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Article: Deep vein thrombosis and changes in coagulation and fibrinolysis after gynaecological operations in Chinese: The effect of oral contraceptives and malignant disease

TitleDeep vein thrombosis and changes in coagulation and fibrinolysis after gynaecological operations in Chinese: The effect of oral contraceptives and malignant disease
Authors
Issue Date1980
PublisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/BJH
Citation
British Journal Of Haematology, 1980, v. 46 n. 4, p. 603-612 How to Cite?
AbstractOf 154 Chinese patients who underwent gynaecological operations, four showed a positive 125I fibrinogen leg scan for venous thrombosis, an overall incidence of 2.6%. In those who were on oral contraceptives and had major pelvic surgery for benign conditions, the incidence was 10.5%; in those who had Wertheim hysterectomy for carcinoma of cervix, it was 6.7%. This confirms the rarity of post-operative thromboembolism in the Chinese. Fragment E showed a biphasic rise after major operation due to tisue injury and venous thrombosis. In patients with malignancy, the postoperative 'fibrinolytic shutdown', represented by decreased plasminogen activator together with increased α 1 antitrypsin and C - 1 inhibitor levels, was more marked. In addition, α 2 macroglobulin level was lower and fell significantly after operation. In patients on oral contraceptives, fragment E levels were higher after surgery and there was no decrease in plasminogen activator levels. Antithrombin III levels did not fall except in three of the four patients with venous thrombosis. A marked increase in fragment E level and a decrease in antithrombin III level might be useful diagnostic markers for postoperative venous thrombosis. | Of 154 Chinese patients who underwent gynecological operations, 4 showed a positive fibrinogen leg scan for venous thrombosis, an overall incidence of 2.6%. In those who were on (OC) oral contraceptives and had major pelvic surgery for benign conditions, the incidence was 10.5%; in those who had Wertheim hysterectomy for carcinoma for cervix, it was 6.7%. This confirms the rarity of postoperative thromboembolism in the Chinese. Fragment E showed a biphasic rise after major operation due to tissue injury and venous thrombosis. In patients with malignancy, the postoperative fibrinolytic shutdown, represented by decreased plasminogen activator together with increased alpha 1 antitrypsin and C inhibitor levels, was more marked. In addition alpha 2 macroglobulin level was lower and fell significantly after operation. In patients on OCs, fragment E levels were higher after surgery and there was no decrease in plasminogen activator levels. Antithrombin 3 levels did not fall except in 3 of the 4 patients with venous thrombosis. A marked increase in fragment E level and a decrease in antithrombin 3 level might be useful diagnostic markers for postoperative venous thrombosis.
Persistent Identifierhttp://hdl.handle.net/10722/161652
ISSN
2015 Impact Factor: 5.401
2015 SCImago Journal Rankings: 2.313
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorTso, SCen_US
dc.contributor.authorWong, Ven_US
dc.contributor.authorChan, Ven_US
dc.date.accessioned2012-09-05T05:13:34Z-
dc.date.available2012-09-05T05:13:34Z-
dc.date.issued1980en_US
dc.identifier.citationBritish Journal Of Haematology, 1980, v. 46 n. 4, p. 603-612en_US
dc.identifier.issn0007-1048en_US
dc.identifier.urihttp://hdl.handle.net/10722/161652-
dc.description.abstractOf 154 Chinese patients who underwent gynaecological operations, four showed a positive 125I fibrinogen leg scan for venous thrombosis, an overall incidence of 2.6%. In those who were on oral contraceptives and had major pelvic surgery for benign conditions, the incidence was 10.5%; in those who had Wertheim hysterectomy for carcinoma of cervix, it was 6.7%. This confirms the rarity of post-operative thromboembolism in the Chinese. Fragment E showed a biphasic rise after major operation due to tisue injury and venous thrombosis. In patients with malignancy, the postoperative 'fibrinolytic shutdown', represented by decreased plasminogen activator together with increased α 1 antitrypsin and C - 1 inhibitor levels, was more marked. In addition, α 2 macroglobulin level was lower and fell significantly after operation. In patients on oral contraceptives, fragment E levels were higher after surgery and there was no decrease in plasminogen activator levels. Antithrombin III levels did not fall except in three of the four patients with venous thrombosis. A marked increase in fragment E level and a decrease in antithrombin III level might be useful diagnostic markers for postoperative venous thrombosis. | Of 154 Chinese patients who underwent gynecological operations, 4 showed a positive fibrinogen leg scan for venous thrombosis, an overall incidence of 2.6%. In those who were on (OC) oral contraceptives and had major pelvic surgery for benign conditions, the incidence was 10.5%; in those who had Wertheim hysterectomy for carcinoma for cervix, it was 6.7%. This confirms the rarity of postoperative thromboembolism in the Chinese. Fragment E showed a biphasic rise after major operation due to tissue injury and venous thrombosis. In patients with malignancy, the postoperative fibrinolytic shutdown, represented by decreased plasminogen activator together with increased alpha 1 antitrypsin and C inhibitor levels, was more marked. In addition alpha 2 macroglobulin level was lower and fell significantly after operation. In patients on OCs, fragment E levels were higher after surgery and there was no decrease in plasminogen activator levels. Antithrombin 3 levels did not fall except in 3 of the 4 patients with venous thrombosis. A marked increase in fragment E level and a decrease in antithrombin 3 level might be useful diagnostic markers for postoperative venous thrombosis.en_US
dc.languageengen_US
dc.publisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/BJHen_US
dc.relation.ispartofBritish Journal of Haematologyen_US
dc.subject.meshAsian Continental Ancestry Groupen_US
dc.subject.meshBlood Coagulationen_US
dc.subject.meshChina - Ethnologyen_US
dc.subject.meshContraceptives, Oral - Adverse Effectsen_US
dc.subject.meshFemaleen_US
dc.subject.meshFibrinolysisen_US
dc.subject.meshGenital Diseases, Female - Surgeryen_US
dc.subject.meshHong Kongen_US
dc.subject.meshHumansen_US
dc.subject.meshPostoperative Complicationsen_US
dc.subject.meshPostoperative Perioden_US
dc.subject.meshThrombophlebitis - Etiologyen_US
dc.subject.meshUterine Cervical Neoplasms - Complicationsen_US
dc.titleDeep vein thrombosis and changes in coagulation and fibrinolysis after gynaecological operations in Chinese: The effect of oral contraceptives and malignant diseaseen_US
dc.typeArticleen_US
dc.identifier.emailChan, V:vnychana@hkucc.hku.hken_US
dc.identifier.authorityChan, V=rp00320en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1111/j.1365-2141.1980.tb06018.x-
dc.identifier.pmid7437338-
dc.identifier.scopuseid_2-s2.0-0019142296en_US
dc.identifier.volume46en_US
dc.identifier.issue4en_US
dc.identifier.spage603en_US
dc.identifier.epage612en_US
dc.identifier.isiWOS:A1980KS39700012-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridTso, SC=7103261600en_US
dc.identifier.scopusauthoridWong, V=24381178900en_US
dc.identifier.scopusauthoridChan, V=7202654865en_US

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