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Article: Interaction between effects of genes coding for dopamine and glutamate transmission on striatal and parahippocampal function
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TitleInteraction between effects of genes coding for dopamine and glutamate transmission on striatal and parahippocampal function
 
AuthorsPauli, A1 2
Prata, DP1
Mechelli, A1
Picchioni, M1
Fu, CH
Chaddock, CA1
Kane, F1
Kalidindi, S1
Mcdonald, C3
Kravariti, E2
Toulopoulou, T1
Bramon, E1
Walshe, M1
Ehlert, N1
Georgiades, A1
Murray, R1
Collier, DA1
Mcguire, P1
 
KeywordsDat
Epistasis
Imaging Genetics
Psychosis, Daoa/G72
Schizophrenia
Verbal Fluency
 
Issue Date2013
 
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/38751
 
CitationHuman Brain Mapping, 2013, v. 34 n. 9, p. 2244-2258 [How to Cite?]
DOI: http://dx.doi.org/10.1002/hbm.22061
 
AbstractThe genes for the dopamine transporter (DAT) and the D-Amino acid oxidase activator (DAOA or G72) have been independently implicated in the risk for schizophrenia and in bipolar disorder and/or their related intermediate phenotypes. DAT and G72 respectively modulate central dopamine and glutamate transmission, the two systems most robustly implicated in these disorders. Contemporary studies have demonstrated that elevated dopamine function is associated with glutamatergic dysfunction in psychotic disorders. Using functional magnetic resonance imaging we examined whether there was an interaction between the effects of genes that influence dopamine and glutamate transmission (DAT and G72) on regional brain activation during verbal fluency, which is known to be abnormal in psychosis, in 80 healthy volunteers. Significant interactions between the effects of G72 and DAT polymorphisms on activation were evident in the striatum, parahippocampal gyrus, and supramarginal/angular gyri bilaterally, the right insula, in the right pre-/postcentral and the left posterior cingulate/retrosplenial gyri (P < 0.05, FDR-corrected across the whole brain). This provides evidence that interactions between the dopamine and the glutamate system, thought to be altered in psychosis, have an impact in executive processing which can be modulated by common genetic variation. © 2012 Wiley Periodicals, Inc.
 
ISSN1065-9471
2013 Impact Factor: 6.924
 
DOIhttp://dx.doi.org/10.1002/hbm.22061
 
DC FieldValue
dc.contributor.authorPauli, A
 
dc.contributor.authorPrata, DP
 
dc.contributor.authorMechelli, A
 
dc.contributor.authorPicchioni, M
 
dc.contributor.authorFu, CH
 
dc.contributor.authorChaddock, CA
 
dc.contributor.authorKane, F
 
dc.contributor.authorKalidindi, S
 
dc.contributor.authorMcdonald, C
 
dc.contributor.authorKravariti, E
 
dc.contributor.authorToulopoulou, T
 
dc.contributor.authorBramon, E
 
dc.contributor.authorWalshe, M
 
dc.contributor.authorEhlert, N
 
dc.contributor.authorGeorgiades, A
 
dc.contributor.authorMurray, R
 
dc.contributor.authorCollier, DA
 
dc.contributor.authorMcguire, P
 
dc.date.accessioned2012-08-23T06:11:30Z
 
dc.date.available2012-08-23T06:11:30Z
 
dc.date.issued2013
 
dc.description.abstractThe genes for the dopamine transporter (DAT) and the D-Amino acid oxidase activator (DAOA or G72) have been independently implicated in the risk for schizophrenia and in bipolar disorder and/or their related intermediate phenotypes. DAT and G72 respectively modulate central dopamine and glutamate transmission, the two systems most robustly implicated in these disorders. Contemporary studies have demonstrated that elevated dopamine function is associated with glutamatergic dysfunction in psychotic disorders. Using functional magnetic resonance imaging we examined whether there was an interaction between the effects of genes that influence dopamine and glutamate transmission (DAT and G72) on regional brain activation during verbal fluency, which is known to be abnormal in psychosis, in 80 healthy volunteers. Significant interactions between the effects of G72 and DAT polymorphisms on activation were evident in the striatum, parahippocampal gyrus, and supramarginal/angular gyri bilaterally, the right insula, in the right pre-/postcentral and the left posterior cingulate/retrosplenial gyri (P < 0.05, FDR-corrected across the whole brain). This provides evidence that interactions between the dopamine and the glutamate system, thought to be altered in psychosis, have an impact in executive processing which can be modulated by common genetic variation. © 2012 Wiley Periodicals, Inc.
 
