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Article: Immunomodulatory activity of 3β,6β-dihydroxyolean-12-en-27-oic acid in tumor-bearing mice

TitleImmunomodulatory activity of 3β,6β-dihydroxyolean-12-en-27-oic acid in tumor-bearing mice
Authors
Issue Date2009
PublisherWiley - V C H Verlag GmbH & Co KGaA. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/106056929
Citation
Chemistry And Biodiversity, 2009, v. 6 n. 8, p. 1243-1253 How to Cite?
Abstract3β,6β-Dihydroxyolean-12-en-27-oic acid (1) is a pentacyclic triterpenoid isolated from the rhizomes of Astilbe chinensis. To evaluate the in vivo antitumor potential and to elucidate its immunological mechanisms, effect of 1 on the growth of mouse-transplantable tumors, and the immune response in naive and tumor-bearing mice were investigated. The mice inoculated with mouse tumor cell lines were orally treated with 1 at the doses of 40, 60, and 80 mg/kg for 10 days. The effects of 1 on the growth of mouse-transplantable S180 sarcoma and H22 hepatoma, splenocyte proliferation, cytotoxic T lymphocyte (CTL) activity, natural killer (NK) cell activity, and production of interleukin-2 (IL-2) from splenocytes in S180-bearing mice were measured. Furthermore, the effect of 1 on 2,4-dinitrofluorobenzene (DNFB)-induced delayed-type hypersensitivity (DTH) reactions and the sheep red blood cell (SRBC)-induced antibody response in naive mice were also studied. Compound 1 could not only significantly inhibit the growth of mouse transplantable S180 sarcoma and H22 hepatoma, increase splenocytes proliferation, CTL and NK cell activity, and the level of IL-2 secreted by splenocytes in tumor-bearing mice, but also remarkably promote the DTH reaction and enhance anti-SRBC antibody titers in naive mice. These results suggested that 1 could improve both cellular and humoral immune response, and could act as antitumor agent with immunomodulatory activity. © 2009 Verlag Helvetica Chimica Acta AG.
Persistent Identifierhttp://hdl.handle.net/10722/161286
ISSN
2015 Impact Factor: 1.444
2015 SCImago Journal Rankings: 0.542
References

 

DC FieldValueLanguage
dc.contributor.authorDeng, Wen_US
dc.contributor.authorSun, HXen_US
dc.contributor.authorChen, FYen_US
dc.contributor.authorYao, MLen_US
dc.date.accessioned2012-08-24T08:29:28Z-
dc.date.available2012-08-24T08:29:28Z-
dc.date.issued2009en_US
dc.identifier.citationChemistry And Biodiversity, 2009, v. 6 n. 8, p. 1243-1253en_US
dc.identifier.issn1612-1872en_US
dc.identifier.urihttp://hdl.handle.net/10722/161286-
dc.description.abstract3β,6β-Dihydroxyolean-12-en-27-oic acid (1) is a pentacyclic triterpenoid isolated from the rhizomes of Astilbe chinensis. To evaluate the in vivo antitumor potential and to elucidate its immunological mechanisms, effect of 1 on the growth of mouse-transplantable tumors, and the immune response in naive and tumor-bearing mice were investigated. The mice inoculated with mouse tumor cell lines were orally treated with 1 at the doses of 40, 60, and 80 mg/kg for 10 days. The effects of 1 on the growth of mouse-transplantable S180 sarcoma and H22 hepatoma, splenocyte proliferation, cytotoxic T lymphocyte (CTL) activity, natural killer (NK) cell activity, and production of interleukin-2 (IL-2) from splenocytes in S180-bearing mice were measured. Furthermore, the effect of 1 on 2,4-dinitrofluorobenzene (DNFB)-induced delayed-type hypersensitivity (DTH) reactions and the sheep red blood cell (SRBC)-induced antibody response in naive mice were also studied. Compound 1 could not only significantly inhibit the growth of mouse transplantable S180 sarcoma and H22 hepatoma, increase splenocytes proliferation, CTL and NK cell activity, and the level of IL-2 secreted by splenocytes in tumor-bearing mice, but also remarkably promote the DTH reaction and enhance anti-SRBC antibody titers in naive mice. These results suggested that 1 could improve both cellular and humoral immune response, and could act as antitumor agent with immunomodulatory activity. © 2009 Verlag Helvetica Chimica Acta AG.en_US
dc.languageengen_US
dc.publisherWiley - V C H Verlag GmbH & Co KGaA. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/106056929en_US
dc.relation.ispartofChemistry and Biodiversityen_US
dc.titleImmunomodulatory activity of 3β,6β-dihydroxyolean-12-en-27-oic acid in tumor-bearing miceen_US
dc.typeArticleen_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1002/cbdv.200800187en_US
dc.identifier.scopuseid_2-s2.0-69449099901en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-69449099901&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume6en_US
dc.identifier.issue8en_US
dc.identifier.spage1243en_US
dc.identifier.epage1253en_US
dc.publisher.placeGermanyen_US

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