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Article: Transfer of digoxin across the placenta and into breast milk

TitleTransfer of digoxin across the placenta and into breast milk
Authors
Issue Date1978
PublisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/BJOG
Citation
British Journal Of Obstetrics And Gynaecology, 1978, v. 85 n. 8, p. 605-609 How to Cite?
AbstractEleven mothers given digoxin throughout pregnancy because of rheumatic heart disease were studied. Digoxin was identified in the placenta and, for the first time, in milk. Paired cord and maternal blood samples obtained at parturition showed lower digoxin levels in cord blood than in maternal blood. The total tissue-bound digoxin level in the placenta correlated closely with maternal digoxin levels. These findings suggest strongly the presence of a placental barrier for digoxin. Similar digoxin concentrations (0.25±0.015 nmol/l) were found in milk samples obtained daily between the third and seventh days post partum. The half-life of digoxin in the newborn 36.2±5.43 hr (Mean±SEM); thus all the digoxin present at birth would be excreted within 10 to 11 days.
Persistent Identifierhttp://hdl.handle.net/10722/161631
ISSN
2001 Impact Factor: 2.321
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorChan, Ven_US
dc.contributor.authorTse, TFen_US
dc.contributor.authorWong, Ven_US
dc.date.accessioned2012-09-05T05:13:22Z-
dc.date.available2012-09-05T05:13:22Z-
dc.date.issued1978en_US
dc.identifier.citationBritish Journal Of Obstetrics And Gynaecology, 1978, v. 85 n. 8, p. 605-609en_US
dc.identifier.issn0306-5456en_US
dc.identifier.urihttp://hdl.handle.net/10722/161631-
dc.description.abstractEleven mothers given digoxin throughout pregnancy because of rheumatic heart disease were studied. Digoxin was identified in the placenta and, for the first time, in milk. Paired cord and maternal blood samples obtained at parturition showed lower digoxin levels in cord blood than in maternal blood. The total tissue-bound digoxin level in the placenta correlated closely with maternal digoxin levels. These findings suggest strongly the presence of a placental barrier for digoxin. Similar digoxin concentrations (0.25±0.015 nmol/l) were found in milk samples obtained daily between the third and seventh days post partum. The half-life of digoxin in the newborn 36.2±5.43 hr (Mean±SEM); thus all the digoxin present at birth would be excreted within 10 to 11 days.en_US
dc.languageengen_US
dc.publisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/BJOGen_US
dc.relation.ispartofBritish Journal of Obstetrics and Gynaecologyen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshDigoxin - Analysis - Blood - Metabolismen_US
dc.subject.meshFemaleen_US
dc.subject.meshFetal Blood - Analysisen_US
dc.subject.meshHalf-Lifeen_US
dc.subject.meshHumansen_US
dc.subject.meshInfant, Newbornen_US
dc.subject.meshMaternal-Fetal Exchangeen_US
dc.subject.meshMilk, Human - Analysisen_US
dc.subject.meshPlacenta - Analysisen_US
dc.subject.meshPregnancyen_US
dc.titleTransfer of digoxin across the placenta and into breast milken_US
dc.typeArticleen_US
dc.identifier.emailChan, V:vnychana@hkucc.hku.hken_US
dc.identifier.authorityChan, V=rp00320en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1111/j.1471-0528.1978.tb14929.x-
dc.identifier.pmid687540-
dc.identifier.scopuseid_2-s2.0-0017842558en_US
dc.identifier.volume85en_US
dc.identifier.issue8en_US
dc.identifier.spage605en_US
dc.identifier.epage609en_US
dc.identifier.isiWOS:A1978FM88700010-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridChan, V=7202654865en_US
dc.identifier.scopusauthoridTse, TF=7005496977en_US
dc.identifier.scopusauthoridWong, V=24381178900en_US

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