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Article: T-lymphoblastic lymphoma arising in the small intestine

TitleT-lymphoblastic lymphoma arising in the small intestine
Authors
Issue Date1991
Citation
Pathology, 1991, v. 23 n. 4, p. 356-359 How to Cite?
AbstractThe authors report the clinical, pathological and immunological features of a case of T-lymphoblastic lymphoma presenting with protein-losing enteropathy. There was extensive multifocal involvement of the duodenum, jejunum and ileum. The mediastinum was not enlarged; the peripheral blood picture and bilateral bone marrow trephine biopsies were unremarkable. The tumor cells were positive for terminal deoxynucleotide transferase, CD3, CD2, CD7 and CD10; they were negative for CD1, CD5, CD4, CD8 and HLA-DR. The immunophenotype was that of an immature thymic T-cell. Monocytic and B-cell markers were negative. Despite initial dose reduction in chemotherapy, the patient still developed massive intestinal hemorrhage and succumbed 2 wks after treatment. Postmortem examination confirmed absence of thymic involvement. The overall picture strongly suggests a primary intestinal origin of this T-lymphoblastic lymphoma which contradicts the conventional wisdom that T-lymphoblastic lymphoma arises in the thymus from primitive cortical lymphocytes before rapidly disseminating.
Persistent Identifierhttp://hdl.handle.net/10722/161912
ISSN
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorChiu, EKWen_US
dc.contributor.authorLoke, SLen_US
dc.contributor.authorChan, ACLen_US
dc.contributor.authorLiang, RHSen_US
dc.date.accessioned2012-09-05T05:15:59Z-
dc.date.available2012-09-05T05:15:59Z-
dc.date.issued1991en_US
dc.identifier.citationPathology, 1991, v. 23 n. 4, p. 356-359en_US
dc.identifier.issn0031-3205en_US
dc.identifier.urihttp://hdl.handle.net/10722/161912-
dc.description.abstractThe authors report the clinical, pathological and immunological features of a case of T-lymphoblastic lymphoma presenting with protein-losing enteropathy. There was extensive multifocal involvement of the duodenum, jejunum and ileum. The mediastinum was not enlarged; the peripheral blood picture and bilateral bone marrow trephine biopsies were unremarkable. The tumor cells were positive for terminal deoxynucleotide transferase, CD3, CD2, CD7 and CD10; they were negative for CD1, CD5, CD4, CD8 and HLA-DR. The immunophenotype was that of an immature thymic T-cell. Monocytic and B-cell markers were negative. Despite initial dose reduction in chemotherapy, the patient still developed massive intestinal hemorrhage and succumbed 2 wks after treatment. Postmortem examination confirmed absence of thymic involvement. The overall picture strongly suggests a primary intestinal origin of this T-lymphoblastic lymphoma which contradicts the conventional wisdom that T-lymphoblastic lymphoma arises in the thymus from primitive cortical lymphocytes before rapidly disseminating.en_US
dc.languageengen_US
dc.relation.ispartofPathologyen_US
dc.subject.meshAdulten_US
dc.subject.meshAntigens, Cd - Analysisen_US
dc.subject.meshAntigens, Cd2en_US
dc.subject.meshAntigens, Cd3en_US
dc.subject.meshAntigens, Cd7en_US
dc.subject.meshAntigens, Differentiation - Analysisen_US
dc.subject.meshAntigens, Differentiation, T-Lymphocyte - Analysisen_US
dc.subject.meshAntigens, Neoplasm - Analysisen_US
dc.subject.meshDuodenal Neoplasms - Immunology - Pathologyen_US
dc.subject.meshHumansen_US
dc.subject.meshIleal Neoplasms - Immunology - Pathologyen_US
dc.subject.meshImmunophenotypingen_US
dc.subject.meshJejunal Neoplasms - Immunology - Pathologyen_US
dc.subject.meshLymphoma, T-Cell - Immunology - Pathologyen_US
dc.subject.meshMaleen_US
dc.subject.meshNeprilysinen_US
dc.subject.meshPrecursor Cell Lymphoblastic Leukemia-Lymphoma - Immunology - Pathologyen_US
dc.subject.meshReceptors, Antigen, T-Cell - Analysisen_US
dc.subject.meshReceptors, Immunologic - Analysisen_US
dc.titleT-lymphoblastic lymphoma arising in the small intestineen_US
dc.typeArticleen_US
dc.identifier.emailLiang, RHS:rliang@hku.hken_US
dc.identifier.authorityLiang, RHS=rp00345en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.3109/00313029109063605-
dc.identifier.pmid1723795-
dc.identifier.scopuseid_2-s2.0-0026349747en_US
dc.identifier.volume23en_US
dc.identifier.issue4en_US
dc.identifier.spage356en_US
dc.identifier.epage359en_US
dc.identifier.isiWOS:A1991HJ80000018-
dc.identifier.scopusauthoridChiu, EKW=24827833600en_US
dc.identifier.scopusauthoridLoke, SL=7006559512en_US
dc.identifier.scopusauthoridChan, ACL=16047349300en_US
dc.identifier.scopusauthoridLiang, RHS=26643224900en_US

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