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Article: Risk variant of oligodendrocyte lineage transcription factor 2 is associated with reduced white matter integrity
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TitleRisk variant of oligodendrocyte lineage transcription factor 2 is associated with reduced white matter integrity
 
AuthorsPrata, DP1
Kanaan, RA1
Barker, GJ1
Shergill, S1
Woolley, J1
Georgieva, L2
Picchioni, MM1
Kravariti, E1
Walshe, M1
Allin, M1
Toulopoulou, T1
Bramon, E1
Mcdonald, C3
Giampietro, V1
Murray, RM1
Brammer, M1
O'donovan, M2
Mcguire, P1
 
KeywordsDiffusion Tensor Imaging
Fractional Anisotropy
Genetics
Myelin
Schizophrenia
 
Issue Date2013
 
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/38751
 
CitationHuman Brain Mapping, 2013, v. 34 n. 9, p. 2025-2031 [How to Cite?]
DOI: http://dx.doi.org/10.1002/hbm.22045
 
AbstractThe oligodendrocyte lineage transcription factor 2 (OLIG2) regulates the genesis of oligodendrocytes, the brain cells responsible for axonal myelination. Although it has been associated with psychiatric and neurological disorders, the impact of this gene on white matter integrity has never been investigated in humans. Using diffusion tensor imaging, we examined the effect of a single nucleotide polymorphism (rs1059004) in OLIG2 previously associated with reduced gene expression, and with psychiatric disorders on fractional anisotropy in 78 healthy subjects. We found that the risk allele (A) was associated with reduced white matter integrity in the corona radiata bilaterally. This is consistent with evidence that it is a schizophrenia susceptibility gene, and suggests that it may confer increased risk through an effect on neuroanatomical connectivity. Hum Brain Mapp, 2012. © 2012 Wiley Periodicals, Inc.
 
ISSN1065-9471
2012 Impact Factor: 6.878
2012 SCImago Journal Rankings: 3.002
 
DOIhttp://dx.doi.org/10.1002/hbm.22045
 
DC FieldValue
dc.contributor.authorPrata, DP
 
dc.contributor.authorKanaan, RA
 
dc.contributor.authorBarker, GJ
 
dc.contributor.authorShergill, S
 
dc.contributor.authorWoolley, J
 
dc.contributor.authorGeorgieva, L
 
dc.contributor.authorPicchioni, MM
 
dc.contributor.authorKravariti, E
 
dc.contributor.authorWalshe, M
 
dc.contributor.authorAllin, M
 
dc.contributor.authorToulopoulou, T
 
dc.contributor.authorBramon, E
 
dc.contributor.authorMcdonald, C
 
dc.contributor.authorGiampietro, V
 
dc.contributor.authorMurray, RM
 
dc.contributor.authorBrammer, M
 
dc.contributor.authorO'donovan, M
 
dc.contributor.authorMcguire, P
 
dc.date.accessioned2012-08-23T06:11:31Z
 
dc.date.available2012-08-23T06:11:31Z
 
dc.date.issued2013
 
dc.description.abstractThe oligodendrocyte lineage transcription factor 2 (OLIG2) regulates the genesis of oligodendrocytes, the brain cells responsible for axonal myelination. Although it has been associated with psychiatric and neurological disorders, the impact of this gene on white matter integrity has never been investigated in humans. Using diffusion tensor imaging, we examined the effect of a single nucleotide polymorphism (rs1059004) in OLIG2 previously associated with reduced gene expression, and with psychiatric disorders on fractional anisotropy in 78 healthy subjects. We found that the risk allele (A) was associated with reduced white matter integrity in the corona radiata bilaterally. This is consistent with evidence that it is a schizophrenia susceptibility gene, and suggests that it may confer increased risk through an effect on neuroanatomical connectivity. Hum Brain Mapp, 2012. © 2012 Wiley Periodicals, Inc.
 
dc.description.natureLink_to_subscribed_fulltext
 
dc.identifier.citationHuman Brain Mapping, 2013, v. 34 n. 9, p. 2025-2031 [How to Cite?]
DOI: http://dx.doi.org/10.1002/hbm.22045
 
dc.identifier.doihttp://dx.doi.org/10.1002/hbm.22045
 
dc.identifier.hkuros223339
 
dc.identifier.issn1065-9471
2012 Impact Factor: 6.878
2012 SCImago Journal Rankings: 3.002
 
dc.identifier.pmid22505278
 
dc.identifier.scopuseid_2-s2.0-84882596068
 
dc.identifier.urihttp://hdl.handle.net/10722/161257
 
dc.languageeng
 
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/38751
 
dc.publisher.placeUnited States
 
dc.relation.ispartofHuman Brain Mapping
 
dc.subjectDiffusion Tensor Imaging
 
dc.subjectFractional Anisotropy
 
dc.subjectGenetics
 
dc.subjectMyelin
 
dc.subjectSchizophrenia
 
dc.titleRisk variant of oligodendrocyte lineage transcription factor 2 is associated with reduced white matter integrity
 
dc.typeArticle
 
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<contributor.author>Kanaan, RA</contributor.author>
<contributor.author>Barker, GJ</contributor.author>
<contributor.author>Shergill, S</contributor.author>
<contributor.author>Woolley, J</contributor.author>
<contributor.author>Georgieva, L</contributor.author>
<contributor.author>Picchioni, MM</contributor.author>
<contributor.author>Kravariti, E</contributor.author>
<contributor.author>Walshe, M</contributor.author>
<contributor.author>Allin, M</contributor.author>
<contributor.author>Toulopoulou, T</contributor.author>
<contributor.author>Bramon, E</contributor.author>
<contributor.author>Mcdonald, C</contributor.author>
<contributor.author>Giampietro, V</contributor.author>
<contributor.author>Murray, RM</contributor.author>
<contributor.author>Brammer, M</contributor.author>
<contributor.author>O&apos;donovan, M</contributor.author>
<contributor.author>Mcguire, P</contributor.author>
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<description.abstract>The oligodendrocyte lineage transcription factor 2 (OLIG2) regulates the genesis of oligodendrocytes, the brain cells responsible for axonal myelination. Although it has been associated with psychiatric and neurological disorders, the impact of this gene on white matter integrity has never been investigated in humans. Using diffusion tensor imaging, we examined the effect of a single nucleotide polymorphism (rs1059004) in OLIG2 previously associated with reduced gene expression, and with psychiatric disorders on fractional anisotropy in 78 healthy subjects. We found that the risk allele (A) was associated with reduced white matter integrity in the corona radiata bilaterally. This is consistent with evidence that it is a schizophrenia susceptibility gene, and suggests that it may confer increased risk through an effect on neuroanatomical connectivity. Hum Brain Mapp, 2012. &#169; 2012 Wiley Periodicals, Inc.</description.abstract>
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<subject>Diffusion Tensor Imaging</subject>
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Author Affiliations
  1. King's College London
  2. Cardiff University
  3. National University of Ireland Galway