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Article: Treatment of adult acute lymphoblastic leukaemia using an intensive chemotherapy protocol

TitleTreatment of adult acute lymphoblastic leukaemia using an intensive chemotherapy protocol
Authors
Issue Date1989
PublisherSpringer. The Journal's web site is located at http://www.springer.com/medicine/oncology/journal/280
Citation
Cancer Chemotherapy And Pharmacology, 1989, v. 23 n. 6, p. 384-388 How to Cite?
AbstractA total of 25 evaluable adult patients with acute lymphoblastic leukaemia (ALL) were treated with an intensive chemotherapy regime modified from the L17/L17M protocol of the Sloan-Kettering Hospital. There were 18 men and 7 women; their median age was 36 years (range, 13-78). Seven cases had L1 morphology and 18, L2. The immunophenotype was common-ALL in 10, null-ALL in 9, T-ALL in 4 and B-ALL in 1. Of the 25 patients, 14 (56%) achieved a complete remission (CR). The causes of induction failure were partial remission (PR) only in 7 (28%) and hypoplastic death in 4 (16%). Of the 14 CR patients, 11 (78.6%) relapsed. Five patients developed CNS disease. The median disease-free survival and overall survival were only 9 and 13 months, respectively. As the follow-up periods of the surviving patients were short, late relapses may still occur and the overall treatment result is likely to be worse on longer follow-up. The possible causes of this disappointing result are discussed.
Persistent Identifierhttp://hdl.handle.net/10722/161800
ISSN
2015 Impact Factor: 2.824
2015 SCImago Journal Rankings: 1.283
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLiang, Ren_US
dc.contributor.authorChan, TKen_US
dc.contributor.authorChan, GTCen_US
dc.contributor.authorTodd, Den_US
dc.date.accessioned2012-09-05T05:15:07Z-
dc.date.available2012-09-05T05:15:07Z-
dc.date.issued1989en_US
dc.identifier.citationCancer Chemotherapy And Pharmacology, 1989, v. 23 n. 6, p. 384-388en_US
dc.identifier.issn0344-5704en_US
dc.identifier.urihttp://hdl.handle.net/10722/161800-
dc.description.abstractA total of 25 evaluable adult patients with acute lymphoblastic leukaemia (ALL) were treated with an intensive chemotherapy regime modified from the L17/L17M protocol of the Sloan-Kettering Hospital. There were 18 men and 7 women; their median age was 36 years (range, 13-78). Seven cases had L1 morphology and 18, L2. The immunophenotype was common-ALL in 10, null-ALL in 9, T-ALL in 4 and B-ALL in 1. Of the 25 patients, 14 (56%) achieved a complete remission (CR). The causes of induction failure were partial remission (PR) only in 7 (28%) and hypoplastic death in 4 (16%). Of the 14 CR patients, 11 (78.6%) relapsed. Five patients developed CNS disease. The median disease-free survival and overall survival were only 9 and 13 months, respectively. As the follow-up periods of the surviving patients were short, late relapses may still occur and the overall treatment result is likely to be worse on longer follow-up. The possible causes of this disappointing result are discussed.en_US
dc.languageengen_US
dc.publisherSpringer. The Journal's web site is located at http://www.springer.com/medicine/oncology/journal/280en_US
dc.relation.ispartofCancer Chemotherapy and Pharmacologyen_US
dc.subject.meshAdulten_US
dc.subject.meshAntineoplastic Combined Chemotherapy Protocols - Therapeutic Useen_US
dc.subject.meshBrain Neoplasms - Prevention & Control - Radiotherapy - Secondaryen_US
dc.subject.meshFemaleen_US
dc.subject.meshFollow-Up Studiesen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshPrecursor Cell Lymphoblastic Leukemia-Lymphoma - Drug Therapyen_US
dc.subject.meshPrognosisen_US
dc.titleTreatment of adult acute lymphoblastic leukaemia using an intensive chemotherapy protocolen_US
dc.typeArticleen_US
dc.identifier.emailLiang, R:rliang@hku.hken_US
dc.identifier.authorityLiang, R=rp00345en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1007/BF00435841-
dc.identifier.pmid2713959-
dc.identifier.scopuseid_2-s2.0-0024561627en_US
dc.identifier.volume23en_US
dc.identifier.issue6en_US
dc.identifier.spage384en_US
dc.identifier.epage388en_US
dc.identifier.isiWOS:A1989U322900010-
dc.publisher.placeGermanyen_US
dc.identifier.scopusauthoridLiang, R=26643224900en_US
dc.identifier.scopusauthoridChan, TK=7402687762en_US
dc.identifier.scopusauthoridChan, GTC=7202355262en_US
dc.identifier.scopusauthoridTodd, D=7201388182en_US

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