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Article: Central nervous system involvement in non-Hodgkin's lymphoma

TitleCentral nervous system involvement in non-Hodgkin's lymphoma
Authors
Issue Date1989
Citation
European Journal Of Cancer And Clinical Oncology, 1989, v. 25 n. 4, p. 703-710 How to Cite?
AbstractFifty-eight Hong Kong Chinese patients with CNS lymphoma were reviewed (primary seven, secondary 51). The incidence of secondary CNS lymphoma in patients with non-Hodgkin's lymphoma was estimated to be 9.4%. The Working Formulation separated subtypes which had a special propensity to involve the CNS. Significant proportions of our patients with secondary CNS lymphoma had other features which were known to be associated with a high risk of CNS disease including stage IV (48/51, 91.4%), bone marrow (26/51, 50.9%), peripheral blood (7.51, 13.7%), nasal (7/51, 13.7%), orbital (3/51, 5.9%), testicular (2/51, 3.9%) and bulky retroperitoneal (6/51, 11.8%) disease. 82% of patients with secondary CNS lymphoma had concurrent systemic disease and a further 12% had systemic relapse shortly afterward. CNS lymphoma is associated with poor prognosis and only 29% and 14% of the patients with primary and secondary CNS lymphoma respectively survived beyond 1 year. Patients responding to therapy had significantly better survival. 69.9% of the deaths were related to progressive systemic disease.
Persistent Identifierhttp://hdl.handle.net/10722/161793
ISSN
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLiang, RHSen_US
dc.contributor.authorWoo, EKWen_US
dc.contributor.authorYu, YLen_US
dc.contributor.authorTodd, Den_US
dc.contributor.authorChan, TKen_US
dc.contributor.authorHo, FCSen_US
dc.contributor.authorTso, SCen_US
dc.contributor.authorShum, JSTen_US
dc.date.accessioned2012-09-05T05:15:05Z-
dc.date.available2012-09-05T05:15:05Z-
dc.date.issued1989en_US
dc.identifier.citationEuropean Journal Of Cancer And Clinical Oncology, 1989, v. 25 n. 4, p. 703-710en_US
dc.identifier.issn0277-5379en_US
dc.identifier.urihttp://hdl.handle.net/10722/161793-
dc.description.abstractFifty-eight Hong Kong Chinese patients with CNS lymphoma were reviewed (primary seven, secondary 51). The incidence of secondary CNS lymphoma in patients with non-Hodgkin's lymphoma was estimated to be 9.4%. The Working Formulation separated subtypes which had a special propensity to involve the CNS. Significant proportions of our patients with secondary CNS lymphoma had other features which were known to be associated with a high risk of CNS disease including stage IV (48/51, 91.4%), bone marrow (26/51, 50.9%), peripheral blood (7.51, 13.7%), nasal (7/51, 13.7%), orbital (3/51, 5.9%), testicular (2/51, 3.9%) and bulky retroperitoneal (6/51, 11.8%) disease. 82% of patients with secondary CNS lymphoma had concurrent systemic disease and a further 12% had systemic relapse shortly afterward. CNS lymphoma is associated with poor prognosis and only 29% and 14% of the patients with primary and secondary CNS lymphoma respectively survived beyond 1 year. Patients responding to therapy had significantly better survival. 69.9% of the deaths were related to progressive systemic disease.en_US
dc.languageengen_US
dc.relation.ispartofEuropean Journal of Cancer and Clinical Oncologyen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshAged, 80 And Overen_US
dc.subject.meshBrain Neoplasms - Diagnosis - Mortality - Therapyen_US
dc.subject.meshChilden_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshLymphoma, Non-Hodgkin - Diagnosis - Mortality - Therapyen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshRetrospective Studiesen_US
dc.subject.meshSpinal Cord Neoplasms - Diagnosis - Mortality - Therapyen_US
dc.titleCentral nervous system involvement in non-Hodgkin's lymphomaen_US
dc.typeArticleen_US
dc.identifier.emailLiang, RHS:rliang@hku.hken_US
dc.identifier.authorityLiang, RHS=rp00345en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/0277-5379(89)90207-1-
dc.identifier.pmid2714346-
dc.identifier.scopuseid_2-s2.0-0024511557en_US
dc.identifier.volume25en_US
dc.identifier.issue4en_US
dc.identifier.spage703en_US
dc.identifier.epage710en_US
dc.identifier.isiWOS:A1989U077100019-
dc.identifier.scopusauthoridLiang, RHS=26643224900en_US
dc.identifier.scopusauthoridWoo, EKW=7103371219en_US
dc.identifier.scopusauthoridYu, YL=8094845300en_US
dc.identifier.scopusauthoridTodd, D=7201388182en_US
dc.identifier.scopusauthoridChan, TK=7402687762en_US
dc.identifier.scopusauthoridHo, FCS=7103408147en_US
dc.identifier.scopusauthoridTso, SC=7103261600en_US
dc.identifier.scopusauthoridShum, JST=6603349555en_US

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