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Article: Antithrombin III, the major modulator of intravascular coagulation, is synthesized by human endothelial cells

TitleAntithrombin III, the major modulator of intravascular coagulation, is synthesized by human endothelial cells
Authors
Issue Date1981
PublisherSchattauer GmbH. The Journal's web site is located at http://www.thrombosis-online.com
Citation
Thrombosis And Haemostasis, 1981, v. 46 n. 2, p. 504-506 How to Cite?
AbstractHuman endothelial cells in culture is shown to synthesize antithrombin III (At-III). The endothelial cell At-III (EC-At-III) consists of a small fraction similar to plasma At-III and a larger fraction with decreased heparin-binding as tested by crossed immunoelectrophoresis. However, both the anti-Xa and thrombin-neutralizing activities of the EC-At-III were rapid and active even in the absence of added heparin. It is concluded that the major portion was probably bound to endogenous heparin-like substance, thus accounting for its decreased exogenous heparin binding. The presence of At-III and other antithrombotic factors in the vascular endothelium offer protection against thrombosis and possibly atherosclerosis.
Persistent Identifierhttp://hdl.handle.net/10722/161657
ISSN
2015 Impact Factor: 5.255
2015 SCImago Journal Rankings: 2.089
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorChan, TKen_US
dc.contributor.authorChan, Ven_US
dc.date.accessioned2012-09-05T05:13:35Z-
dc.date.available2012-09-05T05:13:35Z-
dc.date.issued1981en_US
dc.identifier.citationThrombosis And Haemostasis, 1981, v. 46 n. 2, p. 504-506en_US
dc.identifier.issn0340-6245en_US
dc.identifier.urihttp://hdl.handle.net/10722/161657-
dc.description.abstractHuman endothelial cells in culture is shown to synthesize antithrombin III (At-III). The endothelial cell At-III (EC-At-III) consists of a small fraction similar to plasma At-III and a larger fraction with decreased heparin-binding as tested by crossed immunoelectrophoresis. However, both the anti-Xa and thrombin-neutralizing activities of the EC-At-III were rapid and active even in the absence of added heparin. It is concluded that the major portion was probably bound to endogenous heparin-like substance, thus accounting for its decreased exogenous heparin binding. The presence of At-III and other antithrombotic factors in the vascular endothelium offer protection against thrombosis and possibly atherosclerosis.en_US
dc.languageengen_US
dc.publisherSchattauer GmbH. The Journal's web site is located at http://www.thrombosis-online.comen_US
dc.relation.ispartofThrombosis and Haemostasisen_US
dc.subject.meshAntithrombin Iii - Biosynthesis - Pharmacologyen_US
dc.subject.meshAutoradiographyen_US
dc.subject.meshBlood Vessels - Cytology - Metabolismen_US
dc.subject.meshCells, Cultureden_US
dc.subject.meshEndothelium - Metabolismen_US
dc.subject.meshFactor X - Antagonists & Inhibitorsen_US
dc.subject.meshFactor Xaen_US
dc.subject.meshHeparin - Pharmacologyen_US
dc.subject.meshHumansen_US
dc.subject.meshImmunoelectrophoresis, Two-Dimensionalen_US
dc.subject.meshNeutralization Testsen_US
dc.subject.meshThrombin - Antagonists & Inhibitorsen_US
dc.titleAntithrombin III, the major modulator of intravascular coagulation, is synthesized by human endothelial cellsen_US
dc.typeArticleen_US
dc.identifier.emailChan, V:vnychana@hkucc.hku.hken_US
dc.identifier.authorityChan, V=rp00320en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid7302889-
dc.identifier.scopuseid_2-s2.0-0019406050en_US
dc.identifier.volume46en_US
dc.identifier.issue2en_US
dc.identifier.spage504en_US
dc.identifier.epage506en_US
dc.identifier.isiWOS:A1981MG28700006-
dc.publisher.placeGermanyen_US
dc.identifier.scopusauthoridChan, TK=7402687762en_US
dc.identifier.scopusauthoridChan, V=7202654865en_US

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