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Article: Risk variant of oligodendrocyte lineage transcription factor 2 is associated with reduced white matter integrity

TitleRisk variant of oligodendrocyte lineage transcription factor 2 is associated with reduced white matter integrity
Authors
KeywordsDiffusion Tensor Imaging
Fractional Anisotropy
Genetics
Myelin
Schizophrenia
Issue Date2013
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/38751
Citation
Human Brain Mapping, 2013, v. 34 n. 9, p. 2025-2031 How to Cite?
AbstractThe oligodendrocyte lineage transcription factor 2 (OLIG2) regulates the genesis of oligodendrocytes, the brain cells responsible for axonal myelination. Although it has been associated with psychiatric and neurological disorders, the impact of this gene on white matter integrity has never been investigated in humans. Using diffusion tensor imaging, we examined the effect of a single nucleotide polymorphism (rs1059004) in OLIG2 previously associated with reduced gene expression, and with psychiatric disorders on fractional anisotropy in 78 healthy subjects. We found that the risk allele (A) was associated with reduced white matter integrity in the corona radiata bilaterally. This is consistent with evidence that it is a schizophrenia susceptibility gene, and suggests that it may confer increased risk through an effect on neuroanatomical connectivity. Hum Brain Mapp, 2012. © 2012 Wiley Periodicals, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/161257
ISSN
2014 Impact Factor: 5.969
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorPrata, DPen_US
dc.contributor.authorKanaan, RAen_US
dc.contributor.authorBarker, GJen_US
dc.contributor.authorShergill, Sen_US
dc.contributor.authorWoolley, Jen_US
dc.contributor.authorGeorgieva, Len_US
dc.contributor.authorPicchioni, MMen_US
dc.contributor.authorKravariti, Een_US
dc.contributor.authorWalshe, Men_US
dc.contributor.authorAllin, Men_US
dc.contributor.authorToulopoulou, Ten_US
dc.contributor.authorBramon, Een_US
dc.contributor.authorMcdonald, Cen_US
dc.contributor.authorGiampietro, Ven_US
dc.contributor.authorMurray, RMen_US
dc.contributor.authorBrammer, Men_US
dc.contributor.authorO'donovan, Men_US
dc.contributor.authorMcguire, Pen_US
dc.date.accessioned2012-08-23T06:11:31Z-
dc.date.available2012-08-23T06:11:31Z-
dc.date.issued2013en_US
dc.identifier.citationHuman Brain Mapping, 2013, v. 34 n. 9, p. 2025-2031en_US
dc.identifier.issn1065-9471en_US
dc.identifier.urihttp://hdl.handle.net/10722/161257-
dc.description.abstractThe oligodendrocyte lineage transcription factor 2 (OLIG2) regulates the genesis of oligodendrocytes, the brain cells responsible for axonal myelination. Although it has been associated with psychiatric and neurological disorders, the impact of this gene on white matter integrity has never been investigated in humans. Using diffusion tensor imaging, we examined the effect of a single nucleotide polymorphism (rs1059004) in OLIG2 previously associated with reduced gene expression, and with psychiatric disorders on fractional anisotropy in 78 healthy subjects. We found that the risk allele (A) was associated with reduced white matter integrity in the corona radiata bilaterally. This is consistent with evidence that it is a schizophrenia susceptibility gene, and suggests that it may confer increased risk through an effect on neuroanatomical connectivity. Hum Brain Mapp, 2012. © 2012 Wiley Periodicals, Inc.en_US
dc.languageengen_US
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/38751en_US
dc.relation.ispartofHuman Brain Mappingen_US
dc.subjectDiffusion Tensor Imagingen_US
dc.subjectFractional Anisotropyen_US
dc.subjectGeneticsen_US
dc.subjectMyelinen_US
dc.subjectSchizophreniaen_US
dc.titleRisk variant of oligodendrocyte lineage transcription factor 2 is associated with reduced white matter integrityen_US
dc.typeArticleen_US
dc.identifier.emailToulopoulou, T:timothea@hku.hken_US
dc.identifier.authorityToulopoulou, T=rp01542en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1002/hbm.22045en_US
dc.identifier.pmid22505278-
dc.identifier.scopuseid_2-s2.0-84882596068en_US
dc.identifier.hkuros223339-
dc.identifier.isiWOS:000323320800003-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridPrata, DP=14632352500en_US
dc.identifier.scopusauthoridKanaan, RA=12545783400en_US
dc.identifier.scopusauthoridBarker, GJ=55089196800en_US
dc.identifier.scopusauthoridShergill, S=35433190700en_US
dc.identifier.scopusauthoridWoolley, J=7102945377en_US
dc.identifier.scopusauthoridGeorgieva, L=6701324738en_US
dc.identifier.scopusauthoridPicchioni, MM=6507443795en_US
dc.identifier.scopusauthoridKravariti, E=8855469000en_US
dc.identifier.scopusauthoridWalshe, M=8855469300en_US
dc.identifier.scopusauthoridAllin, M=6602830090en_US
dc.identifier.scopusauthoridToulopoulou, T=8855468700en_US
dc.identifier.scopusauthoridBramon, E=8089378900en_US
dc.identifier.scopusauthoridMcdonald, C=55119657300en_US
dc.identifier.scopusauthoridGiampietro, V=6602160284en_US
dc.identifier.scopusauthoridMurray, RM=46761365300en_US
dc.identifier.scopusauthoridBrammer, M=55141377800en_US
dc.identifier.scopusauthoridO'Donovan, M=7103147367en_US
dc.identifier.scopusauthoridMcguire, P=7101880438en_US

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