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Article: Restriction fragment length polymorphism in the interzeta hypervariable region for prenatal diagnosis of non-deletion α thalassemia

TitleRestriction fragment length polymorphism in the interzeta hypervariable region for prenatal diagnosis of non-deletion α thalassemia
Authors
Issue Date1988
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/35105
Citation
American Journal Of Hematology, 1988, v. 27 n. 4, p. 242-246 How to Cite?
AbstractA Bam Hi restriction fragment length polymorphism in the interzeta hypervariable region (IZ HR+) of the ζ-α gene cluster was used for the prenatal diagnosis of a pregnancy at risk for Hb H hydrops fetalis. The parents had ζ-α thalassemia 1 and non-deletion α thalassemia, respectively, and a previous hydrops was missed using the conventional method of gene detection. In this prenatal diagnosis, linkage to IZ HVR was used to exclude non-deletion α thalassemia, and the numbers of ζ and α genes in the fetus were quantitated to predict the exact genotype. Confirmation was made by analysis of cord blood at delivery.
Persistent Identifierhttp://hdl.handle.net/10722/161762
ISSN
2015 Impact Factor: 5.0
2015 SCImago Journal Rankings: 1.761
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorChan, Ven_US
dc.contributor.authorChan, TKen_US
dc.contributor.authorWong, ACKen_US
dc.contributor.authorChan, TPTen_US
dc.contributor.authorGhosh, Aen_US
dc.contributor.authorTodd, Den_US
dc.date.accessioned2012-09-05T05:14:44Z-
dc.date.available2012-09-05T05:14:44Z-
dc.date.issued1988en_US
dc.identifier.citationAmerican Journal Of Hematology, 1988, v. 27 n. 4, p. 242-246en_US
dc.identifier.issn0361-8609en_US
dc.identifier.urihttp://hdl.handle.net/10722/161762-
dc.description.abstractA Bam Hi restriction fragment length polymorphism in the interzeta hypervariable region (IZ HR+) of the ζ-α gene cluster was used for the prenatal diagnosis of a pregnancy at risk for Hb H hydrops fetalis. The parents had ζ-α thalassemia 1 and non-deletion α thalassemia, respectively, and a previous hydrops was missed using the conventional method of gene detection. In this prenatal diagnosis, linkage to IZ HVR was used to exclude non-deletion α thalassemia, and the numbers of ζ and α genes in the fetus were quantitated to predict the exact genotype. Confirmation was made by analysis of cord blood at delivery.en_US
dc.languageengen_US
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/35105en_US
dc.relation.ispartofAmerican Journal of Hematologyen_US
dc.subject.meshAmniocentesisen_US
dc.subject.meshChromosome Deletionen_US
dc.subject.meshDna Restriction Enzymesen_US
dc.subject.meshDeoxyribonuclease Bamhien_US
dc.subject.meshFemaleen_US
dc.subject.meshGenesen_US
dc.subject.meshGenetic Variationen_US
dc.subject.meshGenotypeen_US
dc.subject.meshHemoglobins - Geneticsen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshPedigreeen_US
dc.subject.meshPolymorphism, Geneticen_US
dc.subject.meshPolymorphism, Restriction Fragment Lengthen_US
dc.subject.meshPregnancyen_US
dc.subject.meshPrenatal Diagnosisen_US
dc.subject.meshThalassemia - Diagnosis - Geneticsen_US
dc.titleRestriction fragment length polymorphism in the interzeta hypervariable region for prenatal diagnosis of non-deletion α thalassemiaen_US
dc.typeArticleen_US
dc.identifier.emailChan, V:vnychana@hkucc.hku.hken_US
dc.identifier.authorityChan, V=rp00320en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1002/ajh.2830270403-
dc.identifier.pmid2895581-
dc.identifier.scopuseid_2-s2.0-0023893079en_US
dc.identifier.volume27en_US
dc.identifier.issue4en_US
dc.identifier.spage242en_US
dc.identifier.epage246en_US
dc.identifier.isiWOS:A1988M914700002-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridChan, V=7202654865en_US
dc.identifier.scopusauthoridChan, TK=7402687762en_US
dc.identifier.scopusauthoridWong, ACK=7403147528en_US
dc.identifier.scopusauthoridChan, TPT=7402687517en_US
dc.identifier.scopusauthoridGhosh, A=7403963873en_US
dc.identifier.scopusauthoridTodd, D=7201388182en_US

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