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Article: Analysis of factors associated with bronchial hyperreactivity to methacholine in bronchiectasis

TitleAnalysis of factors associated with bronchial hyperreactivity to methacholine in bronchiectasis
Authors
Issue Date1991
PublisherSpringer New York LLC. The Journal's web site is located at http://link.springer.de/link/service/journals/00408/
Citation
Lung, 1991, v. 169 n. 1, p. 43-51 How to Cite?
AbstractNonspecific bronchial hyperreactivity (BHR) has been reported to occur in patients with bronchiectasis. To evaluate this further, we studied 77 patients with stable bronchiectasis (noncystic fibrosis) with special reference to the prevalence of BHR to methacholine (MCh), and its relation to lung function, sputum characteristics, concommitant asthma, and atopy. The concentration of MCh required to produce a fall of 20% in forced expiratory volume in 1 s (FEV 1), PC 20, was determined by Wright's nebulization tidal breathing method. BHR defined by a PC 20 ≤ 8 mg/ml was found in 21 of 47 (45%) subjects who underwent bronchial challenge. Presence of BHR was positively associated with low baseline spirometric values, diagnosis of asthma, long duration of disease, and elevated total IgE on univariant analysis, and was significantly related to FEV 1/forced vital capacity (FVC) ratio and asthma on multiple regression analysis. Ten of the 21 hyperreactive subjects did not have clinical asthma, whereas all 11 of 22 subjects with clinical asthma who underwent bronchial challenge were hyperreactive. Among those with BHR, there was a positive correlation between PC 20 and baseline FEV 1. When patients were further classified into asthmatic and nonasthmatic subjects, a positive correlation between PC 20 and FEV 1 was seen only in those without asthma. Frequency of infective episodes and inflammatory score of sputum assessed by average daily volume, purulence, and leukocyte count did not differ significantly in the groups with and without BHR. These results suggest that BHR in patients with bronchiectasis is associated with coexistent asthma and worse spirometric values, and not with the severity of bronchial sepsis.
Persistent Identifierhttp://hdl.handle.net/10722/161861
ISSN
2015 Impact Factor: 2.0
2015 SCImago Journal Rankings: 0.785
ISI Accession Number ID
Errata

 

DC FieldValueLanguage
dc.contributor.authorIp, Men_US
dc.contributor.authorLam, WKen_US
dc.contributor.authorSo, SYen_US
dc.contributor.authorLiong, Een_US
dc.contributor.authorChan, CYen_US
dc.contributor.authorTse, KMen_US
dc.date.accessioned2012-09-05T05:15:34Z-
dc.date.available2012-09-05T05:15:34Z-
dc.date.issued1991en_US
dc.identifier.citationLung, 1991, v. 169 n. 1, p. 43-51en_US
dc.identifier.issn0341-2040en_US
dc.identifier.urihttp://hdl.handle.net/10722/161861-
dc.description.abstractNonspecific bronchial hyperreactivity (BHR) has been reported to occur in patients with bronchiectasis. To evaluate this further, we studied 77 patients with stable bronchiectasis (noncystic fibrosis) with special reference to the prevalence of BHR to methacholine (MCh), and its relation to lung function, sputum characteristics, concommitant asthma, and atopy. The concentration of MCh required to produce a fall of 20% in forced expiratory volume in 1 s (FEV 1), PC 20, was determined by Wright's nebulization tidal breathing method. BHR defined by a PC 20 ≤ 8 mg/ml was found in 21 of 47 (45%) subjects who underwent bronchial challenge. Presence of BHR was positively associated with low baseline spirometric values, diagnosis of asthma, long duration of disease, and elevated total IgE on univariant analysis, and was significantly related to FEV 1/forced vital capacity (FVC) ratio and asthma on multiple regression analysis. Ten of the 21 hyperreactive subjects did not have clinical asthma, whereas all 11 of 22 subjects with clinical asthma who underwent bronchial challenge were hyperreactive. Among those with BHR, there was a positive correlation between PC 20 and baseline FEV 1. When patients were further classified into asthmatic and nonasthmatic subjects, a positive correlation between PC 20 and FEV 1 was seen only in those without asthma. Frequency of infective episodes and inflammatory score of sputum assessed by average daily volume, purulence, and leukocyte count did not differ significantly in the groups with and without BHR. These results suggest that BHR in patients with bronchiectasis is associated with coexistent asthma and worse spirometric values, and not with the severity of bronchial sepsis.en_US
dc.languageengen_US
dc.publisherSpringer New York LLC. The Journal's web site is located at http://link.springer.de/link/service/journals/00408/en_US
dc.relation.ispartofLungen_US
dc.subject.meshAdulten_US
dc.subject.meshAsthma - Complications - Diagnosisen_US
dc.subject.meshBronchial Provocation Testsen_US
dc.subject.meshBronchiectasis - Complications - Physiopathologyen_US
dc.subject.meshBronchoconstriction - Drug Effectsen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMethacholine Chloride - Diagnostic Useen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshSpirometryen_US
dc.subject.meshSputumen_US
dc.titleAnalysis of factors associated with bronchial hyperreactivity to methacholine in bronchiectasisen_US
dc.typeArticleen_US
dc.identifier.emailIp, M:msmip@hku.hken_US
dc.identifier.authorityIp, M=rp00347en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1007/BF02714140-
dc.identifier.pmid2011043-
dc.identifier.scopuseid_2-s2.0-0025763360en_US
dc.identifier.volume169en_US
dc.identifier.issue1en_US
dc.identifier.spage43en_US
dc.identifier.epage51en_US
dc.identifier.isiWOS:A1991ET97400004-
dc.publisher.placeUnited Statesen_US
dc.relation.erratumdoi:10.1007/BF02714159-
dc.relation.erratumeid:eid_2-s2.0-51649147740-
dc.relation.erratumeid:eid_2-s2.0-0025766470-
dc.identifier.scopusauthoridIp, M=7102423259en_US
dc.identifier.scopusauthoridLam, WK=7203021937en_US
dc.identifier.scopusauthoridSo, SY=7102397816en_US
dc.identifier.scopusauthoridLiong, E=35938810100en_US
dc.identifier.scopusauthoridChan, CY=24517697500en_US
dc.identifier.scopusauthoridTse, KM=24789459900en_US

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