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Article: Clinical characteristics, treatment, and outcome of adult onset Still's disease in southern Chinese

TitleClinical characteristics, treatment, and outcome of adult onset Still's disease in southern Chinese
Authors
Issue Date1998
PublisherJournal of Rheumatology Publishing Co Ltd. The Journal's web site is located at http://www.jrheum.com
Citation
Journal Of Rheumatology, 1998, v. 25 n. 12, p. 2345-2351 How to Cite?
AbstractObjective. To study the clinical characteristics, treatment outcome, and complications of patients with adult onset Still's disease (AOSD) in our local Chinese population. Methods. Patients with AOSD were identified among others who attended our rheumatology clinics from 1967 to 1997 and were followed. Their clinical and laboratory features at presentation, treatment, and outcome were recorded and compared with other reported series. Results. Sixteen patients with AOSD were identified. Eleven (69%) were female. Nine (56%) had onset of the disease between 16 and 35 years of age. The commonest presenting features were fever (100%), arthritis (94%), rash (85%), weight loss (69%), and sore throat (63%). Fifteen patients presented with pyrexia of unknown origin and the median duration of fever before the establishment of the diagnosis was 6 weeks (range 4-75). The acute phase response was marked in all patients with gross elevation of erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), and complement levels. Hyperferritinemia (> 5 times normal) was present in 90% of cases. Most patients (81%) required corticosteroid therapy and 85% of those steroid treated patients received additional disease modifying agents. The mean duration of followup of our patients was 93.3 months (range 8-362). Five (33%) had monocyclic systemic disease, 6 (40%) had polycyclic systemic disease, and 4 (27%) had frequent relapses that progressed to a chronic arthropathy. Conclusion. AOSD in southern Chinese tends to run a benign course, with few patients evolving into chronic inflammatory arthropathy. A significantly lower incidence of serositis, lung involvement, and enlargement of the reticuloendothelial organs was observed at presentation compared with patients of different ethnic origins.
Persistent Identifierhttp://hdl.handle.net/10722/161625
ISSN
2015 Impact Factor: 3.236
2015 SCImago Journal Rankings: 1.225
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorMok, CCen_US
dc.contributor.authorLau, CSen_US
dc.contributor.authorWong, RWSen_US
dc.date.accessioned2012-09-05T05:13:13Z-
dc.date.available2012-09-05T05:13:13Z-
dc.date.issued1998en_US
dc.identifier.citationJournal Of Rheumatology, 1998, v. 25 n. 12, p. 2345-2351en_US
dc.identifier.issn0315-162Xen_US
dc.identifier.urihttp://hdl.handle.net/10722/161625-
dc.description.abstractObjective. To study the clinical characteristics, treatment outcome, and complications of patients with adult onset Still's disease (AOSD) in our local Chinese population. Methods. Patients with AOSD were identified among others who attended our rheumatology clinics from 1967 to 1997 and were followed. Their clinical and laboratory features at presentation, treatment, and outcome were recorded and compared with other reported series. Results. Sixteen patients with AOSD were identified. Eleven (69%) were female. Nine (56%) had onset of the disease between 16 and 35 years of age. The commonest presenting features were fever (100%), arthritis (94%), rash (85%), weight loss (69%), and sore throat (63%). Fifteen patients presented with pyrexia of unknown origin and the median duration of fever before the establishment of the diagnosis was 6 weeks (range 4-75). The acute phase response was marked in all patients with gross elevation of erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), and complement levels. Hyperferritinemia (> 5 times normal) was present in 90% of cases. Most patients (81%) required corticosteroid therapy and 85% of those steroid treated patients received additional disease modifying agents. The mean duration of followup of our patients was 93.3 months (range 8-362). Five (33%) had monocyclic systemic disease, 6 (40%) had polycyclic systemic disease, and 4 (27%) had frequent relapses that progressed to a chronic arthropathy. Conclusion. AOSD in southern Chinese tends to run a benign course, with few patients evolving into chronic inflammatory arthropathy. A significantly lower incidence of serositis, lung involvement, and enlargement of the reticuloendothelial organs was observed at presentation compared with patients of different ethnic origins.en_US
dc.languageengen_US
dc.publisherJournal of Rheumatology Publishing Co Ltd. The Journal's web site is located at http://www.jrheum.comen_US
dc.relation.ispartofJournal of Rheumatologyen_US
dc.subject.meshAcute-Phase Reaction - Complications - Immunologyen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshAnti-Inflammatory Agents, Non-Steroidal - Adverse Effects - Therapeutic Useen_US
dc.subject.meshAntirheumatic Agents - Adverse Effects - Therapeutic Useen_US
dc.subject.meshChina - Ethnologyen_US
dc.subject.meshCushing Syndrome - Chemically Induceden_US
dc.subject.meshFemaleen_US
dc.subject.meshFollow-Up Studiesen_US
dc.subject.meshGastrointestinal Hemorrhage - Chemically Induceden_US
dc.subject.meshHematologic Diseases - Complicationsen_US
dc.subject.meshHong Kong - Epidemiologyen_US
dc.subject.meshHumansen_US
dc.subject.meshHypertension - Chemically Induceden_US
dc.subject.meshHypertrophyen_US
dc.subject.meshJoint Diseases - Complicationsen_US
dc.subject.meshLiver Diseases - Complicationsen_US
dc.subject.meshLiver Function Testsen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshMononuclear Phagocyte System - Pathologyen_US
dc.subject.meshPharyngitis - Complicationsen_US
dc.subject.meshSkin Diseases - Complicationsen_US
dc.subject.meshSteroids - Adverse Effects - Therapeutic Useen_US
dc.subject.meshStill's Disease, Adult-Onset - Complications - Drug Therapy - Epidemiologyen_US
dc.subject.meshTreatment Outcomeen_US
dc.titleClinical characteristics, treatment, and outcome of adult onset Still's disease in southern Chineseen_US
dc.typeArticleen_US
dc.identifier.emailLau, CS:cslau@hku.hken_US
dc.identifier.authorityLau, CS=rp01348en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid9858428-
dc.identifier.scopuseid_2-s2.0-0009638450en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0009638450&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume25en_US
dc.identifier.issue12en_US
dc.identifier.spage2345en_US
dc.identifier.epage2351en_US
dc.identifier.isiWOS:000077280600010-
dc.publisher.placeCanadaen_US
dc.identifier.scopusauthoridMok, CC=7102344226en_US
dc.identifier.scopusauthoridLau, CS=14035682100en_US
dc.identifier.scopusauthoridWong, RWS=34875928200en_US

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