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Article: 1,25-Dihydroxycholecalciferol and peritoneal macrophage chemotaxis in patients on continuous ambulatory peritoneal dialysis
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Title1,25-Dihydroxycholecalciferol and peritoneal macrophage chemotaxis in patients on continuous ambulatory peritoneal dialysis
 
AuthorsChan, PCK1
Ip, MSM1
Pun, KK1
 
Issue Date1991
 
PublisherS Karger AG. The Journal's web site is located at http://www.karger.com/NEF
 
CitationNephron, 1991, v. 59 n. 3, p. 434-439 [How to Cite?]
DOI: http://dx.doi.org/10.1159/000186604
 
AbstractSingle graded doses of 1,25-dihydroxycholecalciferol of 2 and 4 μg were added intraperitoneally into the overnight 1.5% glucose dialysate of 6 patients on continuous ambulatory peritoneal dialysis. The effect on peritoneal macrophage chemotaxis and random migration was studied and compared with the baseline when no 1,25-(OH)2D3 was added. No consistent effect on peritoneal macrophage chemotaxis was observed. Random migration was significantly depressed at 4 μg when compared with baseline (5.4 ± 1.9 vs. 12.2 ± 3.7 cells/high-power field, p < 0.05). The potential clinical role of 1,25-(OH)2D3 as an immune modulator requires further study.
 
ISSN0028-2766
 
DOIhttp://dx.doi.org/10.1159/000186604
 
ISI Accession Number IDWOS:A1991GK33600014
 
DC FieldValue
dc.contributor.authorChan, PCK
 
dc.contributor.authorIp, MSM
 
dc.contributor.authorPun, KK
 
dc.date.accessioned2012-09-05T05:15:48Z
 
dc.date.available2012-09-05T05:15:48Z
 
dc.date.issued1991
 
dc.description.abstractSingle graded doses of 1,25-dihydroxycholecalciferol of 2 and 4 μg were added intraperitoneally into the overnight 1.5% glucose dialysate of 6 patients on continuous ambulatory peritoneal dialysis. The effect on peritoneal macrophage chemotaxis and random migration was studied and compared with the baseline when no 1,25-(OH)2D3 was added. No consistent effect on peritoneal macrophage chemotaxis was observed. Random migration was significantly depressed at 4 μg when compared with baseline (5.4 ± 1.9 vs. 12.2 ± 3.7 cells/high-power field, p < 0.05). The potential clinical role of 1,25-(OH)2D3 as an immune modulator requires further study.
 
dc.description.naturelink_to_subscribed_fulltext
 
dc.identifier.citationNephron, 1991, v. 59 n. 3, p. 434-439 [How to Cite?]
DOI: http://dx.doi.org/10.1159/000186604
 
dc.identifier.doihttp://dx.doi.org/10.1159/000186604
 
dc.identifier.epage439
 
dc.identifier.isiWOS:A1991GK33600014
 
dc.identifier.issn0028-2766
 
dc.identifier.issue3
 
dc.identifier.pmid1758534
 
dc.identifier.scopuseid_2-s2.0-0025951248
 
dc.identifier.spage434
 
dc.identifier.urihttp://hdl.handle.net/10722/161884
 
dc.identifier.volume59
 
dc.languageeng
 
dc.publisherS Karger AG. The Journal's web site is located at http://www.karger.com/NEF
 
dc.publisher.placeSwitzerland
 
dc.relation.ispartofNephron
 
dc.subject.meshAdult
 
dc.subject.meshCalcitriol - Administration & Dosage - Blood - Pharmacology
 
dc.subject.meshCell Movement - Drug Effects
 
dc.subject.meshChemotaxis - Drug Effects
 
dc.subject.meshFemale
 
dc.subject.meshHumans
 
dc.subject.meshInjections, Intraperitoneal
 
dc.subject.meshKidney Failure, Chronic - Drug Therapy - Physiopathology - Therapy
 
dc.subject.meshMacrophages - Drug Effects - Physiology
 
dc.subject.meshMale
 
dc.subject.meshMiddle Aged
 
dc.subject.meshPeritoneal Dialysis, Continuous Ambulatory
 
dc.title1,25-Dihydroxycholecalciferol and peritoneal macrophage chemotaxis in patients on continuous ambulatory peritoneal dialysis
 
dc.typeArticle
 
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<item><contributor.author>Chan, PCK</contributor.author>
<contributor.author>Ip, MSM</contributor.author>
<contributor.author>Pun, KK</contributor.author>
<date.accessioned>2012-09-05T05:15:48Z</date.accessioned>
<date.available>2012-09-05T05:15:48Z</date.available>
<date.issued>1991</date.issued>
<identifier.citation>Nephron, 1991, v. 59 n. 3, p. 434-439</identifier.citation>
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<description.abstract>Single graded doses of 1,25-dihydroxycholecalciferol of 2 and 4 &#956;g were added intraperitoneally into the overnight 1.5% glucose dialysate of 6 patients on continuous ambulatory peritoneal dialysis. The effect on peritoneal macrophage chemotaxis and random migration was studied and compared with the baseline when no 1,25-(OH)2D3 was added. No consistent effect on peritoneal macrophage chemotaxis was observed. Random migration was significantly depressed at 4 &#956;g when compared with baseline (5.4 &#177; 1.9 vs. 12.2 &#177; 3.7 cells/high-power field, p &lt; 0.05). The potential clinical role of 1,25-(OH)2D3 as an immune modulator requires further study.</description.abstract>
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<subject.mesh>Adult</subject.mesh>
<subject.mesh>Calcitriol - Administration &amp; Dosage - Blood - Pharmacology</subject.mesh>
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<subject.mesh>Chemotaxis - Drug Effects</subject.mesh>
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<subject.mesh>Humans</subject.mesh>
<subject.mesh>Injections, Intraperitoneal</subject.mesh>
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<subject.mesh>Macrophages - Drug Effects - Physiology</subject.mesh>
<subject.mesh>Male</subject.mesh>
<subject.mesh>Middle Aged</subject.mesh>
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Author Affiliations
  1. The University of Hong Kong