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Article: Interaction between effects of genes coding for dopamine and glutamate transmission on striatal and parahippocampal function

TitleInteraction between effects of genes coding for dopamine and glutamate transmission on striatal and parahippocampal function
Authors
KeywordsDat
Epistasis
Imaging Genetics
Psychosis, Daoa/G72
Schizophrenia
Verbal Fluency
Issue Date2013
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/38751
Citation
Human Brain Mapping, 2013, v. 34 n. 9, p. 2244-2258 How to Cite?
Abstract
The genes for the dopamine transporter (DAT) and the D-Amino acid oxidase activator (DAOA or G72) have been independently implicated in the risk for schizophrenia and in bipolar disorder and/or their related intermediate phenotypes. DAT and G72 respectively modulate central dopamine and glutamate transmission, the two systems most robustly implicated in these disorders. Contemporary studies have demonstrated that elevated dopamine function is associated with glutamatergic dysfunction in psychotic disorders. Using functional magnetic resonance imaging we examined whether there was an interaction between the effects of genes that influence dopamine and glutamate transmission (DAT and G72) on regional brain activation during verbal fluency, which is known to be abnormal in psychosis, in 80 healthy volunteers. Significant interactions between the effects of G72 and DAT polymorphisms on activation were evident in the striatum, parahippocampal gyrus, and supramarginal/angular gyri bilaterally, the right insula, in the right pre-/postcentral and the left posterior cingulate/retrosplenial gyri (P < 0.05, FDR-corrected across the whole brain). This provides evidence that interactions between the dopamine and the glutamate system, thought to be altered in psychosis, have an impact in executive processing which can be modulated by common genetic variation. © 2012 Wiley Periodicals, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/161256
ISSN
2013 Impact Factor: 6.924
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorPauli, Aen_US
dc.contributor.authorPrata, DPen_US
dc.contributor.authorMechelli, Aen_US
dc.contributor.authorPicchioni, Men_US
dc.contributor.authorFu, CHen_US
dc.contributor.authorChaddock, CAen_US
dc.contributor.authorKane, Fen_US
dc.contributor.authorKalidindi, Sen_US
dc.contributor.authorMcdonald, Cen_US
dc.contributor.authorKravariti, Een_US
dc.contributor.authorToulopoulou, Ten_US
dc.contributor.authorBramon, Een_US
dc.contributor.authorWalshe, Men_US
dc.contributor.authorEhlert, Nen_US
dc.contributor.authorGeorgiades, Aen_US
dc.contributor.authorMurray, Ren_US
dc.contributor.authorCollier, DAen_US
dc.contributor.authorMcguire, Pen_US
dc.date.accessioned2012-08-23T06:11:30Z-
dc.date.available2012-08-23T06:11:30Z-
dc.date.issued2013en_US
dc.identifier.citationHuman Brain Mapping, 2013, v. 34 n. 9, p. 2244-2258en_US
dc.identifier.issn1065-9471en_US
dc.identifier.urihttp://hdl.handle.net/10722/161256-
dc.description.abstractThe genes for the dopamine transporter (DAT) and the D-Amino acid oxidase activator (DAOA or G72) have been independently implicated in the risk for schizophrenia and in bipolar disorder and/or their related intermediate phenotypes. DAT and G72 respectively modulate central dopamine and glutamate transmission, the two systems most robustly implicated in these disorders. Contemporary studies have demonstrated that elevated dopamine function is associated with glutamatergic dysfunction in psychotic disorders. Using functional magnetic resonance imaging we examined whether there was an interaction between the effects of genes that influence dopamine and glutamate transmission (DAT and G72) on regional brain activation during verbal fluency, which is known to be abnormal in psychosis, in 80 healthy volunteers. Significant interactions between the effects of G72 and DAT polymorphisms on activation were evident in the striatum, parahippocampal gyrus, and supramarginal/angular gyri bilaterally, the right insula, in the right pre-/postcentral and the left posterior cingulate/retrosplenial gyri (P < 0.05, FDR-corrected across the whole brain). This provides evidence that interactions between the dopamine and the glutamate system, thought to be altered in psychosis, have an impact in executive processing which can be modulated by common genetic variation. © 2012 Wiley Periodicals, Inc.en_US
dc.languageengen_US
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/38751en_US
dc.relation.ispartofHuman Brain Mappingen_US
dc.subjectDaten_US
dc.subjectEpistasisen_US
dc.subjectImaging Geneticsen_US
dc.subjectPsychosis, Daoa/G72en_US
dc.subjectSchizophreniaen_US
dc.subjectVerbal Fluencyen_US
dc.titleInteraction between effects of genes coding for dopamine and glutamate transmission on striatal and parahippocampal functionen_US
dc.typeArticleen_US
dc.identifier.emailToulopoulou, T:timothea@hku.hken_US
dc.identifier.authorityToulopoulou, T=rp01542en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1002/hbm.22061en_US
dc.identifier.pmid22438288-
dc.identifier.scopuseid_2-s2.0-84882682482en_US
dc.identifier.hkuros223340-
dc.identifier.isiWOS:000323320800020-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridPauli, A=55124400400en_US
dc.identifier.scopusauthoridPrata, DP=14632352500en_US
dc.identifier.scopusauthoridMechelli, A=6603693131en_US
dc.identifier.scopusauthoridPicchioni, M=6507443795en_US
dc.identifier.scopusauthoridFu, CH=55124120200en_US
dc.identifier.scopusauthoridChaddock, CA=26655265600en_US
dc.identifier.scopusauthoridKane, F=24829114900en_US
dc.identifier.scopusauthoridKalidindi, S=24366595400en_US
dc.identifier.scopusauthoridMcdonald, C=55119657300en_US
dc.identifier.scopusauthoridKravariti, E=8855469000en_US
dc.identifier.scopusauthoridToulopoulou, T=8855468700en_US
dc.identifier.scopusauthoridBramon, E=8089378900en_US
dc.identifier.scopusauthoridWalshe, M=8855469300en_US
dc.identifier.scopusauthoridEhlert, N=55122654300en_US
dc.identifier.scopusauthoridGeorgiades, A=35233211400en_US
dc.identifier.scopusauthoridMurray, R=35406239400en_US
dc.identifier.scopusauthoridCollier, DA=55122067500en_US
dc.identifier.scopusauthoridMcguire, P=7101880438en_US

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