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Conference Paper: Hypertensive mice with over-expression of endothelin-1 show hyperactivity, impaired sensorimotor gating, mild cognitive deficit and cerebral vascular oxidative stress

TitleHypertensive mice with over-expression of endothelin-1 show hyperactivity, impaired sensorimotor gating, mild cognitive deficit and cerebral vascular oxidative stress
Authors
Issue Date2010
PublisherThe Federation of European Neuroscience Societies (FENS).
Citation
7th FENS Forum of European Neuroscience, Amsterdam, The Netherlands, 3-7 July 2010. In FENS Abstract, 2010, v. 5, p. Abstract no. 204.9 How to Cite?
AbstractPrevious studies showed that endothelin-1 (ET-1), a potent vasoconstrictor, is increased in the cerebrospinal fluid of dementia patients, suggesting that ET-1 might contribute to the impairment of cognitive function. This is supported by the observation that injection of ET-1 into the hippocampus of aged animals caused neuronal death, accompanied by learning and memory deficit. Since short-term effects of exogenously administered ET-1 may not stimulate the pathophysiological increase of ET-1, we examined the behavior of transgenic (TET-1) mice that overexpress ET-1 specifically in the endothelial cells. The behavioral changes and cognitive function were investigated in young (5-6 months) and aged (21-23 months) TET-1 mice under normal rearing conditions. Compared to the age-matched non-transgenic mice, the aged TET-1 mice displayed significantly higher locomotor activity in open field test, impairment in sensorimotor gating in pre-pulse inhibition of the acoustic startle response test, and a trend of spatial learning and memory deficit in Morris water maze test. The aged TET-1 mice also showed increased expression of heat-shock protein 70 (Hsp-70), hypoxia induced factor-1 alpha (HIF-1 alpha) and gp91phox, a subunit of NADPH oxidase, in the endothelial cells of cerebral vessels of the prefrontal cortex, suggesting that over-expression of endothelial ET-1 induces oxidative stress. In addition, glutamate expression was also increased in the prefrontal cortex of the aged TET-1 mice, suggesting that glutamate neurotransmission was also affected. These changes might account for the hyperactivity, impaired sensorimotor gating and mild cognitive deficit due to over-expression of ET-1 in the cerebrovascular endothelial cells.
Persistent Identifierhttp://hdl.handle.net/10722/161592

 

DC FieldValueLanguage
dc.contributor.authorZhang, X-
dc.contributor.authorChung, SSM-
dc.contributor.authorChung, SK-
dc.date.accessioned2012-09-03T06:24:49Z-
dc.date.available2012-09-03T06:24:49Z-
dc.date.issued2010-
dc.identifier.citation7th FENS Forum of European Neuroscience, Amsterdam, The Netherlands, 3-7 July 2010. In FENS Abstract, 2010, v. 5, p. Abstract no. 204.9-
dc.identifier.urihttp://hdl.handle.net/10722/161592-
dc.description.abstractPrevious studies showed that endothelin-1 (ET-1), a potent vasoconstrictor, is increased in the cerebrospinal fluid of dementia patients, suggesting that ET-1 might contribute to the impairment of cognitive function. This is supported by the observation that injection of ET-1 into the hippocampus of aged animals caused neuronal death, accompanied by learning and memory deficit. Since short-term effects of exogenously administered ET-1 may not stimulate the pathophysiological increase of ET-1, we examined the behavior of transgenic (TET-1) mice that overexpress ET-1 specifically in the endothelial cells. The behavioral changes and cognitive function were investigated in young (5-6 months) and aged (21-23 months) TET-1 mice under normal rearing conditions. Compared to the age-matched non-transgenic mice, the aged TET-1 mice displayed significantly higher locomotor activity in open field test, impairment in sensorimotor gating in pre-pulse inhibition of the acoustic startle response test, and a trend of spatial learning and memory deficit in Morris water maze test. The aged TET-1 mice also showed increased expression of heat-shock protein 70 (Hsp-70), hypoxia induced factor-1 alpha (HIF-1 alpha) and gp91phox, a subunit of NADPH oxidase, in the endothelial cells of cerebral vessels of the prefrontal cortex, suggesting that over-expression of endothelial ET-1 induces oxidative stress. In addition, glutamate expression was also increased in the prefrontal cortex of the aged TET-1 mice, suggesting that glutamate neurotransmission was also affected. These changes might account for the hyperactivity, impaired sensorimotor gating and mild cognitive deficit due to over-expression of ET-1 in the cerebrovascular endothelial cells.-
dc.languageeng-
dc.publisherThe Federation of European Neuroscience Societies (FENS).-
dc.relation.ispartofFENS Abstract-
dc.titleHypertensive mice with over-expression of endothelin-1 show hyperactivity, impaired sensorimotor gating, mild cognitive deficit and cerebral vascular oxidative stressen_US
dc.typeConference_Paperen_US
dc.identifier.emailChung, SSM: smchung@hkucc.hku.hk-
dc.identifier.emailChung, SK: skchung@hkucc.hku.hk-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.hkuros184964-
dc.identifier.volume5-
dc.identifier.spageAbstract no. 204.9-
dc.identifier.epageAbstract no. 204.9-
dc.publisher.placeThe Netherlands-
dc.description.other7th FENS Forum of European Neuroscience, Amsterdam, The Netherlands, 3-7 July 2010. In FENS Abstract, 2010, v. 5, p. Abstract no. 204.9-

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