File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: T lymphocyte activation in chronic hepatitis B infection: Interleukin 2 release and its receptor expression

TitleT lymphocyte activation in chronic hepatitis B infection: Interleukin 2 release and its receptor expression
Authors
Issue Date1989
PublisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/ajg/index.html
Citation
American Journal Of Gastroenterology, 1989, v. 84 n. 12, p. 1532-1537 How to Cite?
AbstractThe present study was undertaken to examine early T lymphocyte activation in chronic hepatitis B virus (HBV) carriers. Nineteen hepatitis B surface antigen-positive patients (eight with liver cirrhosis and 11 with chronic hepatitis) and 18 healthy controls were studied in a period free of other infection. Mitogen-stimulated cellular interleukin 2 receptor expression, soluble interleukin 2 receptor release, and interleukin 2 production were studied in peripheral blood mononuclear cells cultured for 24 h. No difference was demonstrated between the patients and healthy controls in the cellular interleukin 2 receptor expression, soluble interleukin 2 receptor release, and interleukin 2 production. Pokeweed mitogen-stimulated interleukin 2 production in lymphocytes from cirrhotic patients was significantly lower than that of the noncirrhotic patients. However, the cellular and soluble interleukin 2 receptor levels did not differ between the two groups of chronic HBV carriers. Despite the fact that is has been suggested that autoreactive T cells have a role in mediating the development of chronic liver diseases associated with HBV infection, this study fails to demonstrate a defective T lymphocyte activation in these patients. The observed reduction of interleukin 2 production from activated lymphocytes may be related to the severity of liver impairment, rather than the HBV infection itself.
Persistent Identifierhttp://hdl.handle.net/10722/161810
ISSN
2015 Impact Factor: 10.383
2015 SCImago Journal Rankings: 3.946

 

DC FieldValueLanguage
dc.contributor.authorLai, KNen_HK
dc.contributor.authorLeung, JCKen_HK
dc.contributor.authorTam, JSen_HK
dc.contributor.authorLeung, NWYen_HK
dc.date.accessioned2012-09-05T05:15:13Z-
dc.date.available2012-09-05T05:15:13Z-
dc.date.issued1989en_HK
dc.identifier.citationAmerican Journal Of Gastroenterology, 1989, v. 84 n. 12, p. 1532-1537en_HK
dc.identifier.issn0002-9270en_HK
dc.identifier.urihttp://hdl.handle.net/10722/161810-
dc.description.abstractThe present study was undertaken to examine early T lymphocyte activation in chronic hepatitis B virus (HBV) carriers. Nineteen hepatitis B surface antigen-positive patients (eight with liver cirrhosis and 11 with chronic hepatitis) and 18 healthy controls were studied in a period free of other infection. Mitogen-stimulated cellular interleukin 2 receptor expression, soluble interleukin 2 receptor release, and interleukin 2 production were studied in peripheral blood mononuclear cells cultured for 24 h. No difference was demonstrated between the patients and healthy controls in the cellular interleukin 2 receptor expression, soluble interleukin 2 receptor release, and interleukin 2 production. Pokeweed mitogen-stimulated interleukin 2 production in lymphocytes from cirrhotic patients was significantly lower than that of the noncirrhotic patients. However, the cellular and soluble interleukin 2 receptor levels did not differ between the two groups of chronic HBV carriers. Despite the fact that is has been suggested that autoreactive T cells have a role in mediating the development of chronic liver diseases associated with HBV infection, this study fails to demonstrate a defective T lymphocyte activation in these patients. The observed reduction of interleukin 2 production from activated lymphocytes may be related to the severity of liver impairment, rather than the HBV infection itself.en_HK
dc.languageengen_US
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/ajg/index.htmlen_HK
dc.relation.ispartofAmerican Journal of Gastroenterologyen_HK
dc.subject.meshAdulten_US
dc.subject.meshChronic Diseaseen_US
dc.subject.meshDose-Response Relationship, Immunologicen_US
dc.subject.meshFemaleen_US
dc.subject.meshHepatitis B - Immunology - Metabolismen_US
dc.subject.meshHepatitis B Surface Antigens - Analysisen_US
dc.subject.meshHumansen_US
dc.subject.meshInterleukin-2 - Biosynthesis - Metabolismen_US
dc.subject.meshLiver Cirrhosis - Immunologyen_US
dc.subject.meshLymphocyte Activationen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshReceptors, Interleukin-2 - Analysis - Metabolismen_US
dc.titleT lymphocyte activation in chronic hepatitis B infection: Interleukin 2 release and its receptor expressionen_HK
dc.typeArticleen_HK
dc.identifier.emailLai, KN: knlai@hku.hken_HK
dc.identifier.emailLeung, JCK: jckleung@hku.hken_HK
dc.identifier.authorityLai, KN=rp00324en_HK
dc.identifier.authorityLeung, JCK=rp00448en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid2596455-
dc.identifier.scopuseid_2-s2.0-0024815215en_HK
dc.identifier.volume84en_HK
dc.identifier.issue12en_HK
dc.identifier.spage1532en_HK
dc.identifier.epage1537en_HK
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridLai, KN=7402135706en_HK
dc.identifier.scopusauthoridLeung, JCK=7202180349en_HK
dc.identifier.scopusauthoridTam, JS=24788939600en_HK
dc.identifier.scopusauthoridLeung, NWY=26643107200en_HK

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats