Article: Interaction between effects of genes coding for dopamine and glutamate transmission on striatal and parahippocampal function

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TitleInteraction between effects of genes coding for dopamine and glutamate transmission on striatal and parahippocampal function
AuthorsPauli, A1 2
Prata, DP1
Mechelli, A1
Picchioni, M1
Fu, CH1
Chaddock, CA1
Kane, F1
Kalidindi, S1
Mcdonald, C3
Kravariti, E2
Toulopoulou, T1
Bramon, E1
Walshe, M1
Ehlert, N
Georgiades, A1
Murray, R1
Collier, DA
Mcguire, P1
KeywordsDat
Epistasis
Imaging Genetics
Psychosis, Daoa/G72
Schizophrenia
Verbal Fluency
Issue Date2012
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/38751
CitationHuman Brain Mapping, 2012 [How to Cite?]
DOI: http://dx.doi.org/10.1002/hbm.22061
AbstractThe genes for the dopamine transporter (DAT) and the D-Amino acid oxidase activator (DAOA or G72) have been independently implicated in the risk for schizophrenia and in bipolar disorder and/or their related intermediate phenotypes. DAT and G72 respectively modulate central dopamine and glutamate transmission, the two systems most robustly implicated in these disorders. Contemporary studies have demonstrated that elevated dopamine function is associated with glutamatergic dysfunction in psychotic disorders. Using functional magnetic resonance imaging we examined whether there was an interaction between the effects of genes that influence dopamine and glutamate transmission (DAT and G72) on regional brain activation during verbal fluency, which is known to be abnormal in psychosis, in 80 healthy volunteers. Significant interactions between the effects of G72 and DAT polymorphisms on activation were evident in the striatum, parahippocampal gyrus, and supramarginal/angular gyri bilaterally, the right insula, in the right pre-/postcentral and the left posterior cingulate/retrosplenial gyri (P < 0.05, FDR-corrected across the whole brain). This provides evidence that interactions between the dopamine and the glutamate system, thought to be altered in psychosis, have an impact in executive processing which can be modulated by common genetic variation. © 2012 Wiley Periodicals, Inc.
ISSN1065-9471
2011 Impact Factor: 5.88
2011 SCImago Journal Rankings: 0.416
DOIhttp://dx.doi.org/10.1002/hbm.22061
DC Field
Value
dc.contributor.authorPauli, A
dc.contributor.authorPrata, DP
dc.contributor.authorMechelli, A
dc.contributor.authorPicchioni, M
dc.contributor.authorFu, CH
dc.contributor.authorChaddock, CA
dc.contributor.authorKane, F
dc.contributor.authorKalidindi, S
dc.contributor.authorMcdonald, C
dc.contributor.authorKravariti, E
dc.contributor.authorToulopoulou, T
dc.contributor.authorBramon, E
dc.contributor.authorWalshe, M
dc.contributor.authorEhlert, N
dc.contributor.authorGeorgiades, A
dc.contributor.authorMurray, R
dc.contributor.authorCollier, DA
dc.contributor.authorMcguire, P
dc.date.accessioned2012-08-23T06:11:30Z
dc.date.available2012-08-23T06:11:30Z
dc.date.issued2012
dc.description.abstractThe genes for the dopamine transporter (DAT) and the D-Amino acid oxidase activator (DAOA or G72) have been independently implicated in the risk for schizophrenia and in bipolar disorder and/or their related intermediate phenotypes. DAT and G72 respectively modulate central dopamine and glutamate transmission, the two systems most robustly implicated in these disorders. Contemporary studies have demonstrated that elevated dopamine function is associated with glutamatergic dysfunction in psychotic disorders. Using functional magnetic resonance imaging we examined whether there was an interaction between the effects of genes that influence dopamine and glutamate transmission (DAT and G72) on regional brain activation during verbal fluency, which is known to be abnormal in psychosis, in 80 healthy volunteers. Significant interactions between the effects of G72 and DAT polymorphisms on activation were evident in the striatum, parahippocampal gyrus, and supramarginal/angular gyri bilaterally, the right insula, in the right pre-/postcentral and the left posterior cingulate/retrosplenial gyri (P < 0.05, FDR-corrected across the whole brain). This provides evidence that interactions between the dopamine and the glutamate system, thought to be altered in psychosis, have an impact in executive processing which can be modulated by common genetic variation. © 2012 Wiley Periodicals, Inc.
dc.description.natureLink_to_subscribed_fulltext
dc.identifier.citationHuman Brain Mapping, 2012 [How to Cite?]
DOI: http://dx.doi.org/10.1002/hbm.22061
dc.identifier.doihttp://dx.doi.org/10.1002/hbm.22061
dc.identifier.issn1065-9471
2011 Impact Factor: 5.88
2011 SCImago Journal Rankings: 0.416
dc.identifier.scopuseid_2-s2.0-84858737420
dc.identifier.urihttp://hdl.handle.net/10722/161256
dc.languageeng
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/38751
dc.publisher.placeUnited States
dc.relation.ispartofHuman Brain Mapping
dc.subjectDat
dc.subjectEpistasis
dc.subjectImaging Genetics
dc.subjectPsychosis, Daoa/G72
dc.subjectSchizophrenia
dc.subjectVerbal Fluency
dc.titleInteraction between effects of genes coding for dopamine and glutamate transmission on striatal and parahippocampal function
dc.typeArticle
Author Affiliations
  1. King's College London
  2. UniversitätsSpital Bern
  3. National University of Ireland Galway