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Article: Effect of surgical stress on pituitary-testicular function

TitleEffect of surgical stress on pituitary-testicular function
Authors
Issue Date1978
PublisherWiley-Blackwell Publishing Ltd.. The Journal's web site is located at http://www.wiley.com/bw/journal.asp?ref=0300-0664
Citation
Clinical Endocrinology, 1978, v. 9 n. 3, p. 255-266 How to Cite?
AbstractThe effect of surgical stress on the secretions of LH, FSH, testosterone (T) and oestradiol (E2) were studied in twelve male patients. During surgery LH rose significantly; post-operatively, LH fell but remained persistently elevated a week after operation. However, T and E2 fell progressively to a nadir on the second and fifth post-operative day respectively and remained suppressed. Serum FSH showed no significant change. Despite a post-operative decrease in sex hormone binding globulin (SHBG) binding capacity, non-SHBG bound T showed a decrease parallel to T. Multiple sampling studies showed that the secretions of LH were increased and that of T were decreased post-operatively. Following surgery, LH responses to LHRH were magnified, FSH and T responses showed no significant change when compared with the pre-operative responses. These data suggest that secretions of LH were increased during surgery. Following surgical stress, T and E2 concentrations were suppressed resulting in a compensatory elevation of LH concentrations.
Persistent Identifierhttp://hdl.handle.net/10722/161632
ISSN
2015 Impact Factor: 3.487
2015 SCImago Journal Rankings: 1.314
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorWang, Cen_US
dc.contributor.authorChan, Ven_US
dc.contributor.authorYeung, RTTen_US
dc.date.accessioned2012-09-05T05:13:22Z-
dc.date.available2012-09-05T05:13:22Z-
dc.date.issued1978en_US
dc.identifier.citationClinical Endocrinology, 1978, v. 9 n. 3, p. 255-266en_US
dc.identifier.issn0300-0664en_US
dc.identifier.urihttp://hdl.handle.net/10722/161632-
dc.description.abstractThe effect of surgical stress on the secretions of LH, FSH, testosterone (T) and oestradiol (E2) were studied in twelve male patients. During surgery LH rose significantly; post-operatively, LH fell but remained persistently elevated a week after operation. However, T and E2 fell progressively to a nadir on the second and fifth post-operative day respectively and remained suppressed. Serum FSH showed no significant change. Despite a post-operative decrease in sex hormone binding globulin (SHBG) binding capacity, non-SHBG bound T showed a decrease parallel to T. Multiple sampling studies showed that the secretions of LH were increased and that of T were decreased post-operatively. Following surgery, LH responses to LHRH were magnified, FSH and T responses showed no significant change when compared with the pre-operative responses. These data suggest that secretions of LH were increased during surgery. Following surgical stress, T and E2 concentrations were suppressed resulting in a compensatory elevation of LH concentrations.en_US
dc.languageengen_US
dc.publisherWiley-Blackwell Publishing Ltd.. The Journal's web site is located at http://www.wiley.com/bw/journal.asp?ref=0300-0664en_US
dc.relation.ispartofClinical Endocrinologyen_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshEstradiol - Blood - Secretionen_US
dc.subject.meshFollicle Stimulating Hormone - Blood - Secretionen_US
dc.subject.meshGonadotropin-Releasing Hormone - Diagnostic Useen_US
dc.subject.meshHumansen_US
dc.subject.meshLuteinizing Hormone - Blood - Secretionen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshPituitary Gland - Physiopathologyen_US
dc.subject.meshSex Hormone-Binding Globulin - Analysisen_US
dc.subject.meshStress, Physiological - Physiopathologyen_US
dc.subject.meshSurgical Procedures, Operativeen_US
dc.subject.meshTestis - Physiopathologyen_US
dc.subject.meshTestosterone - Blood - Secretionen_US
dc.titleEffect of surgical stress on pituitary-testicular functionen_US
dc.typeArticleen_US
dc.identifier.emailChan, V:vnychana@hkucc.hku.hken_US
dc.identifier.authorityChan, V=rp00320en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1111/j.1365-2265.1978.tb02208.x-
dc.identifier.pmid361300-
dc.identifier.scopuseid_2-s2.0-0018092107en_US
dc.identifier.volume9en_US
dc.identifier.issue3en_US
dc.identifier.spage255en_US
dc.identifier.epage266en_US
dc.identifier.isiWOS:A1978FR19800009-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridWang, C=7501631357en_US
dc.identifier.scopusauthoridChan, V=7202654865en_US
dc.identifier.scopusauthoridYeung, RTT=7102833337en_US

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