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Article: Reactivity of a new Pan-B monoclonal antibody (MA6) against human leukaemias

TitleReactivity of a new Pan-B monoclonal antibody (MA6) against human leukaemias
Authors
Issue Date1989
PublisherPergamon. The Journal's web site is located at http://www.elsevier.com/locate/leukres
Citation
Leukemia Research, 1989, v. 13 n. 3, p. 241-244 How to Cite?
AbstractThe reactivity of a new Pan-B monoclonal antibody, MA6, against 69 cases of ALL, three plasmacytoma, 10 AML and five CML was evaluated. The antibody reacted positively against five of the 11 cases of U-ALL, 15 of the 26 C-ALL and all the cases of Pre B-ALL (one), B-ALL(one), B-CLL (12) and HCL (two). The MA6 did not react against the 16 cases of T-ALL, three plasmacytoma, 10 AML and five CML. The antibody has a broader spectrum of B-cell reactivity than CD9 and CD20 but is similar to the Pan-B antibody, CD19. MA6 appears to react against some of the very immature B cells and is therefore potentially useful, in conjunction with other antibodies such as CD9 and CD19, to confirm the B-lineage of some cases of U-ALL. The difference in the spectrum of reactivity against B-cell malignancies between MA6 and the other CDw40 antibody, G28-5, confirms their difference in antigenic specificity.
Persistent Identifierhttp://hdl.handle.net/10722/161802
ISSN
2015 Impact Factor: 2.606
2015 SCImago Journal Rankings: 1.043
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorChen, Zen_HK
dc.contributor.authorTang, MHen_HK
dc.contributor.authorChan, KHen_HK
dc.contributor.authorNg, MHen_HK
dc.contributor.authorLiang, Ren_HK
dc.date.accessioned2012-09-05T05:15:10Z-
dc.date.available2012-09-05T05:15:10Z-
dc.date.issued1989en_HK
dc.identifier.citationLeukemia Research, 1989, v. 13 n. 3, p. 241-244en_HK
dc.identifier.issn0145-2126en_HK
dc.identifier.urihttp://hdl.handle.net/10722/161802-
dc.description.abstractThe reactivity of a new Pan-B monoclonal antibody, MA6, against 69 cases of ALL, three plasmacytoma, 10 AML and five CML was evaluated. The antibody reacted positively against five of the 11 cases of U-ALL, 15 of the 26 C-ALL and all the cases of Pre B-ALL (one), B-ALL(one), B-CLL (12) and HCL (two). The MA6 did not react against the 16 cases of T-ALL, three plasmacytoma, 10 AML and five CML. The antibody has a broader spectrum of B-cell reactivity than CD9 and CD20 but is similar to the Pan-B antibody, CD19. MA6 appears to react against some of the very immature B cells and is therefore potentially useful, in conjunction with other antibodies such as CD9 and CD19, to confirm the B-lineage of some cases of U-ALL. The difference in the spectrum of reactivity against B-cell malignancies between MA6 and the other CDw40 antibody, G28-5, confirms their difference in antigenic specificity.en_HK
dc.languageengen_US
dc.publisherPergamon. The Journal's web site is located at http://www.elsevier.com/locate/leukresen_HK
dc.relation.ispartofLeukemia Researchen_HK
dc.subject.meshAntibodies, Monoclonal - Immunologyen_US
dc.subject.meshB-Lymphocytes - Immunologyen_US
dc.subject.meshFluorescent Antibody Techniqueen_US
dc.subject.meshHumansen_US
dc.subject.meshLeukemia - Immunologyen_US
dc.titleReactivity of a new Pan-B monoclonal antibody (MA6) against human leukaemiasen_HK
dc.typeArticleen_HK
dc.identifier.emailTang, MH: mhytang@hkucc.hku.hken_HK
dc.identifier.emailLiang, R: rliang@hku.hken_HK
dc.identifier.authorityTang, MH=rp01701en_HK
dc.identifier.authorityLiang, R=rp00345en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/0145-2126(89)90018-0-
dc.identifier.pmid2651812-
dc.identifier.scopuseid_2-s2.0-0024573906en_HK
dc.identifier.volume13en_HK
dc.identifier.issue3en_HK
dc.identifier.spage241en_HK
dc.identifier.epage244en_HK
dc.identifier.isiWOS:A1989U248800008-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridChen, Z=7409484038en_HK
dc.identifier.scopusauthoridTang, MH=8943401300en_HK
dc.identifier.scopusauthoridChan, KH=35338760600en_HK
dc.identifier.scopusauthoridNg, MH=7202076421en_HK
dc.identifier.scopusauthoridLiang, R=26643224900en_HK

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