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Article: Globin chain synthesis in haemoglobin New York (β113 valine α[ glutamic acid)

TitleGlobin chain synthesis in haemoglobin New York (β113 valine α[ glutamic acid)
Authors
Issue Date1980
PublisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/BJH
Citation
British Journal Of Haematology, 1980, v. 46 n. 4, p. 557-564 How to Cite?
AbstractThe presence of Hb New York was confirmed in a Chinese family in which affected members have occasional red cells with Hb H-like inclusions and a relative decrease in α chain synthesis, suggestive of a coexisting α thalasssaemia trait. However, globin gene mapping and DNA hybridization revealed no deletion of the α genome. Timed-incubation experiments showed that the rate of synthesis of β(NY) chain was greater than that of normal β chain in the early periods. Chromatographic separation of Hb NY and Hb A before chain analysis revealed preferential binding of newly synthesized α chains to β(NY), with a four-fold increase in specific activity of the α(Hb NY) chains. It is concluded that β(NY) chain is being synthesized more rapidly and its increased turnover may account for this presentation of apparent α chain deficiency.
Persistent Identifierhttp://hdl.handle.net/10722/161654
ISSN
2015 Impact Factor: 5.401
2015 SCImago Journal Rankings: 2.313
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorTodd, Den_US
dc.contributor.authorChan, Ven_US
dc.contributor.authorSchneider, RGen_US
dc.date.accessioned2012-09-05T05:13:35Z-
dc.date.available2012-09-05T05:13:35Z-
dc.date.issued1980en_US
dc.identifier.citationBritish Journal Of Haematology, 1980, v. 46 n. 4, p. 557-564en_US
dc.identifier.issn0007-1048en_US
dc.identifier.urihttp://hdl.handle.net/10722/161654-
dc.description.abstractThe presence of Hb New York was confirmed in a Chinese family in which affected members have occasional red cells with Hb H-like inclusions and a relative decrease in α chain synthesis, suggestive of a coexisting α thalasssaemia trait. However, globin gene mapping and DNA hybridization revealed no deletion of the α genome. Timed-incubation experiments showed that the rate of synthesis of β(NY) chain was greater than that of normal β chain in the early periods. Chromatographic separation of Hb NY and Hb A before chain analysis revealed preferential binding of newly synthesized α chains to β(NY), with a four-fold increase in specific activity of the α(Hb NY) chains. It is concluded that β(NY) chain is being synthesized more rapidly and its increased turnover may account for this presentation of apparent α chain deficiency.en_US
dc.languageengen_US
dc.publisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/BJHen_US
dc.relation.ispartofBritish Journal of Haematologyen_US
dc.subject.meshAdulten_US
dc.subject.meshBlood Protein Electrophoresisen_US
dc.subject.meshChemical Phenomenaen_US
dc.subject.meshChemistryen_US
dc.subject.meshChina - Ethnologyen_US
dc.subject.meshChromatography, Ion Exchangeen_US
dc.subject.meshErythrocytes - Metabolismen_US
dc.subject.meshGlobins - Biosynthesisen_US
dc.subject.meshGlutamatesen_US
dc.subject.meshHemoglobins, Abnormal - Biosynthesis - Geneticsen_US
dc.subject.meshHong Kongen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshPedigreeen_US
dc.subject.meshReticulocytes - Metabolismen_US
dc.titleGlobin chain synthesis in haemoglobin New York (β113 valine α[ glutamic acid)en_US
dc.typeArticleen_US
dc.identifier.emailChan, V:vnychana@hkucc.hku.hken_US
dc.identifier.authorityChan, V=rp00320en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1111/j.1365-2141.1980.tb06012.x-
dc.identifier.pmid7437334-
dc.identifier.scopuseid_2-s2.0-0019185599en_US
dc.identifier.volume46en_US
dc.identifier.issue4en_US
dc.identifier.spage557en_US
dc.identifier.epage564en_US
dc.identifier.isiWOS:A1980KS39700006-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridTodd, D=7201388182en_US
dc.identifier.scopusauthoridChan, V=7202654865en_US
dc.identifier.scopusauthoridSchneider, RG=7403513859en_US

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