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Article: BamH I polymorphism in the Chinese: Its potential usefulness in prenatal diagnosis of β thalassaemia

TitleBamH I polymorphism in the Chinese: Its potential usefulness in prenatal diagnosis of β thalassaemia
Authors
Chan, VLeung, NKChan, TK
Issue Date1984
Citation
British Medical Journal, 1984, v. 289 n. 6450, p. 947-948 How to Cite?
DOI: http://dx.doi.org/10.1136/bmj.289.6450.947
AbstractThe prevalence of the BamH I site 3' to the β globin gene in Chinese people was determined in 123 normal subjects, 40 patients with heterozygous β thalassaemia, and 25 patients with homozygous β thalassaemia. The site was present in 71.1% and absent in 28.9% of the chromosomes carrying normal β genes. All 25 patients with β thalassaemia major had the site. This BamH I polymorphism may be used for prenatal diagnosis in about 29% of the pregnancies at risk.
Persistent Identifierhttp://hdl.handle.net/10722/161674
ISSN
0959-8146
2023 SCImago Journal Rankings: 2.803
ISI Accession Number ID
WOS:A1984TM39100009

 

DC FieldValueLanguage
dc.contributor.authorChan, Ven_US
dc.contributor.authorLeung, NKen_US
dc.contributor.authorChan, TKen_US
dc.date.accessioned2012-09-05T05:13:45Z-
dc.date.available2012-09-05T05:13:45Z-
dc.date.issued1984en_US
dc.identifier.citationBritish Medical Journal, 1984, v. 289 n. 6450, p. 947-948en_US
dc.identifier.issn0959-8146en_US
dc.identifier.urihttp://hdl.handle.net/10722/161674-
dc.description.abstractThe prevalence of the BamH I site 3' to the β globin gene in Chinese people was determined in 123 normal subjects, 40 patients with heterozygous β thalassaemia, and 25 patients with homozygous β thalassaemia. The site was present in 71.1% and absent in 28.9% of the chromosomes carrying normal β genes. All 25 patients with β thalassaemia major had the site. This BamH I polymorphism may be used for prenatal diagnosis in about 29% of the pregnancies at risk.en_US
dc.languageengen_US
dc.relation.ispartofBritish Medical Journalen_US
dc.subject.meshAdulten_US
dc.subject.meshAsian Continental Ancestry Groupen_US
dc.subject.meshDna Restriction Enzymesen_US
dc.subject.meshDeoxyribonuclease Bamhien_US
dc.subject.meshFemaleen_US
dc.subject.meshGenesen_US
dc.subject.meshGenetic Linkageen_US
dc.subject.meshGlobins - Geneticsen_US
dc.subject.meshHong Kongen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshPolymorphism, Geneticen_US
dc.subject.meshPregnancyen_US
dc.subject.meshPrenatal Diagnosis - Methodsen_US
dc.subject.meshThalassemia - Diagnosis - Geneticsen_US
dc.titleBamH I polymorphism in the Chinese: Its potential usefulness in prenatal diagnosis of β thalassaemiaen_US
dc.typeArticleen_US
dc.identifier.emailChan, V:vnychana@hkucc.hku.hken_US
dc.identifier.authorityChan, V=rp00320en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1136/bmj.289.6450.947-
dc.identifier.pmid6091839-
dc.identifier.scopuseid_2-s2.0-0021219248en_US
dc.identifier.volume289en_US
dc.identifier.issue6450en_US
dc.identifier.spage947en_US
dc.identifier.epage948en_US
dc.identifier.isiWOS:A1984TM39100009-
dc.identifier.scopusauthoridChan, V=7202654865en_US
dc.identifier.scopusauthoridLeung, NK=36895263700en_US
dc.identifier.scopusauthoridChan, TK=7402687762en_US
dc.identifier.issnl0959-8146-

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