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Article: The determination of antithrombin III by radioimmunoassay and its clinical application

TitleThe determination of antithrombin III by radioimmunoassay and its clinical application
Authors
Issue Date1979
PublisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/BJH
Citation
British Journal Of Haematology, 1979, v. 41 n. 4, p. 563-572 How to Cite?
AbstractA radioimmunoassay (RIA) had been developed for the determination of antithrombin III (AT III) in man. The detection limit was 25 μg/dl. AT III-RIA level and biological activity (anti-Xa) were significantly correlated (r=0.737, P<0.001). Plasma levels in 36 healthy males (mean ± SD, and in mg/dl) and 21 healthy females (19.1±2.4 mg/dl) were similar. Serial AT III measurements in normal menstruating females showed lower levels during midcycle and higher concentrations during menstruation. In carcinomas, the AT III levels were lower than normal, particularly in hepatocellular carcinoma. In cirrhosis of liver, the levels were markedly decreased in some patients were below that found in congenital AT III deficiency. Patients with deep vein thrombosis and patients with heart valve replacement had lower levels than normal, while patients with cerebral vascular occlusion had normal levels. The possible use of AT III as a diagnostic tool of post-operative deep vein thrombosis was demonstrated in one patient after hysterectomy. The increased sensitivity, specificity and precision of this type of assay offer distinct advantages over existing methods of AT III estimation.
Persistent Identifierhttp://hdl.handle.net/10722/161650
ISSN
2015 Impact Factor: 5.401
2015 SCImago Journal Rankings: 2.313
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorChan, Ven_US
dc.contributor.authorChan, TKen_US
dc.contributor.authorWong, Ven_US
dc.date.accessioned2012-09-05T05:13:31Z-
dc.date.available2012-09-05T05:13:31Z-
dc.date.issued1979en_US
dc.identifier.citationBritish Journal Of Haematology, 1979, v. 41 n. 4, p. 563-572en_US
dc.identifier.issn0007-1048en_US
dc.identifier.urihttp://hdl.handle.net/10722/161650-
dc.description.abstractA radioimmunoassay (RIA) had been developed for the determination of antithrombin III (AT III) in man. The detection limit was 25 μg/dl. AT III-RIA level and biological activity (anti-Xa) were significantly correlated (r=0.737, P<0.001). Plasma levels in 36 healthy males (mean ± SD, and in mg/dl) and 21 healthy females (19.1±2.4 mg/dl) were similar. Serial AT III measurements in normal menstruating females showed lower levels during midcycle and higher concentrations during menstruation. In carcinomas, the AT III levels were lower than normal, particularly in hepatocellular carcinoma. In cirrhosis of liver, the levels were markedly decreased in some patients were below that found in congenital AT III deficiency. Patients with deep vein thrombosis and patients with heart valve replacement had lower levels than normal, while patients with cerebral vascular occlusion had normal levels. The possible use of AT III as a diagnostic tool of post-operative deep vein thrombosis was demonstrated in one patient after hysterectomy. The increased sensitivity, specificity and precision of this type of assay offer distinct advantages over existing methods of AT III estimation.en_US
dc.languageengen_US
dc.publisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/BJHen_US
dc.relation.ispartofBritish Journal of Haematologyen_US
dc.subject.meshAdulten_US
dc.subject.meshAntithrombin Iii - Analysis - Immunology - Physiologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshLiver Cirrhosis - Blooden_US
dc.subject.meshMaleen_US
dc.subject.meshMenstruationen_US
dc.subject.meshNeoplasms - Blooden_US
dc.subject.meshPostoperative Complications - Blood - Diagnosisen_US
dc.subject.meshRadioimmunoassayen_US
dc.subject.meshThrombophlebitis - Blood - Diagnosisen_US
dc.titleThe determination of antithrombin III by radioimmunoassay and its clinical applicationen_US
dc.typeArticleen_US
dc.identifier.emailChan, V:vnychana@hkucc.hku.hken_US
dc.identifier.authorityChan, V=rp00320en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1111/j.1365-2141.1979.tb05893.x-
dc.identifier.pmid435403-
dc.identifier.scopuseid_2-s2.0-0018768560en_US
dc.identifier.volume41en_US
dc.identifier.issue4en_US
dc.identifier.spage563en_US
dc.identifier.epage572en_US
dc.identifier.isiWOS:A1979GP10000011-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridChan, V=7202654865en_US
dc.identifier.scopusauthoridChan, TK=7402687762en_US
dc.identifier.scopusauthoridWong, V=24381178900en_US

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