Article: Risk variant of oligodendrocyte lineage transcription factor 2 is associated with reduced white matter integrity

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TitleRisk variant of oligodendrocyte lineage transcription factor 2 is associated with reduced white matter integrity
AuthorsPrata, DP1
Kanaan, RA1
Barker, GJ1
Shergill, S1
Woolley, J1
Georgieva, L2
Picchioni, MM1
Kravariti, E1
Walshe, M1
Allin, M1
Toulopoulou, T1
Bramon, E1
Mcdonald, C3
Giampietro, V1
Murray, RM1
Brammer, M1
O'donovan, M2
Mcguire, P1
KeywordsDiffusion Tensor Imaging
Fractional Anisotropy
Genetics
Myelin
Schizophrenia
Issue Date2012
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/38751
CitationHuman Brain Mapping, 2012 [How to Cite?]
DOI: http://dx.doi.org/10.1002/hbm.22045
AbstractThe oligodendrocyte lineage transcription factor 2 (OLIG2) regulates the genesis of oligodendrocytes, the brain cells responsible for axonal myelination. Although it has been associated with psychiatric and neurological disorders, the impact of this gene on white matter integrity has never been investigated in humans. Using diffusion tensor imaging, we examined the effect of a single nucleotide polymorphism (rs1059004) in OLIG2 previously associated with reduced gene expression, and with psychiatric disorders on fractional anisotropy in 78 healthy subjects. We found that the risk allele (A) was associated with reduced white matter integrity in the corona radiata bilaterally. This is consistent with evidence that it is a schizophrenia susceptibility gene, and suggests that it may confer increased risk through an effect on neuroanatomical connectivity. Hum Brain Mapp, 2012. © 2012 Wiley Periodicals, Inc.
ISSN1065-9471
2011 Impact Factor: 5.88
2011 SCImago Journal Rankings: 0.416
DOIhttp://dx.doi.org/10.1002/hbm.22045
DC Field
Value
dc.contributor.authorPrata, DP
dc.contributor.authorKanaan, RA
dc.contributor.authorBarker, GJ
dc.contributor.authorShergill, S
dc.contributor.authorWoolley, J
dc.contributor.authorGeorgieva, L
dc.contributor.authorPicchioni, MM
dc.contributor.authorKravariti, E
dc.contributor.authorWalshe, M
dc.contributor.authorAllin, M
dc.contributor.authorToulopoulou, T
dc.contributor.authorBramon, E
dc.contributor.authorMcdonald, C
dc.contributor.authorGiampietro, V
dc.contributor.authorMurray, RM
dc.contributor.authorBrammer, M
dc.contributor.authorO'donovan, M
dc.contributor.authorMcguire, P
dc.date.accessioned2012-08-23T06:11:31Z
dc.date.available2012-08-23T06:11:31Z
dc.date.issued2012
dc.description.abstractThe oligodendrocyte lineage transcription factor 2 (OLIG2) regulates the genesis of oligodendrocytes, the brain cells responsible for axonal myelination. Although it has been associated with psychiatric and neurological disorders, the impact of this gene on white matter integrity has never been investigated in humans. Using diffusion tensor imaging, we examined the effect of a single nucleotide polymorphism (rs1059004) in OLIG2 previously associated with reduced gene expression, and with psychiatric disorders on fractional anisotropy in 78 healthy subjects. We found that the risk allele (A) was associated with reduced white matter integrity in the corona radiata bilaterally. This is consistent with evidence that it is a schizophrenia susceptibility gene, and suggests that it may confer increased risk through an effect on neuroanatomical connectivity. Hum Brain Mapp, 2012. © 2012 Wiley Periodicals, Inc.
dc.description.natureLink_to_subscribed_fulltext
dc.identifier.citationHuman Brain Mapping, 2012 [How to Cite?]
DOI: http://dx.doi.org/10.1002/hbm.22045
dc.identifier.doihttp://dx.doi.org/10.1002/hbm.22045
dc.identifier.issn1065-9471
2011 Impact Factor: 5.88
2011 SCImago Journal Rankings: 0.416
dc.identifier.scopuseid_2-s2.0-84859707821
dc.identifier.urihttp://hdl.handle.net/10722/161257
dc.languageeng
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/38751
dc.publisher.placeUnited States
dc.relation.ispartofHuman Brain Mapping
dc.subjectDiffusion Tensor Imaging
dc.subjectFractional Anisotropy
dc.subjectGenetics
dc.subjectMyelin
dc.subjectSchizophrenia
dc.titleRisk variant of oligodendrocyte lineage transcription factor 2 is associated with reduced white matter integrity
dc.typeArticle
Author Affiliations
  1. King's College London
  2. Cardiff University
  3. National University of Ireland Galway