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Article: Association of HLA antigens with thyrotoxic Graves' disease and periodic paralysis in Hong Kong Chinese

TitleAssociation of HLA antigens with thyrotoxic Graves' disease and periodic paralysis in Hong Kong Chinese
Authors
Issue Date1985
PublisherWiley-Blackwell Publishing Ltd.. The Journal's web site is located at http://www.wiley.com/bw/journal.asp?ref=0300-0664
Citation
Clinical Endocrinology, 1985, v. 23 n. 3, p. 245-252 How to Cite?
AbstractThe HLA-A and -B antigen distribution in 132 Hong Kong Chinese patients with Graves' disease, including 24 with thyrotoxic periodic paralysis, was compared with that in 10 controls. The HLA-DR antigen distribution in 68 patients was compared with that in 47 controls. The prevalence of Bw46 was significantly increased in patients with Graves' disease and with periodic paralysis. The prevalence of DRw9 was also slightly increased but not at a statistically significant level. The high prevalence of Bw46 related to patients with early age at onset whereas patients with later age at onset had a significantly increased prevalence of HLA B5. It is suggested that Graves' disease in Chinese is due to two HLA-associated mechanisms in which early-onset disease is associated with Bw46 and late-onset disease with B5.
Persistent Identifierhttp://hdl.handle.net/10722/161694
ISSN
2015 Impact Factor: 3.487
2015 SCImago Journal Rankings: 1.314
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorHawkins, BRen_US
dc.contributor.authorMa, JTCen_US
dc.contributor.authorLam, KSLen_US
dc.date.accessioned2012-09-05T05:14:08Z-
dc.date.available2012-09-05T05:14:08Z-
dc.date.issued1985en_US
dc.identifier.citationClinical Endocrinology, 1985, v. 23 n. 3, p. 245-252en_US
dc.identifier.issn0300-0664en_US
dc.identifier.urihttp://hdl.handle.net/10722/161694-
dc.description.abstractThe HLA-A and -B antigen distribution in 132 Hong Kong Chinese patients with Graves' disease, including 24 with thyrotoxic periodic paralysis, was compared with that in 10 controls. The HLA-DR antigen distribution in 68 patients was compared with that in 47 controls. The prevalence of Bw46 was significantly increased in patients with Graves' disease and with periodic paralysis. The prevalence of DRw9 was also slightly increased but not at a statistically significant level. The high prevalence of Bw46 related to patients with early age at onset whereas patients with later age at onset had a significantly increased prevalence of HLA B5. It is suggested that Graves' disease in Chinese is due to two HLA-associated mechanisms in which early-onset disease is associated with Bw46 and late-onset disease with B5.en_US
dc.languageengen_US
dc.publisherWiley-Blackwell Publishing Ltd.. The Journal's web site is located at http://www.wiley.com/bw/journal.asp?ref=0300-0664en_US
dc.relation.ispartofClinical Endocrinologyen_US
dc.titleAssociation of HLA antigens with thyrotoxic Graves' disease and periodic paralysis in Hong Kong Chineseen_US
dc.typeArticleen_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1111/j.1365-2265.1985.tb00220.x-
dc.identifier.pmid3865750-
dc.identifier.scopuseid_2-s2.0-0022372353en_US
dc.identifier.volume23en_US
dc.identifier.issue3en_US
dc.identifier.spage245en_US
dc.identifier.epage252en_US
dc.identifier.isiWOS:A1985ASD2300004-
dc.publisher.placeUnited Kingdomen_US

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