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Article: Autologous neural stem cell transplantation: A new treatment option for Parkinson's disease?

TitleAutologous neural stem cell transplantation: A new treatment option for Parkinson's disease?
Authors
Issue Date2009
PublisherChurchill Livingstone. The Journal's web site is located at http://www.elsevier.com/locate/mehy
Citation
Medical hypotheses, 2009, v. 73 n. 5, p. 757-759 How to Cite?
AbstractThe clinical motor dysfunction in Parkinson s disease (PD) is primarily linked to the depletion of dopamine in the striatum consecutive to the loss of the large dopaminergic neurons in the substantia nigra. Despite intense investigations, no effective therapy is available to prevent the onset, or to halt the progression of the neuronal cell loss. Here, we hypothesize that autologous adult neural stem cells (NSCs) are an attractive source for cell therapy to treat PD. They overcome the ethical issues inherent to the use of human fetal tissue or embryonic stem cells. NSCs derived from adult tissue also open the possibility for autologous transplantation, where NSCs are taken out from the patient, expanded and differentiated in vitro and re-implanted back as dopaminergic precursor cells.
Persistent Identifierhttp://hdl.handle.net/10722/161611
ISSN
2015 Impact Factor: 1.136
2015 SCImago Journal Rankings: 0.464
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorArias-Carrion, O-
dc.contributor.authorYuan, TF-
dc.date.accessioned2012-09-04T01:59:05Z-
dc.date.available2012-09-04T01:59:05Z-
dc.date.issued2009-
dc.identifier.citationMedical hypotheses, 2009, v. 73 n. 5, p. 757-759-
dc.identifier.issn0306-9877-
dc.identifier.urihttp://hdl.handle.net/10722/161611-
dc.description.abstractThe clinical motor dysfunction in Parkinson s disease (PD) is primarily linked to the depletion of dopamine in the striatum consecutive to the loss of the large dopaminergic neurons in the substantia nigra. Despite intense investigations, no effective therapy is available to prevent the onset, or to halt the progression of the neuronal cell loss. Here, we hypothesize that autologous adult neural stem cells (NSCs) are an attractive source for cell therapy to treat PD. They overcome the ethical issues inherent to the use of human fetal tissue or embryonic stem cells. NSCs derived from adult tissue also open the possibility for autologous transplantation, where NSCs are taken out from the patient, expanded and differentiated in vitro and re-implanted back as dopaminergic precursor cells.-
dc.languageeng-
dc.publisherChurchill Livingstone. The Journal's web site is located at http://www.elsevier.com/locate/mehy-
dc.relation.ispartofMedical hypotheses-
dc.rightsNOTICE: this is the author’s version of a work that was accepted for publication in Medical hypotheses. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Medical hypotheses, [VOL 73, ISSUE 5, 2009] DOI 10.1016/j.mehy.2009.04.029-
dc.subject.meshModels, Theoretical-
dc.subject.meshNeurons - transplantation-
dc.subject.meshParkinson Disease - therapy-
dc.subject.meshStem Cell Transplantation-
dc.subject.meshTransplantation, Autologous-
dc.titleAutologous neural stem cell transplantation: A new treatment option for Parkinson's disease?en_US
dc.typeArticleen_US
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.mehy.2009.04.029-
dc.identifier.pmid19467573-
dc.identifier.scopuseid_2-s2.0-70349753165-
dc.identifier.hkuros170623-
dc.identifier.volume73-
dc.identifier.issue5-
dc.identifier.spage757-
dc.identifier.epage759-
dc.identifier.isiWOS:000271558000028-
dc.publisher.placeUnited Kingdom-

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