dc.description.natureLink_to_subscribed_fulltext
 
dc.identifier.citationHuman Brain Mapping, 2013, v. 34 n. 9, p. 2244-2258 [How to Cite?]
DOI: http://dx.doi.org/10.1002/hbm.22061
 
dc.identifier.doihttp://dx.doi.org/10.1002/hbm.22061
 
dc.identifier.hkuros223340
 
dc.identifier.issn1065-9471
2013 Impact Factor: 6.924
 
dc.identifier.pmid22438288
 
dc.identifier.scopuseid_2-s2.0-84882682482
 
dc.identifier.urihttp://hdl.handle.net/10722/161256
 
dc.languageeng
 
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/38751
 
dc.publisher.placeUnited States
 
dc.relation.ispartofHuman Brain Mapping
 
dc.subjectDat
 
dc.subjectEpistasis
 
dc.subjectImaging Genetics
 
dc.subjectPsychosis, Daoa/G72
 
dc.subjectSchizophrenia
 
dc.subjectVerbal Fluency
 
dc.titleInteraction between effects of genes coding for dopamine and glutamate transmission on striatal and parahippocampal function
 
dc.typeArticle
 
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<contributor.author>Prata, DP</contributor.author>
<contributor.author>Mechelli, A</contributor.author>
<contributor.author>Picchioni, M</contributor.author>
<contributor.author>Fu, CH</contributor.author>
<contributor.author>Chaddock, CA</contributor.author>
<contributor.author>Kane, F</contributor.author>
<contributor.author>Kalidindi, S</contributor.author>
<contributor.author>Mcdonald, C</contributor.author>
<contributor.author>Kravariti, E</contributor.author>
<contributor.author>Toulopoulou, T</contributor.author>
<contributor.author>Bramon, E</contributor.author>
<contributor.author>Walshe, M</contributor.author>
<contributor.author>Ehlert, N</contributor.author>
<contributor.author>Georgiades, A</contributor.author>
<contributor.author>Murray, R</contributor.author>
<contributor.author>Collier, DA</contributor.author>
<contributor.author>Mcguire, P</contributor.author>
<date.accessioned>2012-08-23T06:11:30Z</date.accessioned>
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<date.issued>2013</date.issued>
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<description.abstract>The genes for the dopamine transporter (DAT) and the D-Amino acid oxidase activator (DAOA or G72) have been independently implicated in the risk for schizophrenia and in bipolar disorder and/or their related intermediate phenotypes. DAT and G72 respectively modulate central dopamine and glutamate transmission, the two systems most robustly implicated in these disorders. Contemporary studies have demonstrated that elevated dopamine function is associated with glutamatergic dysfunction in psychotic disorders. Using functional magnetic resonance imaging we examined whether there was an interaction between the effects of genes that influence dopamine and glutamate transmission (DAT and G72) on regional brain activation during verbal fluency, which is known to be abnormal in psychosis, in 80 healthy volunteers. Significant interactions between the effects of G72 and DAT polymorphisms on activation were evident in the striatum, parahippocampal gyrus, and supramarginal/angular gyri bilaterally, the right insula, in the right pre-/postcentral and the left posterior cingulate/retrosplenial gyri (P &lt; 0.05, FDR-corrected across the whole brain). This provides evidence that interactions between the dopamine and the glutamate system, thought to be altered in psychosis, have an impact in executive processing which can be modulated by common genetic variation. &#169; 2012 Wiley Periodicals, Inc.</description.abstract>
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<subject>Dat</subject>
<subject>Epistasis</subject>
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<subject>Verbal Fluency</subject>
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Author Affiliations
  1. King's College London
  2. UniversitätsSpital Bern
  3. National University of Ireland Galway