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Article: 1,25-Dihydroxycholecalciferol and peritoneal macrophage chemotaxis in patients on continuous ambulatory peritoneal dialysis

Title1,25-Dihydroxycholecalciferol and peritoneal macrophage chemotaxis in patients on continuous ambulatory peritoneal dialysis
Authors
Issue Date1991
PublisherS Karger AG. The Journal's web site is located at http://www.karger.com/NEF
Citation
Nephron, 1991, v. 59 n. 3, p. 434-439 How to Cite?
AbstractSingle graded doses of 1,25-dihydroxycholecalciferol of 2 and 4 μg were added intraperitoneally into the overnight 1.5% glucose dialysate of 6 patients on continuous ambulatory peritoneal dialysis. The effect on peritoneal macrophage chemotaxis and random migration was studied and compared with the baseline when no 1,25-(OH)2D3 was added. No consistent effect on peritoneal macrophage chemotaxis was observed. Random migration was significantly depressed at 4 μg when compared with baseline (5.4 ± 1.9 vs. 12.2 ± 3.7 cells/high-power field, p < 0.05). The potential clinical role of 1,25-(OH)2D3 as an immune modulator requires further study.
Persistent Identifierhttp://hdl.handle.net/10722/161884
ISSN
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorChan, PCKen_US
dc.contributor.authorIp, MSMen_US
dc.contributor.authorPun, KKen_US
dc.date.accessioned2012-09-05T05:15:48Z-
dc.date.available2012-09-05T05:15:48Z-
dc.date.issued1991en_US
dc.identifier.citationNephron, 1991, v. 59 n. 3, p. 434-439en_US
dc.identifier.issn0028-2766en_US
dc.identifier.urihttp://hdl.handle.net/10722/161884-
dc.description.abstractSingle graded doses of 1,25-dihydroxycholecalciferol of 2 and 4 μg were added intraperitoneally into the overnight 1.5% glucose dialysate of 6 patients on continuous ambulatory peritoneal dialysis. The effect on peritoneal macrophage chemotaxis and random migration was studied and compared with the baseline when no 1,25-(OH)2D3 was added. No consistent effect on peritoneal macrophage chemotaxis was observed. Random migration was significantly depressed at 4 μg when compared with baseline (5.4 ± 1.9 vs. 12.2 ± 3.7 cells/high-power field, p < 0.05). The potential clinical role of 1,25-(OH)2D3 as an immune modulator requires further study.en_US
dc.languageengen_US
dc.publisherS Karger AG. The Journal's web site is located at http://www.karger.com/NEFen_US
dc.relation.ispartofNephronen_US
dc.subject.meshAdulten_US
dc.subject.meshCalcitriol - Administration & Dosage - Blood - Pharmacologyen_US
dc.subject.meshCell Movement - Drug Effectsen_US
dc.subject.meshChemotaxis - Drug Effectsen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshInjections, Intraperitonealen_US
dc.subject.meshKidney Failure, Chronic - Drug Therapy - Physiopathology - Therapyen_US
dc.subject.meshMacrophages - Drug Effects - Physiologyen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshPeritoneal Dialysis, Continuous Ambulatoryen_US
dc.title1,25-Dihydroxycholecalciferol and peritoneal macrophage chemotaxis in patients on continuous ambulatory peritoneal dialysisen_US
dc.typeArticleen_US
dc.identifier.emailIp, MSM:msmip@hku.hken_US
dc.identifier.authorityIp, MSM=rp00347en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1159/000186604-
dc.identifier.pmid1758534en_US
dc.identifier.scopuseid_2-s2.0-0025951248en_US
dc.identifier.volume59en_US
dc.identifier.issue3en_US
dc.identifier.spage434en_US
dc.identifier.epage439en_US
dc.identifier.isiWOS:A1991GK33600014-
dc.publisher.placeSwitzerlanden_US
dc.identifier.scopusauthoridChan, PCK=7403497841en_US
dc.identifier.scopusauthoridIp, MSM=7102423259en_US
dc.identifier.scopusauthoridPun, KK=7006538877en_US

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