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Article: Autoradiographic mapping of calcitonin gene-related peptide receptors in human and guinea pig hearts

TitleAutoradiographic mapping of calcitonin gene-related peptide receptors in human and guinea pig hearts
Authors
Issue Date1990
PublisherLippincott Williams & Wilkins. The Journal's web site is located at http://circ.ahajournals.org
Citation
Circulation, 1990, v. 81 n. 3, p. 741-747 How to Cite?
AbstractCalcitonin gene-related peptide (CGRP) is a 37-amino acid peptide that is a potent coronary vasodilator. Although CGRP is found in high concentrations around coronary arteries, its precise function in the control of coronary vasomotor tone remains unclear. We studied the distribution of specific receptors for CGRP in guinea pig and human hearts and found that the highest concentration of specific receptors for CGRP was in the major coronary arteries, which is consistent with the hypothesis that CGRP is implicated in control of coronary vasomotor tone. Areas of coronary artery with atheroma contained significantly decreased (158 ± 35 grains/1,000 μm2 tissue, n = 3) binding sites compared with binding sites in normal arteries (266 ± 10 grains/1,000 μm2 tissue, n = 11; p < 0.001, t test). The decrease in receptors for CGRP around atheroma may predispose these vessels to coronary spasm.
Persistent Identifierhttp://hdl.handle.net/10722/161843
ISSN
2015 Impact Factor: 17.047
2015 SCImago Journal Rankings: 7.853
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorCoupe, MOen_US
dc.contributor.authorMak, JCWen_US
dc.contributor.authorYacoub, Men_US
dc.contributor.authorOldershaw, PJen_US
dc.contributor.authorBarnes, PJen_US
dc.date.accessioned2012-09-05T05:15:26Z-
dc.date.available2012-09-05T05:15:26Z-
dc.date.issued1990en_US
dc.identifier.citationCirculation, 1990, v. 81 n. 3, p. 741-747en_US
dc.identifier.issn0009-7322en_US
dc.identifier.urihttp://hdl.handle.net/10722/161843-
dc.description.abstractCalcitonin gene-related peptide (CGRP) is a 37-amino acid peptide that is a potent coronary vasodilator. Although CGRP is found in high concentrations around coronary arteries, its precise function in the control of coronary vasomotor tone remains unclear. We studied the distribution of specific receptors for CGRP in guinea pig and human hearts and found that the highest concentration of specific receptors for CGRP was in the major coronary arteries, which is consistent with the hypothesis that CGRP is implicated in control of coronary vasomotor tone. Areas of coronary artery with atheroma contained significantly decreased (158 ± 35 grains/1,000 μm2 tissue, n = 3) binding sites compared with binding sites in normal arteries (266 ± 10 grains/1,000 μm2 tissue, n = 11; p < 0.001, t test). The decrease in receptors for CGRP around atheroma may predispose these vessels to coronary spasm.en_US
dc.languageengen_US
dc.publisherLippincott Williams & Wilkins. The Journal's web site is located at http://circ.ahajournals.orgen_US
dc.relation.ispartofCirculationen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAutoradiographyen_US
dc.subject.meshBinding Sitesen_US
dc.subject.meshCalcitonin Gene-Related Peptide - Metabolism - Physiologyen_US
dc.subject.meshCoronary Artery Disease - Metabolismen_US
dc.subject.meshCoronary Vessels - Metabolismen_US
dc.subject.meshGuinea Pigsen_US
dc.subject.meshHumansen_US
dc.subject.meshIodine Radioisotopes - Diagnostic Useen_US
dc.subject.meshMyocardium - Metabolismen_US
dc.subject.meshReceptors, Calcitoninen_US
dc.subject.meshReceptors, Cell Surface - Metabolismen_US
dc.subject.meshVasomotor System - Metabolismen_US
dc.titleAutoradiographic mapping of calcitonin gene-related peptide receptors in human and guinea pig heartsen_US
dc.typeArticleen_US
dc.identifier.emailMak, JCW:judymak@hku.hken_US
dc.identifier.authorityMak, JCW=rp00352en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1161/01.CIR.81.3.741-
dc.identifier.pmid2155072-
dc.identifier.scopuseid_2-s2.0-0025343426en_US
dc.identifier.volume81en_US
dc.identifier.issue3en_US
dc.identifier.spage741en_US
dc.identifier.epage747en_US
dc.identifier.isiWOS:A1990CT01400001-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridCoupe, MO=7003394131en_US
dc.identifier.scopusauthoridMak, JCW=7103323094en_US
dc.identifier.scopusauthoridYacoub, M=36041927900en_US
dc.identifier.scopusauthoridOldershaw, PJ=7003856127en_US
dc.identifier.scopusauthoridBarnes, PJ=36064679400en_US

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