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Article: Vasoactive hormones in uremic patients on continuous ambulatory peritoneal dialysis

TitleVasoactive hormones in uremic patients on continuous ambulatory peritoneal dialysis
Authors
KeywordsAtrial natriuretic peptide
Chronic renal failure
Continuous ambulatory peritoneal dialysis
Endothelin
Renin activity
Uremic cardiomyopathy
Issue Date1991
PublisherDustri-Verlag Dr. Karl Feistle. The Journal's web site is located at http://www.clinnephrol.com
Citation
Clinical Nephrology, 1991, v. 35 n. 5, p. 218-223 How to Cite?
AbstractPlasma levels of atrial natriuretic peptide (ANP), renin activity (PRA), and endothelin (ET) are often elevated in uremic patients on hemodialysis treatment. The profile of these vasoactive hormones and their relationships with hemodynamic indices in patients on continuous ambulatory peritoneal dialysis (CAPD), however, are not clear. We therefore measured plasma concentrations of ANP, PRA, ET, together with parathyroid hormone (PTH) in 17 patients (mean age 38.5 years) on maintenance CAPD over a period of 12 weeks. Baseline ANP, PRA, and ET levels were significantly higher than those of healthy subjects, and no significant changes in these indices were observed over the 12 week period. There was a significant positive correlation between levels of plasma ANP and PRA [rank correlation coefficient, R(s) = 0.496, p < 0.05] as has been reported in cardiac failure. Despite the absence of clinically overt heart failure, a significant proportion (approximately 50%) of our patients demonstrated evidence of myocardial dysfunction on echocardiography. Furthermore, a significant positive correlation was demonstrated between plasma ANP and left atrial size [R(s) = 0.61, p < 0.01] and an inverse correlation existed between plasma ANP and the left ventricular ejection fraction [R(s) = 0.51, p < 0.05]. Twelve patients (71%) had biochemical evidence of hyperparathyroidism with raised levels of serum PTH. Our study demonstrates increased levels of plasma ANP, PRA, and ET in uremic patients on long-term CAPD. A positive correlation exists between plasma ANP and PRA suggesting their myocardial function may be compromized and this was confirmed on echocardiography. The possibility that high circulating PTH concentrations contribute to impaired cardiac function in such patients, deserves further study.
Persistent Identifierhttp://hdl.handle.net/10722/161854
ISSN
2015 Impact Factor: 1.065
2015 SCImago Journal Rankings: 0.498
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLai, KNen_HK
dc.contributor.authorLi, PKTen_HK
dc.contributor.authorWoo, KSen_HK
dc.contributor.authorLui, SFen_HK
dc.contributor.authorLeung, JCKen_HK
dc.contributor.authorLaw, Een_HK
dc.contributor.authorNicholls, MGen_HK
dc.date.accessioned2012-09-05T05:15:31Z-
dc.date.available2012-09-05T05:15:31Z-
dc.date.issued1991en_HK
dc.identifier.citationClinical Nephrology, 1991, v. 35 n. 5, p. 218-223en_HK
dc.identifier.issn0301-0430en_HK
dc.identifier.urihttp://hdl.handle.net/10722/161854-
dc.description.abstractPlasma levels of atrial natriuretic peptide (ANP), renin activity (PRA), and endothelin (ET) are often elevated in uremic patients on hemodialysis treatment. The profile of these vasoactive hormones and their relationships with hemodynamic indices in patients on continuous ambulatory peritoneal dialysis (CAPD), however, are not clear. We therefore measured plasma concentrations of ANP, PRA, ET, together with parathyroid hormone (PTH) in 17 patients (mean age 38.5 years) on maintenance CAPD over a period of 12 weeks. Baseline ANP, PRA, and ET levels were significantly higher than those of healthy subjects, and no significant changes in these indices were observed over the 12 week period. There was a significant positive correlation between levels of plasma ANP and PRA [rank correlation coefficient, R(s) = 0.496, p < 0.05] as has been reported in cardiac failure. Despite the absence of clinically overt heart failure, a significant proportion (approximately 50%) of our patients demonstrated evidence of myocardial dysfunction on echocardiography. Furthermore, a significant positive correlation was demonstrated between plasma ANP and left atrial size [R(s) = 0.61, p < 0.01] and an inverse correlation existed between plasma ANP and the left ventricular ejection fraction [R(s) = 0.51, p < 0.05]. Twelve patients (71%) had biochemical evidence of hyperparathyroidism with raised levels of serum PTH. Our study demonstrates increased levels of plasma ANP, PRA, and ET in uremic patients on long-term CAPD. A positive correlation exists between plasma ANP and PRA suggesting their myocardial function may be compromized and this was confirmed on echocardiography. The possibility that high circulating PTH concentrations contribute to impaired cardiac function in such patients, deserves further study.en_HK
dc.languageengen_US
dc.publisherDustri-Verlag Dr. Karl Feistle. The Journal's web site is located at http://www.clinnephrol.comen_HK
dc.relation.ispartofClinical Nephrologyen_HK
dc.subjectAtrial natriuretic peptideen_HK
dc.subjectChronic renal failureen_HK
dc.subjectContinuous ambulatory peritoneal dialysisen_HK
dc.subjectEndothelinen_HK
dc.subjectRenin activityen_HK
dc.subjectUremic cardiomyopathyen_HK
dc.subject.meshAdulten_US
dc.subject.meshAtrial Natriuretic Factor - Blooden_US
dc.subject.meshCardiomegaly - Etiology - Ultrasonographyen_US
dc.subject.meshEchocardiographyen_US
dc.subject.meshEndothelins - Blooden_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshParathyroid Hormone - Blooden_US
dc.subject.meshPeritoneal Dialysis, Continuous Ambulatoryen_US
dc.subject.meshRenin - Blooden_US
dc.subject.meshTime Factorsen_US
dc.subject.meshUremia - Blood - Complications - Therapyen_US
dc.titleVasoactive hormones in uremic patients on continuous ambulatory peritoneal dialysisen_HK
dc.typeArticleen_HK
dc.identifier.emailLai, KN: knlai@hku.hken_HK
dc.identifier.emailLeung, JCK: jckleung@hku.hken_HK
dc.identifier.authorityLai, KN=rp00324en_HK
dc.identifier.authorityLeung, JCK=rp00448en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid1830251-
dc.identifier.scopuseid_2-s2.0-0025729002en_HK
dc.identifier.volume35en_HK
dc.identifier.issue5en_HK
dc.identifier.spage218en_HK
dc.identifier.epage223en_HK
dc.identifier.isiWOS:A1991FM94600006-
dc.publisher.placeMünchen-Deisenhofen, Germanyen_HK
dc.identifier.scopusauthoridLai, KN=7402135706en_HK
dc.identifier.scopusauthoridLi, PKT=25928016800en_HK
dc.identifier.scopusauthoridWoo, KS=7202574149en_HK
dc.identifier.scopusauthoridLui, SF=55066056500en_HK
dc.identifier.scopusauthoridLeung, JCK=7202180349en_HK
dc.identifier.scopusauthoridLaw, E=7102359026en_HK
dc.identifier.scopusauthoridNicholls, MG=7202358024en_HK

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