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Article: Manganese superoxide dismutase expressed in silkworm larvae, Bombyx mori L enhances the NK activity and splenocyte proliferation against Sarcoma 180 tumor cells in vivo

TitleManganese superoxide dismutase expressed in silkworm larvae, Bombyx mori L enhances the NK activity and splenocyte proliferation against Sarcoma 180 tumor cells in vivo
Authors
Issue Date2009
PublisherSpringer Verlag Dordrecht. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=0301-4851
Citation
Molecular Biology Reports, 2009, v. 36 n. 1, p. 187-192 How to Cite?
AbstractNatural killer cell (NK) is known as a major immune system in body through mediating cell death via several possible pathways, and one of three subpopulations of lymphocytes functioning as scavenger of tumor, virus infected cells etc. Our present results found that the SOD-contained silkworm larvae powder caused an enhancement of the effect on NK cell cytotoxicity, which implied this material modulated the immune system in mice in vivo. The NK cell activities of S180 tumor modeled mice treated with silkworm powder including SOD were enhanced significantly ranging from 30% to 48%, respectively, compare to a distilled water feeding control and silkworm powder without SOD. Meanwhile, the ConA-stimulated splenocyte proliferation of all three treated groups was higher than that of the control both in T cells or B cells. The average tumor weight of S180 modeled mice treated with doses of SOD-contained silkworm powder was lighter than that of water control showing the tumor inhibition rates (IR) reached to 22.51% to 37%, respectively. In conclusion, these findings demonstrate that administration of silkworm larvae powder containing SOD results in activation of NK cells and immune T-cell and B-cell, suggesting the silkworm larvae powder containing SOD play a positive role in tumor inhibition. © 2007 Springer Science+Business Media B.V.
Persistent Identifierhttp://hdl.handle.net/10722/161284
ISSN
2015 Impact Factor: 1.698
2015 SCImago Journal Rankings: 0.730
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorYue, WFen_US
dc.contributor.authorYao, MLen_US
dc.contributor.authorLiu, JMen_US
dc.contributor.authorLi, GLen_US
dc.contributor.authorLi, XHen_US
dc.contributor.authorWu, XFen_US
dc.contributor.authorDeng, Wen_US
dc.contributor.authorSun, HXen_US
dc.contributor.authorZhou, JYen_US
dc.contributor.authorZhang, CXen_US
dc.contributor.authorMiao, YGen_US
dc.date.accessioned2012-08-24T08:29:26Z-
dc.date.available2012-08-24T08:29:26Z-
dc.date.issued2009en_US
dc.identifier.citationMolecular Biology Reports, 2009, v. 36 n. 1, p. 187-192en_US
dc.identifier.issn0301-4851en_US
dc.identifier.urihttp://hdl.handle.net/10722/161284-
dc.description.abstractNatural killer cell (NK) is known as a major immune system in body through mediating cell death via several possible pathways, and one of three subpopulations of lymphocytes functioning as scavenger of tumor, virus infected cells etc. Our present results found that the SOD-contained silkworm larvae powder caused an enhancement of the effect on NK cell cytotoxicity, which implied this material modulated the immune system in mice in vivo. The NK cell activities of S180 tumor modeled mice treated with silkworm powder including SOD were enhanced significantly ranging from 30% to 48%, respectively, compare to a distilled water feeding control and silkworm powder without SOD. Meanwhile, the ConA-stimulated splenocyte proliferation of all three treated groups was higher than that of the control both in T cells or B cells. The average tumor weight of S180 modeled mice treated with doses of SOD-contained silkworm powder was lighter than that of water control showing the tumor inhibition rates (IR) reached to 22.51% to 37%, respectively. In conclusion, these findings demonstrate that administration of silkworm larvae powder containing SOD results in activation of NK cells and immune T-cell and B-cell, suggesting the silkworm larvae powder containing SOD play a positive role in tumor inhibition. © 2007 Springer Science+Business Media B.V.en_US
dc.languageengen_US
dc.publisherSpringer Verlag Dordrecht. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=0301-4851en_US
dc.relation.ispartofMolecular Biology Reportsen_US
dc.subject.meshAnimalsen_US
dc.subject.meshBody Weighten_US
dc.subject.meshBombyx - Chemistry - Enzymologyen_US
dc.subject.meshCell Proliferation - Drug Effectsen_US
dc.subject.meshFemaleen_US
dc.subject.meshInsect Proteins - Metabolism - Pharmacologyen_US
dc.subject.meshKiller Cells, Natural - Metabolismen_US
dc.subject.meshLarva - Chemistry - Enzymologyen_US
dc.subject.meshLymphocyte Activation - Drug Effectsen_US
dc.subject.meshMaleen_US
dc.subject.meshMiceen_US
dc.subject.meshSarcoma 180 - Metabolismen_US
dc.subject.meshSpleen - Cytologyen_US
dc.subject.meshSuperoxide Dismutase - Metabolism - Pharmacologyen_US
dc.titleManganese superoxide dismutase expressed in silkworm larvae, Bombyx mori L enhances the NK activity and splenocyte proliferation against Sarcoma 180 tumor cells in vivoen_US
dc.typeArticleen_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1007/s11033-007-9165-4en_US
dc.identifier.pmid17934870-
dc.identifier.scopuseid_2-s2.0-56649123322en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-56649123322&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume36en_US
dc.identifier.issue1en_US
dc.identifier.spage187en_US
dc.identifier.epage192en_US
dc.identifier.isiWOS:000262088100025-
dc.publisher.placeNetherlandsen_US

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