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Article: Theory of Mind as a potential trait marker of schizophrenia: A family study

TitleTheory of Mind as a potential trait marker of schizophrenia: A family study
Authors
Issue Date2012
PublisherPsychology Press. The Journal's web site is located at http://www.tandf.co.uk/journals/titles/13546805.asp
Citation
Cognitive Neuropsychiatry, 2012, v. 17 n. 1, p. 64-89 How to Cite?
AbstractIntroduction. Although there is some evidence that Theory of Mind (ToM) deficits may be trait markers of schizophrenia it is not clear yet if ToM deficits are primary deficits, that is, to be independent of deficits in general intellectual abilities and executive function. The aim was to examine if ToM deficits may be trait markers of the illness and the effect of cognitive inhibition, general intellectual abilities and depression on ToM abilities of patients with schizophrenia and their unaffected parents. Methods. We assessed ToM abilities (first-order and second-order ToM stories, The Revised Eyes Test), cognitive inhibition (Stroop Task), general intellectual ability (Standard Progressive Matrices Test Plus) in patients with schizophrenia (N=21) and their unaffected fathers (N=21) and mothers (N=21) in comparison with healthy control families (healthy control males, N=21, healthy control fathers, N=21, healthy control mothers, N=21) Results. Patients showed deficits in first-order ToM tasks but some of these deficits were mediated by general intellectual abilities. Impairments in cognitive inhibition mediated only patients performance in The Revised Eyes Test. Patients showed deficits in second-order ToM stories independently of deficits in general intellectual abilities and cognitive inhibition. Unaffected parents did not show deficits in first-order ToM tasks, whereas they showed deficits in second-order ToM stories. However, the deficits that unaffected parents showed in second-order ToM stories were mediated by their deficits in general intellectual abilities, and there was an effect of remitted depression on the unaffected mothers performance. Conclusions. The results suggest that intact neurocognitive and general intellectual abilities are necessary in order patients and their unaffected parents to pass successfully ToM tasks. Patients and their unaffected parents show ToM deficits but these deficits are not similar. Patients show ToM deficits but these deficits seem to be a component of the pathophysiology of the illness (e.g., deficits in executive function, general intellectual abilities). © 2012 Copyright Psychology Press Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/161254
ISSN
2015 Impact Factor: 1.924
2015 SCImago Journal Rankings: 1.024
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorPentaraki, ADen_US
dc.contributor.authorStefanis, NCen_US
dc.contributor.authorStahl, Den_US
dc.contributor.authorTheleritis, Cen_US
dc.contributor.authorToulopoulou, Ten_US
dc.contributor.authorRoukas, Den_US
dc.contributor.authorKaliora, SCen_US
dc.contributor.authorChatzimanolis, Ien_US
dc.contributor.authorSmyrnis, Nen_US
dc.contributor.authorRussell, Ten_US
dc.contributor.authorKravariti, Een_US
dc.contributor.authorMurray, RMen_US
dc.date.accessioned2012-08-23T06:11:28Z-
dc.date.available2012-08-23T06:11:28Z-
dc.date.issued2012en_US
dc.identifier.citationCognitive Neuropsychiatry, 2012, v. 17 n. 1, p. 64-89en_US
dc.identifier.issn1354-6805en_US
dc.identifier.urihttp://hdl.handle.net/10722/161254-
