenchymal lesion and pleural effusion) compared with patients with tuberculous lymphadenitis (2,612 ± 536 versus 538 ± 121 U/ml, p = 0.023), old, inactive tuberculosis (335 ± 23 U/ml, p = 0.001), and normal control subjects (376 ± 38 U/ml, p = 0.001). No significant difference was found between patients with parenchymal lesion and those with tuberculous pleural effusion. There was a positive correlation between serum sIL-2R values and the extent of disease on chest radiograph (r = 0.58, p < 0.001). We conclude that the amount of sIL-2R may be a useful marker of disease activity and extent of involvement in patients with active tuberculous lesions.
Persistent Identifierhttp://hdl.handle.net/10722/161914
ISSN
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorChan, CHSen_HK
dc.contributor.authorLai, KNen_HK
dc.contributor.authorLeung, JCKen_HK
dc.contributor.authorLai, CKWen_HK
dc.date.accessioned2012-09-05T05:16:00Z-
dc.date.available2012-09-05T05:16:00Z-
dc.date.issued1991en_HK
dc.identifier.citationAmerican Review Of Respiratory Disease, 1991, v. 144 n. 2, p. 458-460en_HK
dc.identifier.issn0003-0805en_HK
dc.identifier.urihttp://hdl.handle.net/10722/161914-
dc.description.abstractSoluble interleukin-2 receptor (sIL-2R) is a marker of T lymphocyte activation. We measured the amount of serum sIL-2R in 35 patients with active tuberculosis before the initiation of antituberculous treatment. Twenty had pulmonary parenchymal lesion, 8 had tuberculous pleural effusion, and 7 had tuberculous lymphadenitis. The serum sIL-2R values were markedly elevated in patients with pulmonary tuberculosis (parenchymal lesion and pleural effusion) compared with patients with tuberculous lymphadenitis (2,612 ± 536 versus 538 ± 121 U/ml, p = 0.023), old, inactive tuberculosis (335 ± 23 U/ml, p = 0.001), and normal control subjects (376 ± 38 U/ml, p = 0.001). No significant difference was found between patients with parenchymal lesion and those with tuberculous pleural effusion. There was a positive correlation between serum sIL-2R values and the extent of disease on chest radiograph (r = 0.58, p < 0.001). We conclude that the amount of sIL-2R may be a useful marker of disease activity and extent of involvement in patients with active tuberculous lesions.en_HK
dc.languageengen_US
dc.publisherAmerican Thoracic Society. The Journal's web site is located at http://ajrccm.atsjournals.orgen_HK
dc.relation.ispartofAmerican Review of Respiratory Diseaseen_HK
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshLymphocyte Activation - Immunologyen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshReceptors, Interleukin-2 - Blooden_US
dc.subject.meshT-Lymphocytes - Immunologyen_US
dc.subject.meshTuberculosis, Lymph Node - Immunologyen_US
dc.subject.meshTuberculosis, Pulmonary - Immunologyen_US
dc.titleT lymphocyte activation in patients with active tuberculosisen_HK
dc.typeArticleen_HK
dc.identifier.emailLai, KN: knlai@hku.hken_HK
dc.identifier.emailLeung, JCK: jckleung@hku.hken_HK
dc.identifier.authorityLai, KN=rp00324en_HK
dc.identifier.authorityLeung, JCK=rp00448en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1164/ajrccm/144.2.458-
dc.identifier.pmid1859075-
dc.identifier.scopuseid_2-s2.0-0026399713en_HK
dc.identifier.volume144en_HK
dc.identifier.issue2en_HK
dc.identifier.spage458en_HK
dc.identifier.epage460en_HK
dc.identifier.isiWOS:A1991GA25100037-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridChan, CHS=16169208100en_HK
dc.identifier.scopusauthoridLai, KN=7402135706en_HK
dc.identifier.scopusauthoridLeung, JCK=7202180349en_HK
dc.identifier.scopusauthoridLai, CKW=7403086390en_HK

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