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Article: Ultrasound evaluation of pregnancies at risk for homozygous alpha-thalassaemia-1.

TitleUltrasound evaluation of pregnancies at risk for homozygous alpha-thalassaemia-1.
Authors
Issue Date1987
PublisherJohn Wiley & Sons Ltd. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/2252
Citation
Prenatal Diagnosis, 1987, v. 7 n. 5, p. 307-313 How to Cite?
AbstractTwenty-six pregnant Chinese women who were at risk of giving birth to a fetus affected with homozygous alpha-thalassaemia-1 were examined serially by ultrasound. Six of these 26 pregnancies were affected. In one third of the affected pregnancies progressive fetal ascites appeared before 24 weeks gestation and these pregnancies were terminated. In the remaining two thirds abnormal estimated fetal weight-placental volume (EFW-PV) ratio and fetal growth retardation as evidenced by a falling biparietal diameter (BPD), femur length (FL) but a normal abdominal circumference (AC) was apparent by 28 weeks gestation. Increased transverse cardiac (TC) diameter was another consistent finding but appeared late. All these features appeared before the onset of fetal ascites. A normal EFW-PV ratio and fetal growth until 28 weeks gestation was a reassuring sign of normality. Abnormal EFW-PV ratio was the earliest sign to appear in affected pregnancies and a normal ratio until 28 weeks gestation had a 100 per cent predictive value.
Persistent Identifierhttp://hdl.handle.net/10722/161733
ISSN
2015 Impact Factor: 3.043
2015 SCImago Journal Rankings: 1.450
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorGhosh, Aen_HK
dc.contributor.authorTang, MHen_HK
dc.contributor.authorLiang, STen_HK
dc.contributor.authorMa, HKen_HK
dc.contributor.authorChan, Ven_HK
dc.contributor.authorChan, TKen_HK
dc.date.accessioned2012-09-05T05:14:31Z-
dc.date.available2012-09-05T05:14:31Z-
dc.date.issued1987en_HK
dc.identifier.citationPrenatal Diagnosis, 1987, v. 7 n. 5, p. 307-313en_HK
dc.identifier.issn0197-3851en_HK
dc.identifier.urihttp://hdl.handle.net/10722/161733-
dc.description.abstractTwenty-six pregnant Chinese women who were at risk of giving birth to a fetus affected with homozygous alpha-thalassaemia-1 were examined serially by ultrasound. Six of these 26 pregnancies were affected. In one third of the affected pregnancies progressive fetal ascites appeared before 24 weeks gestation and these pregnancies were terminated. In the remaining two thirds abnormal estimated fetal weight-placental volume (EFW-PV) ratio and fetal growth retardation as evidenced by a falling biparietal diameter (BPD), femur length (FL) but a normal abdominal circumference (AC) was apparent by 28 weeks gestation. Increased transverse cardiac (TC) diameter was another consistent finding but appeared late. All these features appeared before the onset of fetal ascites. A normal EFW-PV ratio and fetal growth until 28 weeks gestation was a reassuring sign of normality. Abnormal EFW-PV ratio was the earliest sign to appear in affected pregnancies and a normal ratio until 28 weeks gestation had a 100 per cent predictive value.en_HK
dc.languageengen_US
dc.publisherJohn Wiley & Sons Ltd. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/2252en_HK
dc.relation.ispartofPrenatal Diagnosisen_HK
dc.subject.meshFemaleen_US
dc.subject.meshFetus - Pathologyen_US
dc.subject.meshHomozygoteen_US
dc.subject.meshHumansen_US
dc.subject.meshOrgan Sizeen_US
dc.subject.meshPlacenta - Pathologyen_US
dc.subject.meshPregnancyen_US
dc.subject.meshPregnancy Complications, Hematologic - Diagnosisen_US
dc.subject.meshPrenatal Diagnosisen_US
dc.subject.meshThalassemia - Diagnosis - Geneticsen_US
dc.subject.meshUltrasonographyen_US
dc.titleUltrasound evaluation of pregnancies at risk for homozygous alpha-thalassaemia-1.en_HK
dc.typeArticleen_HK
dc.identifier.emailTang, MH: mhytang@hkucc.hku.hken_HK
dc.identifier.emailChan, V: vnychana@hkucc.hku.hken_HK
dc.identifier.authorityTang, MH=rp01701en_HK
dc.identifier.authorityChan, V=rp00320en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1002/pd.1970070503-
dc.identifier.pmid3303005-
dc.identifier.scopuseid_2-s2.0-0023353418en_HK
dc.identifier.volume7en_HK
dc.identifier.issue5en_HK
dc.identifier.spage307en_HK
dc.identifier.epage313en_HK
dc.identifier.isiWOS:A1987H901400001-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridGhosh, A=7403963873en_HK
dc.identifier.scopusauthoridTang, MH=8943401300en_HK
dc.identifier.scopusauthoridLiang, ST=7402146735en_HK
dc.identifier.scopusauthoridMa, HK=7403095603en_HK
dc.identifier.scopusauthoridChan, V=7202654865en_HK
dc.identifier.scopusauthoridChan, TK=7402687762en_HK

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