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Article: Soluble interleukin-2 receptors in patients with nasopharyngeal carcinoma

TitleSoluble interleukin-2 receptors in patients with nasopharyngeal carcinoma
Authors
Issue Date1991
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/28741
Citation
Cancer, 1991, v. 67 n. 8, p. 2180-2185 How to Cite?
AbstractThe authors performed a retrospective analysis of serum soluble interleukin-2 receptor (sIL-2R) levels in 72 patients with nasopharyngeal carcinoma (NPC) using an enzyme immunoassay. Their objectives were to determine the value of serum sIL-2R in estimating the tumor burden, and its predictive value in response to therapy and prognosis. The data showed that serum sIL-2R levels in patients were significantly higher than that of healthy controls. The serum levels correlated with clinical staging and hence the tumor burden of NPC. Serial measurement of serum sIL-2R provided an accurate prognostic index of the clinical response to radiotherapy in at least 89% of patients with raised serum sIL-2R at initial diagnosis (defined as mean + 2 SD of healthy controls) and a reliable predictive index in all patients who subsequently developed distant metastasis despite initial radiotherapy. Simultaneous measurement of Epstein-Barr virus-related serology (IgA-VCA and IgG-EA) failed to demonstrate predictive value comparable with that of serum sIL-2R. The authors conclude that monitoring serum sIL-2R levels has clinical and prognostic significance in patients with NPC and that prospective studies are indicated.
Persistent Identifierhttp://hdl.handle.net/10722/161865
ISSN
2015 Impact Factor: 5.649
2015 SCImago Journal Rankings: 3.188
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorKar Neng Laien_HK
dc.contributor.authorHo, Sen_HK
dc.contributor.authorLeung, JCKen_HK
dc.contributor.authorShiu Ying Tsaoen_HK
dc.date.accessioned2012-09-05T05:15:38Z-
dc.date.available2012-09-05T05:15:38Z-
dc.date.issued1991en_HK
dc.identifier.citationCancer, 1991, v. 67 n. 8, p. 2180-2185en_HK
dc.identifier.issn0008-543Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/161865-
dc.description.abstractThe authors performed a retrospective analysis of serum soluble interleukin-2 receptor (sIL-2R) levels in 72 patients with nasopharyngeal carcinoma (NPC) using an enzyme immunoassay. Their objectives were to determine the value of serum sIL-2R in estimating the tumor burden, and its predictive value in response to therapy and prognosis. The data showed that serum sIL-2R levels in patients were significantly higher than that of healthy controls. The serum levels correlated with clinical staging and hence the tumor burden of NPC. Serial measurement of serum sIL-2R provided an accurate prognostic index of the clinical response to radiotherapy in at least 89% of patients with raised serum sIL-2R at initial diagnosis (defined as mean + 2 SD of healthy controls) and a reliable predictive index in all patients who subsequently developed distant metastasis despite initial radiotherapy. Simultaneous measurement of Epstein-Barr virus-related serology (IgA-VCA and IgG-EA) failed to demonstrate predictive value comparable with that of serum sIL-2R. The authors conclude that monitoring serum sIL-2R levels has clinical and prognostic significance in patients with NPC and that prospective studies are indicated.en_HK
dc.languageengen_US
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/28741en_HK
dc.relation.ispartofCanceren_HK
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshCarcinoma - Blood - Pathology - Radiotherapy - Secondaryen_US
dc.subject.meshEnzyme-Linked Immunosorbent Assayen_US
dc.subject.meshFemaleen_US
dc.subject.meshHerpesvirus 4, Human - Immunologyen_US
dc.subject.meshHumansen_US
dc.subject.meshImmunoglobulin A - Analysisen_US
dc.subject.meshImmunoglobulin G - Analysisen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshMonitoring, Physiologicen_US
dc.subject.meshNasopharyngeal Neoplasms - Blood - Pathology - Radiotherapyen_US
dc.subject.meshNeoplasm Stagingen_US
dc.subject.meshPredictive Value Of Testsen_US
dc.subject.meshReceptors, Interleukin-2 - Blooden_US
dc.subject.meshRetrospective Studiesen_US
dc.titleSoluble interleukin-2 receptors in patients with nasopharyngeal carcinomaen_HK
dc.typeArticleen_HK
dc.identifier.emailKar Neng Lai: knlai@hku.hken_HK
dc.identifier.emailLeung, JCK: jckleung@hku.hken_HK
dc.identifier.authorityKar Neng Lai=rp00324en_HK
dc.identifier.authorityLeung, JCK=rp00448en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1002/1097-0142(19910415)67:8<2180::AID-CNCR2820670829>3.0.CO;2-T-
dc.identifier.pmid1848475-
dc.identifier.scopuseid_2-s2.0-0025779931en_HK
dc.identifier.volume67en_HK
dc.identifier.issue8en_HK
dc.identifier.spage2180en_HK
dc.identifier.epage2185en_HK
dc.identifier.isiWOS:A1991FE03200028-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridKar Neng Lai=7402135706en_HK
dc.identifier.scopusauthoridHo, S=8599112900en_HK
dc.identifier.scopusauthoridLeung, JCK=7202180349en_HK
dc.identifier.scopusauthoridShiu Ying Tsao=7409944435en_HK

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