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Article: Organization of the ζ-α genes in Chinese

TitleOrganization of the ζ-α genes in Chinese
Authors
Issue Date1986
PublisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/BJH
Citation
British Journal Of Haematology, 1986, v. 64 n. 1, p. 97-105 How to Cite?
AbstractAnalysis of α and ζ genes in 101 healthy normals and hospitalized patients with non-haematological diseases revealed a 3% incidence of α thalassaemia in the local Chinese population of Hong Kong. Triple α genes were found in only one person while triple ζ genes were more prevalent, occurring in 13 subjects. Studies of 28 unselected patients with Hb H disease indicated a predominance of the rightward α gene deletion. The extent of α gene deletion in homozygous α thalassaemia 1 was at least 18.1 kb, beginning from the BamH I site 3' to the ζ1 gene and includes the ψα, α2 and α1 genes. Nineteen of the 20 chromosomes bearing the α thalassaemia 1 deletion had identical ζ-intergenic hypervariable region suggesting a common origin of this mutation. The co-inheritance of α thalassaemia in β thalassaemia subjects was 8%, but did not ameliorate the clinical features of those with homozygous β thalassaemia.
Persistent Identifierhttp://hdl.handle.net/10722/161699
ISSN
2015 Impact Factor: 5.401
2015 SCImago Journal Rankings: 2.313
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorChan, Ven_US
dc.contributor.authorChan, TKen_US
dc.contributor.authorCheng, MYen_US
dc.date.accessioned2012-09-05T05:14:10Z-
dc.date.available2012-09-05T05:14:10Z-
dc.date.issued1986en_US
dc.identifier.citationBritish Journal Of Haematology, 1986, v. 64 n. 1, p. 97-105en_US
dc.identifier.issn0007-1048en_US
dc.identifier.urihttp://hdl.handle.net/10722/161699-
dc.description.abstractAnalysis of α and ζ genes in 101 healthy normals and hospitalized patients with non-haematological diseases revealed a 3% incidence of α thalassaemia in the local Chinese population of Hong Kong. Triple α genes were found in only one person while triple ζ genes were more prevalent, occurring in 13 subjects. Studies of 28 unselected patients with Hb H disease indicated a predominance of the rightward α gene deletion. The extent of α gene deletion in homozygous α thalassaemia 1 was at least 18.1 kb, beginning from the BamH I site 3' to the ζ1 gene and includes the ψα, α2 and α1 genes. Nineteen of the 20 chromosomes bearing the α thalassaemia 1 deletion had identical ζ-intergenic hypervariable region suggesting a common origin of this mutation. The co-inheritance of α thalassaemia in β thalassaemia subjects was 8%, but did not ameliorate the clinical features of those with homozygous β thalassaemia.en_US
dc.languageengen_US
dc.publisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/BJHen_US
dc.relation.ispartofBritish Journal of Haematologyen_US
dc.subject.meshChina - Ethnologyen_US
dc.subject.meshChromosome Deletionen_US
dc.subject.meshChromosome Mappingen_US
dc.subject.meshChromosomes, Human, 16-18en_US
dc.subject.meshGlobins - Geneticsen_US
dc.subject.meshHeterozygoteen_US
dc.subject.meshHomozygoteen_US
dc.subject.meshHong Kongen_US
dc.subject.meshHumansen_US
dc.subject.meshThalassemia - Geneticsen_US
dc.titleOrganization of the ζ-α genes in Chineseen_US
dc.typeArticleen_US
dc.identifier.emailChan, V:vnychana@hkucc.hku.hken_US
dc.identifier.authorityChan, V=rp00320en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1111/j.1365-2141.1986.tb07577.x-
dc.identifier.pmid3756105-
dc.identifier.scopuseid_2-s2.0-0022476657en_US
dc.identifier.volume64en_US
dc.identifier.issue1en_US
dc.identifier.spage97en_US
dc.identifier.epage105en_US
dc.identifier.isiWOS:A1986D906100010-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridChan, V=7202654865en_US
dc.identifier.scopusauthoridChan, TK=7402687762en_US
dc.identifier.scopusauthoridCheng, MY=7402260595en_US

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