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Article: The effect of heroin addiction on pituitary-testicular function

TitleThe effect of heroin addiction on pituitary-testicular function
Authors
Issue Date1978
PublisherWiley-Blackwell Publishing Ltd.. The Journal's web site is located at http://www.wiley.com/bw/journal.asp?ref=0300-0664
Citation
Clinical Endocrinology, 1978, v. 9 n. 5, p. 455-461 How to Cite?
AbstractThe effect of heroin addiction on pituitary-testicular function was studied in 54 active and 19 abstinent addicts and their results were compared with those of 43 age-matched controls. Abnormal sexual function was frequently found in heroin addicts and this persisted after drug withdrawal. The mean total (mean ± SE, 18.1 ± 1.0 nmol/l) and free (0.17 ± 0.03 nmol/l) testosterone (T) levels in heroin addicts were significantly lower than those in healthy controls (total T 22.8 ± 1.1 nmol/l, P<0.005; free T 0.30 ± 0.03 nmol/l, P<0.005). The mean sex hormone binding globulin binding capacity was higher in heroin addicts (60.1 ± 5.2 nM) than in healthy controls (35.5 ± 2.1 nM). These hormonal changes returned promptly to normal after withdrawal. The basal LH and FSH and the responses to LHRH were comparable in the 3 groups studied. The finding of significantly lower total and free T together with higher SHBG indicates an abnormal testicular function in heroin addiction. Normal basal and LHRH-stimulated LH and FSH levels suggest that chronic heroin abuse depressed testicular function via the hypothalamus or higher centers.
Persistent Identifierhttp://hdl.handle.net/10722/161636
ISSN
2015 Impact Factor: 3.487
2015 SCImago Journal Rankings: 1.314
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorWang, Cen_US
dc.contributor.authorChan, Ven_US
dc.contributor.authorYeung, RTTen_US
dc.date.accessioned2012-09-05T05:13:24Z-
dc.date.available2012-09-05T05:13:24Z-
dc.date.issued1978en_US
dc.identifier.citationClinical Endocrinology, 1978, v. 9 n. 5, p. 455-461en_US
dc.identifier.issn0300-0664en_US
dc.identifier.urihttp://hdl.handle.net/10722/161636-
dc.description.abstractThe effect of heroin addiction on pituitary-testicular function was studied in 54 active and 19 abstinent addicts and their results were compared with those of 43 age-matched controls. Abnormal sexual function was frequently found in heroin addicts and this persisted after drug withdrawal. The mean total (mean ± SE, 18.1 ± 1.0 nmol/l) and free (0.17 ± 0.03 nmol/l) testosterone (T) levels in heroin addicts were significantly lower than those in healthy controls (total T 22.8 ± 1.1 nmol/l, P<0.005; free T 0.30 ± 0.03 nmol/l, P<0.005). The mean sex hormone binding globulin binding capacity was higher in heroin addicts (60.1 ± 5.2 nM) than in healthy controls (35.5 ± 2.1 nM). These hormonal changes returned promptly to normal after withdrawal. The basal LH and FSH and the responses to LHRH were comparable in the 3 groups studied. The finding of significantly lower total and free T together with higher SHBG indicates an abnormal testicular function in heroin addiction. Normal basal and LHRH-stimulated LH and FSH levels suggest that chronic heroin abuse depressed testicular function via the hypothalamus or higher centers.en_US
dc.languageengen_US
dc.publisherWiley-Blackwell Publishing Ltd.. The Journal's web site is located at http://www.wiley.com/bw/journal.asp?ref=0300-0664en_US
dc.relation.ispartofClinical Endocrinologyen_US
dc.subject.meshAdulten_US
dc.subject.meshFollicle Stimulating Hormone - Secretionen_US
dc.subject.meshHeroin Dependence - Physiopathologyen_US
dc.subject.meshHumansen_US
dc.subject.meshLuteinizing Hormone - Secretionen_US
dc.subject.meshMaleen_US
dc.subject.meshPituitary Gland - Drug Effects - Physiopathologyen_US
dc.subject.meshSex Hormone-Binding Globulin - Analysisen_US
dc.subject.meshSexual Behavior - Drug Effectsen_US
dc.subject.meshTestis - Drug Effects - Physiopathologyen_US
dc.subject.meshTestosterone - Blooden_US
dc.titleThe effect of heroin addiction on pituitary-testicular functionen_US
dc.typeArticleen_US
dc.identifier.emailChan, V:vnychana@hkucc.hku.hken_US
dc.identifier.authorityChan, V=rp00320en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1111/j.1365-2265.1978.tb03585.x-
dc.identifier.pmid569031-
dc.identifier.scopuseid_2-s2.0-0018166937en_US
dc.identifier.volume9en_US
dc.identifier.issue5en_US
dc.identifier.spage455en_US
dc.identifier.epage461en_US
dc.identifier.isiWOS:A1978FX15500008-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridWang, C=7501631357en_US
dc.identifier.scopusauthoridChan, V=7202654865en_US
dc.identifier.scopusauthoridYeung, RTT=7102833337en_US

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