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Article: Cytokine production by peripheral blood mononuclear cells in IgA nephropathy

TitleCytokine production by peripheral blood mononuclear cells in IgA nephropathy
Authors
Keywordscytokine receptor expression
IgA nephropathy
interferon-gamma
interleukins
peripheral blood mononuclear cells
Issue Date1991
PublisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/CEI
Citation
Clinical And Experimental Immunology, 1991, v. 85 n. 2, p. 240-245 How to Cite?
AbstractThe regulation of cytokine production and T cell proliferation by other cytokines is mandatory in mediating inflammatory responses but the full understanding is far from complete. We have previously reported increased production of IL-2 and IL-2 receptors (IL-2R) in IgA nephropathy. The present study was undertaken to examine other cytokine production during T cell activation in IgA nephropathy. Peripheral blood mononuclear cells (PBMC) from 17 IgA nephritic patients and 14 controls were cultured with phytohaemagglutinin and phorbol myristate acetate for 48 h for maximal cytokine production. IL-2Rs and IL-4 receptors (IL-4Rs) expressed on cultured PBMC were studied by a radioimmunoassay using monoclonal antibodies against these receptors. Although the total cellular IL-2R expression and percentages of T helper and T suppressor cells did not differ between the patients and controls, there was a significant increase in activated T helper cells expressing IL-2R in patients with IgA nephropathy. The total cellular IL-4R expression was elevated in IgA nephritic patients (P < 0.005). IL-2 production by PBMC was raised in IgA nephritic patients compared with controls (P < 0.05) but no difference in IL-4 or IL-6 production was observed. The interferon-gamma production by PBMG was significantly increased in patients with IgA nephropathy (P < 0.025). No correlation was observed between individual cytokine levels. Our data suggest there are selective increases in cytokine production in IgA nephropathy.
Persistent Identifierhttp://hdl.handle.net/10722/161866
ISSN
2015 Impact Factor: 3.148
2015 SCImago Journal Rankings: 1.369
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLai, KNen_HK
dc.contributor.authorLeung, JCKen_HK
dc.contributor.authorLi, PKTen_HK
dc.contributor.authorLui, SFen_HK
dc.date.accessioned2012-09-05T05:15:38Z-
dc.date.available2012-09-05T05:15:38Z-
dc.date.issued1991en_HK
dc.identifier.citationClinical And Experimental Immunology, 1991, v. 85 n. 2, p. 240-245en_HK
dc.identifier.issn0009-9104en_HK
dc.identifier.urihttp://hdl.handle.net/10722/161866-
dc.description.abstractThe regulation of cytokine production and T cell proliferation by other cytokines is mandatory in mediating inflammatory responses but the full understanding is far from complete. We have previously reported increased production of IL-2 and IL-2 receptors (IL-2R) in IgA nephropathy. The present study was undertaken to examine other cytokine production during T cell activation in IgA nephropathy. Peripheral blood mononuclear cells (PBMC) from 17 IgA nephritic patients and 14 controls were cultured with phytohaemagglutinin and phorbol myristate acetate for 48 h for maximal cytokine production. IL-2Rs and IL-4 receptors (IL-4Rs) expressed on cultured PBMC were studied by a radioimmunoassay using monoclonal antibodies against these receptors. Although the total cellular IL-2R expression and percentages of T helper and T suppressor cells did not differ between the patients and controls, there was a significant increase in activated T helper cells expressing IL-2R in patients with IgA nephropathy. The total cellular IL-4R expression was elevated in IgA nephritic patients (P < 0.005). IL-2 production by PBMC was raised in IgA nephritic patients compared with controls (P < 0.05) but no difference in IL-4 or IL-6 production was observed. The interferon-gamma production by PBMG was significantly increased in patients with IgA nephropathy (P < 0.025). No correlation was observed between individual cytokine levels. Our data suggest there are selective increases in cytokine production in IgA nephropathy.en_HK
dc.languageengen_US
dc.publisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/CEIen_HK
dc.relation.ispartofClinical and Experimental Immunologyen_HK
dc.subjectcytokine receptor expressionen_HK
dc.subjectIgA nephropathyen_HK
dc.subjectinterferon-gammaen_HK
dc.subjectinterleukinsen_HK
dc.subjectperipheral blood mononuclear cellsen_HK
dc.subject.meshCytokines - Biosynthesisen_US
dc.subject.meshGlomerulonephritis, Iga - Immunologyen_US
dc.subject.meshHumansen_US
dc.subject.meshInterferon-Gamma - Biosynthesisen_US
dc.subject.meshInterleukin-2 - Biosynthesisen_US
dc.subject.meshLeukocytes, Mononuclear - Immunology - Metabolismen_US
dc.subject.meshLymphocyte Activationen_US
dc.subject.meshReceptors, Interleukin-2 - Biosynthesisen_US
dc.subject.meshReceptors, Interleukin-4en_US
dc.subject.meshReceptors, Mitogen - Biosynthesisen_US
dc.titleCytokine production by peripheral blood mononuclear cells in IgA nephropathyen_HK
dc.typeArticleen_HK
dc.identifier.emailLai, KN: knlai@hku.hken_HK
dc.identifier.emailLeung, JCK: jckleung@hku.hken_HK
dc.identifier.authorityLai, KN=rp00324en_HK
dc.identifier.authorityLeung, JCK=rp00448en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid1907530-
dc.identifier.scopuseid_2-s2.0-0025785267en_HK
dc.identifier.volume85en_HK
dc.identifier.issue2en_HK
dc.identifier.spage240en_HK
dc.identifier.epage245en_HK
dc.identifier.isiWOS:A1991FY64200011-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridLai, KN=7402135706en_HK
dc.identifier.scopusauthoridLeung, JCK=7202180349en_HK
dc.identifier.scopusauthoridLi, PKT=25928016800en_HK
dc.identifier.scopusauthoridLui, SF=55066056500en_HK

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