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Article: Increased activity of oxygen free radicals during reperfusion in patients with peripheral arterial disease undergoing percutaneous peripheral artery balloon angioplasty

TitleIncreased activity of oxygen free radicals during reperfusion in patients with peripheral arterial disease undergoing percutaneous peripheral artery balloon angioplasty
Authors
Issue Date1991
Citation
International Angiology, 1991, v. 10 n. 4, p. 244-246 How to Cite?
AbstractModern balloon angioplasty plays an important role in the treatment of localised arterial lesions in patients with peripheral vascular disease (PVD). However, the process of angioplasty produces a situation of acute ischaemia followed by reperfusion and animal studies have shown such situation to be associated with an increase in free radical (FR) generation. FRs cause tissue damage and may be prothrombotic and may therefore contribute to the occurrence of restenosis. Release of FRs during reperfusion has not been fully investigated in humans. We studied the FR activity in 44 patients with PVD in the superficial or popliteal arteries receiving angioplasty treatmemt. Thirty patients had stenotic lesions and 14 had totally occlusive disease. Baseline blood samples were taken from the arterial catheter for the assay of malondialdehyde (MDA) (spectrophotometric thiobarbituric acid assay) immediately before and after balloon inflation. MDA is a measure of lipid peroxidation which is an indicator of FR activity. MDA levels during reperfusion were significantly higher than those immediately prior to balloon inflation {8.4 (0.29) vs 8.1 (0.24) μmol/l, respectively: mean increase-0.34 (0.13) μmol/l; [mean (sem)] p < 0.01 (paired Wilcoxon rank test) } in the stenotic lesions. Such changes were not observed in the totally occlusive lesions [7.26 (0.39) vs 7.26 (0.48) μmol/l, respectively; p = 0.75]. Our study has shown increased FR release following angioplasty in patients with stenotic, but not occlusive, peripheral vascular lesions. Angioplasty of the stenotic lesions creats a situation of acute ischaemia and reperfusion whereas that of the occlusive lesions leads to the reperfusion of a chronically ischaemic area. Thus, our study has confirmed previous animal studies of increased FR activity during reperfusion following acute ischaemia. Although the mechanism of this phenomenon is not clearly understood, it may be responsible for the development of restenosis and contribute to tissue damage during treatment with thrombolytic agents. Furthermore, the above situation may be used as a model to assess the effects of antioxidative agents.
Persistent Identifierhttp://hdl.handle.net/10722/161908
ISSN
2015 Impact Factor: 0.899
2015 SCImago Journal Rankings: 0.355
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLau, CSen_US
dc.contributor.authorScott, Nen_US
dc.contributor.authorShaw, JWen_US
dc.contributor.authorBelch, JJFen_US
dc.date.accessioned2012-09-05T05:15:58Z-
dc.date.available2012-09-05T05:15:58Z-
dc.date.issued1991en_US
dc.identifier.citationInternational Angiology, 1991, v. 10 n. 4, p. 244-246en_US
dc.identifier.issn0392-9590en_US
dc.identifier.urihttp://hdl.handle.net/10722/161908-
dc.description.abstractModern balloon angioplasty plays an important role in the treatment of localised arterial lesions in patients with peripheral vascular disease (PVD). However, the process of angioplasty produces a situation of acute ischaemia followed by reperfusion and animal studies have shown such situation to be associated with an increase in free radical (FR) generation. FRs cause tissue damage and may be prothrombotic and may therefore contribute to the occurrence of restenosis. Release of FRs during reperfusion has not been fully investigated in humans. We studied the FR activity in 44 patients with PVD in the superficial or popliteal arteries receiving angioplasty treatmemt. Thirty patients had stenotic lesions and 14 had totally occlusive disease. Baseline blood samples were taken from the arterial catheter for the assay of malondialdehyde (MDA) (spectrophotometric thiobarbituric acid assay) immediately before and after balloon inflation. MDA is a measure of lipid peroxidation which is an indicator of FR activity. MDA levels during reperfusion were significantly higher than those immediately prior to balloon inflation {8.4 (0.29) vs 8.1 (0.24) μmol/l, respectively: mean increase-0.34 (0.13) μmol/l; [mean (sem)] p < 0.01 (paired Wilcoxon rank test) } in the stenotic lesions. Such changes were not observed in the totally occlusive lesions [7.26 (0.39) vs 7.26 (0.48) μmol/l, respectively; p = 0.75]. Our study has shown increased FR release following angioplasty in patients with stenotic, but not occlusive, peripheral vascular lesions. Angioplasty of the stenotic lesions creats a situation of acute ischaemia and reperfusion whereas that of the occlusive lesions leads to the reperfusion of a chronically ischaemic area. Thus, our study has confirmed previous animal studies of increased FR activity during reperfusion following acute ischaemia. Although the mechanism of this phenomenon is not clearly understood, it may be responsible for the development of restenosis and contribute to tissue damage during treatment with thrombolytic agents. Furthermore, the above situation may be used as a model to assess the effects of antioxidative agents.en_US
dc.languageengen_US
dc.relation.ispartofInternational Angiologyen_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshAngioplasty, Balloon - Adverse Effectsen_US
dc.subject.meshFemaleen_US
dc.subject.meshFemoral Arteryen_US
dc.subject.meshFree Radicals - Metabolismen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMalondialdehyde - Metabolismen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshPeripheral Vascular Diseases - Therapyen_US
dc.subject.meshPopliteal Arteryen_US
dc.subject.meshReperfusionen_US
dc.subject.meshThrombosis - Etiologyen_US
dc.titleIncreased activity of oxygen free radicals during reperfusion in patients with peripheral arterial disease undergoing percutaneous peripheral artery balloon angioplastyen_US
dc.typeArticleen_US
dc.identifier.emailLau, CS:cslau@hku.hken_US
dc.identifier.authorityLau, CS=rp01348en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid1839159en_US
dc.identifier.scopuseid_2-s2.0-0026318950en_US
dc.identifier.volume10en_US
dc.identifier.issue4en_US
dc.identifier.spage244en_US
dc.identifier.epage246en_US
dc.identifier.isiWOS:A1991HC02800011-
dc.publisher.placeItalyen_US
dc.identifier.scopusauthoridLau, CS=14035682100en_US
dc.identifier.scopusauthoridScott, N=35451126800en_US
dc.identifier.scopusauthoridShaw, JW=35571899500en_US
dc.identifier.scopusauthoridBelch, JJF=7101752870en_US

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