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Article: Hypofibrinogenemia due to increased fibrinolysis in two patients with acute promyelocytic leukemia

TitleHypofibrinogenemia due to increased fibrinolysis in two patients with acute promyelocytic leukemia
Authors
Issue Date1984
PublisherBlackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/IMJ
Citation
Australian And New Zealand Journal Of Medicine, 1984, v. 14 n. 3, p. 245-249 How to Cite?
AbstractTwo patients with acute promyelocytic leukemia and severe bleeding associated with hypofibrinogenemia were studied. The markedly shortened whole blood clot lysis time and dilute clot lysis time suggested that the defect was an increase in fibrinolysis. Although disseminated intravascular coagulation could not be totally excluded as an alternative mechanism, excessive fibrinolysis was confirmed as the pathogenic cause by the prompt response to the administration of tranexamic acid. The low circulating plasminogen, α 2 plasmin inhibitor level and the presence of α 2 plasmin inhibitor-protease complex in both patients suggested that the increased fibrinolysis probably resulted from the liberation of plasminogen activator from the promyelocyte.
Persistent Identifierhttp://hdl.handle.net/10722/161682
ISSN
2002 Impact Factor: 0.524
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorChan, TKen_US
dc.contributor.authorChan, GTCen_US
dc.contributor.authorChan, Ven_US
dc.date.accessioned2012-09-05T05:13:52Z-
dc.date.available2012-09-05T05:13:52Z-
dc.date.issued1984en_US
dc.identifier.citationAustralian And New Zealand Journal Of Medicine, 1984, v. 14 n. 3, p. 245-249en_US
dc.identifier.issn0004-8291en_US
dc.identifier.urihttp://hdl.handle.net/10722/161682-
dc.description.abstractTwo patients with acute promyelocytic leukemia and severe bleeding associated with hypofibrinogenemia were studied. The markedly shortened whole blood clot lysis time and dilute clot lysis time suggested that the defect was an increase in fibrinolysis. Although disseminated intravascular coagulation could not be totally excluded as an alternative mechanism, excessive fibrinolysis was confirmed as the pathogenic cause by the prompt response to the administration of tranexamic acid. The low circulating plasminogen, α 2 plasmin inhibitor level and the presence of α 2 plasmin inhibitor-protease complex in both patients suggested that the increased fibrinolysis probably resulted from the liberation of plasminogen activator from the promyelocyte.en_US
dc.languageengen_US
dc.publisherBlackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/IMJen_US
dc.relation.ispartofAustralian and New Zealand Journal of Medicineen_US
dc.subject.meshAdulten_US
dc.subject.meshAfibrinogenemia - Etiologyen_US
dc.subject.meshAntibiotics, Antineoplasticen_US
dc.subject.meshBlood Coagulation Testsen_US
dc.subject.meshDiagnosis, Differentialen_US
dc.subject.meshDisseminated Intravascular Coagulation - Complicationsen_US
dc.subject.meshFemaleen_US
dc.subject.meshFibrinogen - Therapeutic Useen_US
dc.subject.meshFibrinolysisen_US
dc.subject.meshHumansen_US
dc.subject.meshLeukemia, Myeloid, Acute - Complicationsen_US
dc.subject.meshMaleen_US
dc.subject.meshNaphthacenes - Therapeutic Useen_US
dc.subject.meshTranexamic Acid - Therapeutic Useen_US
dc.titleHypofibrinogenemia due to increased fibrinolysis in two patients with acute promyelocytic leukemiaen_US
dc.typeArticleen_US
dc.identifier.emailChan, V:vnychana@hkucc.hku.hken_US
dc.identifier.authorityChan, V=rp00320en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1111/j.1445-5994.1984.tb03760.x-
dc.identifier.pmid6594115-
dc.identifier.scopuseid_2-s2.0-0021746072en_US
dc.identifier.volume14en_US
dc.identifier.issue3en_US
dc.identifier.spage245en_US
dc.identifier.epage249en_US
dc.identifier.isiWOS:A1984SZ88400010-
dc.publisher.placeAustraliaen_US
dc.identifier.scopusauthoridChan, TK=7402687762en_US
dc.identifier.scopusauthoridChan, GTC=7202355262en_US
dc.identifier.scopusauthoridChan, V=7202654865en_US

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