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Article: Antithrombin III and fibrinogen degradation product (fragment E) in diabetic nephropathy

TitleAntithrombin III and fibrinogen degradation product (fragment E) in diabetic nephropathy
Authors
Issue Date1982
PublisherB M J Publishing Group. The Journal's web site is located at http://jcp.bmjjournals.com/
Citation
Journal Of Clinical Pathology, 1982, v. 35 n. 6, p. 661-666 How to Cite?
AbstractPlasma antithrombin III (AtIII), serum fragment E (FgE) and urine AtIII and FgE were measured in 25 diabetic patients with proteinuria above 1 g per day and compared to that in 25 patients with non-diabetic nephropathy, matched for the degree of proteinuria. Plasma AtIII concentrations were normal in both groups but FgE concentrations were increased. The level of plasma AtIII was directly related to HbA1 concentrations in the diabetics. For the same degree of proteinuria, the diabetic patients lost more AtIII and FgE in the urine. Urine AtIII was found to be mostly bound to activated procoagulants. Both urine AtIII and urine FgE correlated inversely with creatinine clearance. It was concluded that intraglomerular thrombosis probably contributes to the deteriorating renal function in diabetic nephropathy and is reflected in the concentrations of urine AtIII and FgE.
Persistent Identifierhttp://hdl.handle.net/10722/161663
ISSN
2015 Impact Factor: 2.912
2015 SCImago Journal Rankings: 1.260
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorChan, Ven_US
dc.contributor.authorYeung, CKen_US
dc.contributor.authorChan, TKen_US
dc.date.accessioned2012-09-05T05:13:40Z-
dc.date.available2012-09-05T05:13:40Z-
dc.date.issued1982en_US
dc.identifier.citationJournal Of Clinical Pathology, 1982, v. 35 n. 6, p. 661-666en_US
dc.identifier.issn0021-9746en_US
dc.identifier.urihttp://hdl.handle.net/10722/161663-
dc.description.abstractPlasma antithrombin III (AtIII), serum fragment E (FgE) and urine AtIII and FgE were measured in 25 diabetic patients with proteinuria above 1 g per day and compared to that in 25 patients with non-diabetic nephropathy, matched for the degree of proteinuria. Plasma AtIII concentrations were normal in both groups but FgE concentrations were increased. The level of plasma AtIII was directly related to HbA1 concentrations in the diabetics. For the same degree of proteinuria, the diabetic patients lost more AtIII and FgE in the urine. Urine AtIII was found to be mostly bound to activated procoagulants. Both urine AtIII and urine FgE correlated inversely with creatinine clearance. It was concluded that intraglomerular thrombosis probably contributes to the deteriorating renal function in diabetic nephropathy and is reflected in the concentrations of urine AtIII and FgE.en_US
dc.languageengen_US
dc.publisherB M J Publishing Group. The Journal's web site is located at http://jcp.bmjjournals.com/en_US
dc.relation.ispartofJournal of Clinical Pathologyen_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshAntithrombin Iii - Metabolism - Urineen_US
dc.subject.meshDiabetic Nephropathies - Blood - Metabolism - Urineen_US
dc.subject.meshFemaleen_US
dc.subject.meshFibrin Fibrinogen Degradation Products - Metabolism - Urineen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshProteinuria - Metabolismen_US
dc.subject.meshRadioimmunoassayen_US
dc.titleAntithrombin III and fibrinogen degradation product (fragment E) in diabetic nephropathyen_US
dc.typeArticleen_US
dc.identifier.emailChan, V:vnychana@hkucc.hku.hken_US
dc.identifier.authorityChan, V=rp00320en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1136/jcp.35.6.661-
dc.identifier.pmid7085916-
dc.identifier.scopuseid_2-s2.0-0019955030en_US
dc.identifier.volume35en_US
dc.identifier.issue6en_US
dc.identifier.spage661en_US
dc.identifier.epage666en_US
dc.identifier.isiWOS:A1982NU33300016-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridChan, V=7202654865en_US
dc.identifier.scopusauthoridYeung, CK=7201354123en_US
dc.identifier.scopusauthoridChan, TK=7402687762en_US

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