dc.description.abstractIntroduction. Although there is some evidence that Theory of Mind (ToM) deficits may be trait markers of schizophrenia it is not clear yet if ToM deficits are primary deficits, that is, to be independent of deficits in general intellectual abilities and executive function. The aim was to examine if ToM deficits may be trait markers of the illness and the effect of cognitive inhibition, general intellectual abilities and depression on ToM abilities of patients with schizophrenia and their unaffected parents. Methods. We assessed ToM abilities (first-order and second-order ToM stories, The Revised Eyes Test), cognitive inhibition (Stroop Task), general intellectual ability (Standard Progressive Matrices Test Plus) in patients with schizophrenia (N=21) and their unaffected fathers (N=21) and mothers (N=21) in comparison with healthy control families (healthy control males, N=21, healthy control fathers, N=21, healthy control mothers, N=21) Results. Patients showed deficits in first-order ToM tasks but some of these deficits were mediated by general intellectual abilities. Impairments in cognitive inhibition mediated only patients performance in The Revised Eyes Test. Patients showed deficits in second-order ToM stories independently of deficits in general intellectual abilities and cognitive inhibition. Unaffected parents did not show deficits in first-order ToM tasks, whereas they showed deficits in second-order ToM stories. However, the deficits that unaffected parents showed in second-order ToM stories were mediated by their deficits in general intellectual abilities, and there was an effect of remitted depression on the unaffected mothers performance. Conclusions. The results suggest that intact neurocognitive and general intellectual abilities are necessary in order patients and their unaffected parents to pass successfully ToM tasks. Patients and their unaffected parents show ToM deficits but these deficits are not similar. Patients show ToM deficits but these deficits seem to be a component of the pathophysiology of the illness (e.g., deficits in executive function, general intellectual abilities). © 2012 Copyright Psychology Press Ltd.en_US
dc.languageengen_US
dc.publisherPsychology Press. The Journal's web site is located at http://www.tandf.co.uk/journals/titles/13546805.aspen_US
dc.relation.ispartofCognitive Neuropsychiatryen_US
dc.subject.meshAdulten_US
dc.subject.meshAntipsychotic Agents - Therapeutic Useen_US
dc.subject.meshCognition - Physiologyen_US
dc.subject.meshDepressive Disorder, Major - Psychologyen_US
dc.subject.meshDiagnostic And Statistical Manual Of Mental Disordersen_US
dc.subject.meshFamilyen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshIntelligence Testsen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshNeuropsychological Testsen_US
dc.subject.meshPsychiatric Status Rating Scalesen_US
dc.subject.meshQuestionnairesen_US
dc.subject.meshRepression, Psychologyen_US
dc.subject.meshSample Sizeen_US
dc.subject.meshSchizophrenia - Complications - Drug Therapy - Geneticsen_US
dc.subject.meshSchizophrenic Psychologyen_US
dc.subject.meshStroop Testen_US
dc.subject.meshTheory Of Mind - Physiologyen_US
dc.subject.meshYoung Adulten_US
dc.titleTheory of Mind as a potential trait marker of schizophrenia: A family studyen_US
dc.typeArticleen_US
dc.identifier.emailToulopoulou, T:timothea@hku.hken_US
dc.identifier.authorityToulopoulou, T=rp01542en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1080/13546805.2011.568289en_US
dc.identifier.pmid22216944-
dc.identifier.scopuseid_2-s2.0-84856342555en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-84856342555&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume17en_US
dc.identifier.issue1en_US
dc.identifier.spage64en_US
dc.identifier.epage89en_US
dc.identifier.isiWOS:000304254100004-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridPentaraki, AD=54929834300en_US
dc.identifier.scopusauthoridStefanis, NC=54930127700en_US
dc.identifier.scopusauthoridStahl, D=23669226600en_US
dc.identifier.scopusauthoridTheleritis, C=6507325072en_US
dc.identifier.scopusauthoridToulopoulou, T=8855468700en_US
dc.identifier.scopusauthoridRoukas, D=6504403630en_US
dc.identifier.scopusauthoridKaliora, SC=54929834400en_US
dc.identifier.scopusauthoridChatzimanolis, I=25224637400en_US
dc.identifier.scopusauthoridSmyrnis, N=7004551120en_US
dc.identifier.scopusauthoridRussell, T=10038820000en_US
dc.identifier.scopusauthoridKravariti, E=8855469000en_US
dc.identifier.scopusauthoridMurray, RM=35406239400en_US

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