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Article: Muscarinic receptor subtypes mediating vasodilation in the pulmonary artery

TitleMuscarinic receptor subtypes mediating vasodilation in the pulmonary artery
Authors
Issue Date1988
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/ejphar
Citation
European Journal Of Pharmacology, 1988, v. 158 n. 3, p. 293-297 How to Cite?
AbstractBinding studies in several species have demonstrated a high proportion of M1 muscarinic receptors in the lung but their localization is uncertain. Using [3H]quinuclidinyl benzylate we have confirmed that binding sites with high affinity for pirenzepine account for 50% of muscarinic receptors in the rat lung. Our functional studies using the muscarinic antagonists 4-diphenylacetoxy-N-methylpiperidine (4-DAMP), methoctramine and pirenzepine have demonstrated that the muscarinic receptor on the rat pulmonary artery endothelium which mediates vasodilation is of the M3 subtype and cannot acount for the high proportion of M1 receptors identified in lung homogenates.
Persistent Identifierhttp://hdl.handle.net/10722/161769
ISSN
2015 Impact Factor: 2.73
2015 SCImago Journal Rankings: 1.115
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorMccormack, DGen_US
dc.contributor.authorMak, JCen_US
dc.contributor.authorMinette, Pen_US
dc.contributor.authorBarnes, PJen_US
dc.date.accessioned2012-09-05T05:14:47Z-
dc.date.available2012-09-05T05:14:47Z-
dc.date.issued1988en_US
dc.identifier.citationEuropean Journal Of Pharmacology, 1988, v. 158 n. 3, p. 293-297en_US
dc.identifier.issn0014-2999en_US
dc.identifier.urihttp://hdl.handle.net/10722/161769-
dc.description.abstractBinding studies in several species have demonstrated a high proportion of M1 muscarinic receptors in the lung but their localization is uncertain. Using [3H]quinuclidinyl benzylate we have confirmed that binding sites with high affinity for pirenzepine account for 50% of muscarinic receptors in the rat lung. Our functional studies using the muscarinic antagonists 4-diphenylacetoxy-N-methylpiperidine (4-DAMP), methoctramine and pirenzepine have demonstrated that the muscarinic receptor on the rat pulmonary artery endothelium which mediates vasodilation is of the M3 subtype and cannot acount for the high proportion of M1 receptors identified in lung homogenates.en_US
dc.languageengen_US
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/ejpharen_US
dc.relation.ispartofEuropean Journal of Pharmacologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshBinding Sites - Drug Effectsen_US
dc.subject.meshCell Membrane - Metabolismen_US
dc.subject.meshDiamines - Pharmacologyen_US
dc.subject.meshEndothelium, Vascular - Drug Effectsen_US
dc.subject.meshLung - Drug Effects - Metabolismen_US
dc.subject.meshMaleen_US
dc.subject.meshPiperidines - Pharmacologyen_US
dc.subject.meshPirenzepine - Pharmacologyen_US
dc.subject.meshPulmonary Artery - Drug Effects - Metabolismen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Inbred Strainsen_US
dc.subject.meshReceptors, Muscarinic - Classification - Drug Effects - Metabolismen_US
dc.subject.meshVasodilation - Drug Effectsen_US
dc.titleMuscarinic receptor subtypes mediating vasodilation in the pulmonary arteryen_US
dc.typeArticleen_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/0014-2999(88)90083-0-
dc.identifier.pmid3253104-
dc.identifier.scopuseid_2-s2.0-0024217607en_US
dc.identifier.volume158en_US
dc.identifier.issue3en_US
dc.identifier.spage293en_US
dc.identifier.epage297en_US
dc.identifier.isiWOS:A1988R712200019-
dc.publisher.placeNetherlandsen_US

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