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Article: The genetic and environmental determinants of the association between brain abnormalities and schizophrenia: The schizophrenia twins and relatives consortium

TitleThe genetic and environmental determinants of the association between brain abnormalities and schizophrenia: The schizophrenia twins and relatives consortium
Authors
KeywordsBrain Volumes
Multicenter
Phenotypic Correlation
Schizophrenia
Smri
Twins
Issue Date2012
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/biopsychiat
Citation
Biological Psychiatry, 2012, v. 71 n. 10, p. 915-921 How to Cite?
AbstractBackground: Structural brain abnormalities are consistently found in schizophrenia (Sz) and have been associated with the familial risk for the disorder. We aim to define the relative contributions of genetic and nongenetic factors to the association between structural brain abnormalities and Sz in a uniquely powered cohort (Schizophrenia Twins and Relatives consortium). Methods: An international multicenter magnetic resonance imaging collaboration was set up to pool magnetic resonance imaging scans from twin pairs in Utrecht (The Netherlands), Helsinki (Finland), London (United Kingdom), and Jena (Germany). A sample of 684 subjects took part, consisting of monozygotic twins (n = 410, with 51 patients from concordant and 52 from discordant pairs) and dizygotic twins (n = 274, with 39 patients from discordant pairs). The additive genetic, common, and unique environmental contributions to the association between brain volumes and risk for Sz were estimated by structural equation modeling. Results: The heritabilities of most brain volumes were significant and ranged between 52% (temporal cortical gray matter) and 76% (cerebrum). Heritability of cerebral gray matter did not reach significance (34%). Significant phenotypic correlations were found between Sz and reduced volumes of the cerebrum (-.22 [-.30/-.14]) and white matter (-.17 [-.25/-.09]) and increased volume of the third ventricle (.18 [.08/.28]). These were predominantly due to overlapping genetic effects (77%, 94%, and 83%, respectively). Conclusions: Some of the genes that transmit the risk for Sz also influence cerebral (white matter) volume. © 2012 Society of Biological Psychiatry.
Persistent Identifierhttp://hdl.handle.net/10722/161258
ISSN
2015 Impact Factor: 11.212
2015 SCImago Journal Rankings: 5.823
PubMed Central ID
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorVan Haren, NEMen_US
dc.contributor.authorRijsdijk, Fen_US
dc.contributor.authorSchnack, HGen_US
dc.contributor.authorPicchioni, MMen_US
dc.contributor.authorToulopoulou, Ten_US
dc.contributor.authorWeisbrod, Men_US
dc.contributor.authorSauer, Hen_US
dc.contributor.authorVan Erp, TGen_US
dc.contributor.authorCannon, TDen_US
dc.contributor.authorHuttunen, MOen_US
dc.contributor.authorBoomsma, DIen_US
dc.contributor.authorHulshoff Pol, HEen_US
dc.contributor.authorMurray, RMen_US
dc.contributor.authorKahn, RSen_US
dc.date.accessioned2012-08-23T06:11:32Z-
dc.date.available2012-08-23T06:11:32Z-
dc.date.issued2012en_US
dc.identifier.citationBiological Psychiatry, 2012, v. 71 n. 10, p. 915-921en_US
dc.identifier.issn0006-3223en_US
dc.identifier.urihttp://hdl.handle.net/10722/161258-
dc.description.abstractBackground: Structural brain abnormalities are consistently found in schizophrenia (Sz) and have been associated with the familial risk for the disorder. We aim to define the relative contributions of genetic and nongenetic factors to the association between structural brain abnormalities and Sz in a uniquely powered cohort (Schizophrenia Twins and Relatives consortium). Methods: An international multicenter magnetic resonance imaging collaboration was set up to pool magnetic resonance imaging scans from twin pairs in Utrecht (The Netherlands), Helsinki (Finland), London (United Kingdom), and Jena (Germany). A sample of 684 subjects took part, consisting of monozygotic twins (n = 410, with 51 patients from concordant and 52 from discordant pairs) and dizygotic twins (n = 274, with 39 patients from discordant pairs). The additive genetic, common, and unique environmental contributions to the association between brain volumes and risk for Sz were estimated by structural equation modeling. Results: The heritabilities of most brain volumes were significant and ranged between 52% (temporal cortical gray matter) and 76% (cerebrum). Heritability of cerebral gray matter did not reach significance (34%). Significant phenotypic correlations were found between Sz and reduced volumes of the cerebrum (-.22 [-.30/-.14]) and white matter (-.17 [-.25/-.09]) and increased volume of the third ventricle (.18 [.08/.28]). These were predominantly due to overlapping genetic effects (77%, 94%, and 83%, respectively). Conclusions: Some of the genes that transmit the risk for Sz also influence cerebral (white matter) volume. © 2012 Society of Biological Psychiatry.en_US
dc.languageengen_US
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/biopsychiaten_US
dc.relation.ispartofBiological Psychiatryen_US
dc.subjectBrain Volumesen_US
dc.subjectMulticenteren_US
dc.subjectPhenotypic Correlationen_US
dc.subjectSchizophreniaen_US
dc.subjectSmrien_US
dc.subjectTwinsen_US
dc.titleThe genetic and environmental determinants of the association between brain abnormalities and schizophrenia: The schizophrenia twins and relatives consortiumen_US
dc.typeArticleen_US
dc.identifier.emailToulopoulou, T:timothea@hku.hken_US
dc.identifier.authorityToulopoulou, T=rp01542en_US
dc.description.naturelink_to_OA_fulltexten_US
dc.identifier.doi10.1016/j.biopsych.2012.01.010en_US
dc.identifier.pmid22341827-
dc.identifier.pmcidPMC3343260-
dc.identifier.scopuseid_2-s2.0-84860159631en_US
dc.identifier.hkuros223341-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-84860159631&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume71en_US
dc.identifier.issue10en_US
dc.identifier.spage915en_US
dc.identifier.epage921en_US
dc.identifier.isiWOS:000303104900011-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridVan Haren, NEM=6603501057en_US
dc.identifier.scopusauthoridRijsdijk, F=6701830835en_US
dc.identifier.scopusauthoridSchnack, HG=7005925946en_US
dc.identifier.scopusauthoridPicchioni, MM=6507443795en_US
dc.identifier.scopusauthoridToulopoulou, T=8855468700en_US
dc.identifier.scopusauthoridWeisbrod, M=7003679476en_US
dc.identifier.scopusauthoridSauer, H=7201911878en_US
dc.identifier.scopusauthoridVan Erp, TG=6604055278en_US
dc.identifier.scopusauthoridCannon, TD=7102610264en_US
dc.identifier.scopusauthoridHuttunen, MO=35217924900en_US
dc.identifier.scopusauthoridBoomsma, DI=35378012400en_US
dc.identifier.scopusauthoridHulshoff Pol, HE=6603905466en_US
dc.identifier.scopusauthoridMurray, RM=35406239400en_US
dc.identifier.scopusauthoridKahn, RS=7201463706en_US
dc.identifier.citeulike10368527-

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