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Article: Systemic effects of inflammation in bronchiectasis

TitleSystemic effects of inflammation in bronchiectasis
Authors
Issue Date1991
PublisherElsevier Ltd. The Journal's web site is located at http://www.elsevier.com/locate/rmed
Citation
Respiratory Medicine, 1991, v. 85 n. 6, p. 521-525 How to Cite?
AbstractA group of bronchiectatic subjects in the clinically stable state were studied for systemic evidence of inflammation. The following parameters were evaluated: body weight, serum albumin, serum globulin, serum alpha 1 antitrypsin (α 1AT) and peripheral white cell count. For serum albumin and globulin, comparison was made between subjects with bronchiectasis and control subjects with no known pulmonary disease matched for sex and age, and for serum α 1AT and peripheral white cell count, matched for smoking habit as well. The bronchiectatic subjects showed systemic effects of inflammation as indicated by lower body weight and serum albumin (P<0.01), higher serum globulin (P<0.001), serum α 1AT (P<0.05) and total leucocyte count (P<0.05). Differential white cell count showed that the elevation was distributed in most cell types. Correlation matrix was done for the above systemic parameters and indices of airway inflammation including sputum volume, purulence, and polymorph count and FEV 1. There was an inverse correlation between total peripheral WBC count and FEV 1 in percentage of predicted (P<0.01), and a positive correlation between sputum purulence and sputum polymorph score (P<0.05). This suggests that host peripheral leucocyte response may be a factor in the determination of lung function.
Persistent Identifierhttp://hdl.handle.net/10722/161897
ISSN
2015 Impact Factor: 3.036
2015 SCImago Journal Rankings: 1.396
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorIp, Men_US
dc.contributor.authorLam, WKen_US
dc.contributor.authorChan, JCen_US
dc.contributor.authorLiong, Een_US
dc.date.accessioned2012-09-05T05:15:53Z-
dc.date.available2012-09-05T05:15:53Z-
dc.date.issued1991en_US
dc.identifier.citationRespiratory Medicine, 1991, v. 85 n. 6, p. 521-525en_US
dc.identifier.issn0954-6111en_US
dc.identifier.urihttp://hdl.handle.net/10722/161897-
dc.description.abstractA group of bronchiectatic subjects in the clinically stable state were studied for systemic evidence of inflammation. The following parameters were evaluated: body weight, serum albumin, serum globulin, serum alpha 1 antitrypsin (α 1AT) and peripheral white cell count. For serum albumin and globulin, comparison was made between subjects with bronchiectasis and control subjects with no known pulmonary disease matched for sex and age, and for serum α 1AT and peripheral white cell count, matched for smoking habit as well. The bronchiectatic subjects showed systemic effects of inflammation as indicated by lower body weight and serum albumin (P<0.01), higher serum globulin (P<0.001), serum α 1AT (P<0.05) and total leucocyte count (P<0.05). Differential white cell count showed that the elevation was distributed in most cell types. Correlation matrix was done for the above systemic parameters and indices of airway inflammation including sputum volume, purulence, and polymorph count and FEV 1. There was an inverse correlation between total peripheral WBC count and FEV 1 in percentage of predicted (P<0.01), and a positive correlation between sputum purulence and sputum polymorph score (P<0.05). This suggests that host peripheral leucocyte response may be a factor in the determination of lung function.en_US
dc.languageengen_US
dc.publisherElsevier Ltd. The Journal's web site is located at http://www.elsevier.com/locate/rmeden_US
dc.relation.ispartofRespiratory Medicineen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshBronchiectasis - Blood - Physiopathologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshForced Expiratory Volume - Physiologyen_US
dc.subject.meshHumansen_US
dc.subject.meshImmunoglobulins - Analysisen_US
dc.subject.meshInflammation - Blooden_US
dc.subject.meshLeukocyte Counten_US
dc.subject.meshLung - Physiopathologyen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshSerum Albumin - Analysisen_US
dc.subject.meshSerum Globulins - Analysisen_US
dc.subject.meshAlpha 1-Antitrypsin - Analysisen_US
dc.titleSystemic effects of inflammation in bronchiectasisen_US
dc.typeArticleen_US
dc.identifier.emailIp, M:msmip@hku.hken_US
dc.identifier.authorityIp, M=rp00347en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/S0954-6111(06)80271-4-
dc.identifier.pmid1775679-
dc.identifier.scopuseid_2-s2.0-0026047442en_US
dc.identifier.volume85en_US
dc.identifier.issue6en_US
dc.identifier.spage521en_US
dc.identifier.epage525en_US
dc.identifier.isiWOS:A1991GQ02900013-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridIp, M=7102423259en_US
dc.identifier.scopusauthoridLam, WK=7203021937en_US
dc.identifier.scopusauthoridChan, JC=23090202000en_US
dc.identifier.scopusauthoridLiong, E=35938810100en_US

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