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Article: Interleukin-1β modulates thyrotropin-induced thyroglobulin mRNA transcription through 3',5'-cyclic adenosine monophosphate

TitleInterleukin-1β modulates thyrotropin-induced thyroglobulin mRNA transcription through 3',5'-cyclic adenosine monophosphate
Authors
Issue Date1990
PublisherThe Endocrine Society. The Journal's web site is located at http://endo.endojournals.org
Citation
Endocrinology, 1990, v. 127 n. 3, p. 1369-1374 How to Cite?
AbstractIt has been reported that interleukin-1 possesses not only immunoregulatory action, but also multiple hormone like effects. We studied the action of recombinant interleukin1β (IL-1β) on the synthesis of thyroglobulin (TG), the precursor of thyroid hormone. Human thyrocytes dispersed from normal and Graves' thyroid tissue were incubated with TSH with or without IL-1β. TSH stimulated TG release from cultured human thyrocytes after 4 days. This effect was mimicked by dibutyryl cAMP (dBcAMP). IL-1β had no effect on basal TG release but modulates the TSH-stimulated TG secretion. At low dose (10-5 to 10-3 U/ml) IL-1β increased the TSH-stimulated TG secretion while higher doses (1-100 U/ml) of IL-1β had an inhibitory effect. Similar responses were observed with both normal and Graves' thyrocytes. The effect of IL-1β occurred at the gene transcription level as reflected by changes in TG mRNA level. At 100 U/ml, IL-1β suppressed TG mRNA level to near unmeasurable level. This biphasic effect of IL-1β on TG synthesis is paralleled by a similar change in TSH-stimulated cAMP secretion. We conclude that IL-1β possesses hormonal action on TG gene transcription and its effect is mediated via cAMP.
Persistent Identifierhttp://hdl.handle.net/10722/161831
ISSN
2015 Impact Factor: 4.159
2015 SCImago Journal Rankings: 2.363
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorKung, AWCen_US
dc.contributor.authorLau, KSen_US
dc.date.accessioned2012-09-05T05:15:22Z-
dc.date.available2012-09-05T05:15:22Z-
dc.date.issued1990en_US
dc.identifier.citationEndocrinology, 1990, v. 127 n. 3, p. 1369-1374en_US
dc.identifier.issn0013-7227en_US
dc.identifier.urihttp://hdl.handle.net/10722/161831-
dc.description.abstractIt has been reported that interleukin-1 possesses not only immunoregulatory action, but also multiple hormone like effects. We studied the action of recombinant interleukin1β (IL-1β) on the synthesis of thyroglobulin (TG), the precursor of thyroid hormone. Human thyrocytes dispersed from normal and Graves' thyroid tissue were incubated with TSH with or without IL-1β. TSH stimulated TG release from cultured human thyrocytes after 4 days. This effect was mimicked by dibutyryl cAMP (dBcAMP). IL-1β had no effect on basal TG release but modulates the TSH-stimulated TG secretion. At low dose (10-5 to 10-3 U/ml) IL-1β increased the TSH-stimulated TG secretion while higher doses (1-100 U/ml) of IL-1β had an inhibitory effect. Similar responses were observed with both normal and Graves' thyrocytes. The effect of IL-1β occurred at the gene transcription level as reflected by changes in TG mRNA level. At 100 U/ml, IL-1β suppressed TG mRNA level to near unmeasurable level. This biphasic effect of IL-1β on TG synthesis is paralleled by a similar change in TSH-stimulated cAMP secretion. We conclude that IL-1β possesses hormonal action on TG gene transcription and its effect is mediated via cAMP.en_US
dc.languageengen_US
dc.publisherThe Endocrine Society. The Journal's web site is located at http://endo.endojournals.orgen_US
dc.relation.ispartofEndocrinologyen_US
dc.subject.meshBucladesine - Pharmacologyen_US
dc.subject.meshCells, Cultureden_US
dc.subject.meshCyclic Amp - Biosynthesisen_US
dc.subject.meshGene Expression - Drug Effectsen_US
dc.subject.meshGraves Disease - Metabolismen_US
dc.subject.meshHumansen_US
dc.subject.meshInterleukin-1 - Pharmacologyen_US
dc.subject.meshRna, Messenger - Geneticsen_US
dc.subject.meshRecombinant Proteins - Pharmacologyen_US
dc.subject.meshThyroglobulin - Genetics - Secretionen_US
dc.subject.meshThyroid Gland - Metabolismen_US
dc.subject.meshThyrotropin - Pharmacologyen_US
dc.subject.meshTranscription, Genetic - Drug Effectsen_US
dc.titleInterleukin-1β modulates thyrotropin-induced thyroglobulin mRNA transcription through 3',5'-cyclic adenosine monophosphateen_US
dc.typeArticleen_US
dc.identifier.emailKung, AWC:awckung@hku.hken_US
dc.identifier.authorityKung, AWC=rp00368en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid2167217-
dc.identifier.scopuseid_2-s2.0-0025182138en_US
dc.identifier.volume127en_US
dc.identifier.issue3en_US
dc.identifier.spage1369en_US
dc.identifier.epage1374en_US
dc.identifier.isiWOS:A1990DW29100050-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridKung, AWC=7102322339en_US
dc.identifier.scopusauthoridLau, KS=35205833900en_US

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