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Article: Prefrontal and striatal volumes in monozygotic twins concordant and discordant for schizophrenia

TitlePrefrontal and striatal volumes in monozygotic twins concordant and discordant for schizophrenia
Authors
Issue Date2012
PublisherOxford University Press. The Journal's web site is located at http://schizophreniabulletin.oxfordjournals.org/
Citation
Schizophrenia Bulletin, 2012, v. 38 n. 1, p. 192-203 How to Cite?
AbstractFrontostriatal networks mediating important cognitive and motor functions have been shown to be abnormal structurally and functionally in schizophrenia. However, the influence of genetic risk for schizophrenia on structural abnormalities in these areas is not well established. This study therefore aimed to investigate prefrontal and striatal volume alterations in schizophrenia and to define the extent to which they are dependent on genetic vulnerability for the condition. We employed structural magnetic resonance imaging (sMRI) in monozygotic (MZ) twins with or without schizophrenia. A sample of 129 twins completed sMRI, consisting of 21 MZ twin pairs concordant for schizophrenia, 17 MZ schizophrenic twins and 18 MZ nonschizophrenic twins drawn from 19 pairs discordant for schizophrenia, and 26 MZ control twin pairs without schizophrenia. Groups did not significantly differ in age, gender, handedness, height, level of education, parental socioeconomic status, and ethnicity. Using a region-of-interest approach, we measured the gray matter volumes (in cm 3) of superior, middle, inferior, and orbital frontal cortices (SFC, MFC, IFC, and OFC, respectively); the caudate; and putamen. Covarying for whole-brain volume, age, and gender, we found that concordant but not discordant twins with schizophrenia had significantly lower volumes of MFC and OFC than control twins. In contrast, both patient groups had significantly lower SFC volumes than both groups of nonschizophrenic twins. There were no significant group differences in IFC and the striatum. We conclude that the prefrontal cortex shows a heterogeneous pattern of genetic influences on volumetric reductions in schizophrenia. © 2011 The Author.
Persistent Identifierhttp://hdl.handle.net/10722/161253
ISSN
2015 Impact Factor: 7.757
2015 SCImago Journal Rankings: 4.051
PubMed Central ID
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorEttinger, Uen_US
dc.contributor.authorSchmechtig, Aen_US
dc.contributor.authorToulopoulou, Ten_US
dc.contributor.authorBorg, Cen_US
dc.contributor.authorOrrells, Cen_US
dc.contributor.authorOwens, Sen_US
dc.contributor.authorMatsumoto, Ken_US
dc.contributor.authorVan Haren, NEen_US
dc.contributor.authorHall, MHen_US
dc.contributor.authorKumari, Ven_US
dc.contributor.authorMcguire, PKen_US
dc.contributor.authorMurray, RMen_US
dc.contributor.authorPicchioni, Men_US
dc.date.accessioned2012-08-23T06:11:28Z-
dc.date.available2012-08-23T06:11:28Z-
dc.date.issued2012en_US
dc.identifier.citationSchizophrenia Bulletin, 2012, v. 38 n. 1, p. 192-203en_US
dc.identifier.issn0586-7614en_US
dc.identifier.urihttp://hdl.handle.net/10722/161253-
dc.description.abstractFrontostriatal networks mediating important cognitive and motor functions have been shown to be abnormal structurally and functionally in schizophrenia. However, the influence of genetic risk for schizophrenia on structural abnormalities in these areas is not well established. This study therefore aimed to investigate prefrontal and striatal volume alterations in schizophrenia and to define the extent to which they are dependent on genetic vulnerability for the condition. We employed structural magnetic resonance imaging (sMRI) in monozygotic (MZ) twins with or without schizophrenia. A sample of 129 twins completed sMRI, consisting of 21 MZ twin pairs concordant for schizophrenia, 17 MZ schizophrenic twins and 18 MZ nonschizophrenic twins drawn from 19 pairs discordant for schizophrenia, and 26 MZ control twin pairs without schizophrenia. Groups did not significantly differ in age, gender, handedness, height, level of education, parental socioeconomic status, and ethnicity. Using a region-of-interest approach, we measured the gray matter volumes (in cm 3) of superior, middle, inferior, and orbital frontal cortices (SFC, MFC, IFC, and OFC, respectively); the caudate; and putamen. Covarying for whole-brain volume, age, and gender, we found that concordant but not discordant twins with schizophrenia had significantly lower volumes of MFC and OFC than control twins. In contrast, both patient groups had significantly lower SFC volumes than both groups of nonschizophrenic twins. There were no significant group differences in IFC and the striatum. We conclude that the prefrontal cortex shows a heterogeneous pattern of genetic influences on volumetric reductions in schizophrenia. © 2011 The Author.en_US
dc.languageengen_US
dc.publisherOxford University Press. The Journal's web site is located at http://schizophreniabulletin.oxfordjournals.org/en_US
dc.relation.ispartofSchizophrenia Bulletinen_US
dc.subject.meshAdulten_US
dc.subject.meshCase-Control Studiesen_US
dc.subject.meshCaudate Nucleus - Anatomy & Histologyen_US
dc.subject.meshCorpus Striatum - Anatomy & Histologyen_US
dc.subject.meshDiseases In Twinsen_US
dc.subject.meshFemaleen_US
dc.subject.meshFrontal Lobe - Anatomy & Histologyen_US
dc.subject.meshGenetic Predisposition To Diseaseen_US
dc.subject.meshHumansen_US
dc.subject.meshMagnetic Resonance Imagingen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshOrgan Sizeen_US
dc.subject.meshPrefrontal Cortex - Anatomy & Histologyen_US
dc.subject.meshPutamen - Anatomy & Histologyen_US
dc.subject.meshSchizophrenia - Genetics - Physiopathologyen_US
dc.subject.meshTwins, Monozygotic - Genetics - Psychologyen_US
dc.titlePrefrontal and striatal volumes in monozygotic twins concordant and discordant for schizophreniaen_US
dc.typeArticleen_US
dc.identifier.emailToulopoulou, T:timothea@hku.hken_US
dc.identifier.authorityToulopoulou, T=rp01542en_US
dc.description.naturelink_to_OA_fulltexten_US
dc.identifier.doi10.1093/schbul/sbq060en_US
dc.identifier.pmid20538831-
dc.identifier.pmcidPMC3245600-
dc.identifier.scopuseid_2-s2.0-84555177855en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-84555177855&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume38en_US
dc.identifier.issue1en_US
dc.identifier.spage192en_US
dc.identifier.epage203en_US
dc.identifier.isiWOS:000299011900023-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridEttinger, U=6602766172en_US
dc.identifier.scopusauthoridSchmechtig, A=26646923700en_US
dc.identifier.scopusauthoridToulopoulou, T=8855468700en_US
dc.identifier.scopusauthoridBorg, C=54794846400en_US
dc.identifier.scopusauthoridOrrells, C=54795724700en_US
dc.identifier.scopusauthoridOwens, S=36027261600en_US
dc.identifier.scopusauthoridMatsumoto, K=7601610506en_US
dc.identifier.scopusauthoridVan Haren, NE=6603501057en_US
dc.identifier.scopusauthoridHall, MH=14013171900en_US
dc.identifier.scopusauthoridKumari, V=7005573217en_US
dc.identifier.scopusauthoridMcGuire, PK=7101880438en_US
dc.identifier.scopusauthoridMurray, RM=35406239400en_US
dc.identifier.scopusauthoridPicchioni, M=6507443795en_US

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