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Article: Effect of D-amino acid oxidase activator (DAOA; G72) on brain function during verbal fluency
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TitleEffect of D-amino acid oxidase activator (DAOA; G72) on brain function during verbal fluency
 
AuthorsPrata, DP2 2
Papagni, SA2 4
Mechelli, A2 2
Fu, CH2
Kambeitz, J2 1
Picchioni, M2 3
Kane, F2
Kalidindi, S2
Mcdonald, C3
Kravariti, E2
Toulopoulou, T2
Bramon, E2
Walshe, M2
Murray, R2
Collier, DA2
Mcguire, PK2
 
Issue Date2012
 
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/38751
 
CitationHuman Brain Mapping, 2012, v. 33 n. 1, p. 143-153 [How to Cite?]
DOI: http://dx.doi.org/10.1002/hbm.21198
 
AbstractBackground. The D-Amino acid oxidase activator (G72 or DAOA) is believed to play a key role in the regulation of central glutamatergic transmission which is seen to be altered in psychosis. It is thought to regulate D-amino acid oxidase (DAO), which metabolizes D-serine, a co-agonist of NMDA-type glutamate receptors and to be involved in dendritic arborization. Linkage, genetic association and expression studies have implicated the G72 gene in both schizophrenia and bipolar disorder. Aims. To examine the influence of G72 variation on brain function in the healthy population. Method. Fifty healthy volunteers were assessed using functional magnetic resonance imaging while performing a verbal fluency task. Regional brain activation and task-dependent functional connectivity during word generation was compared between different rs746187 genotypes. Results. G72 rs746187 genotype had a significant effect on activation in the left postcentral and supramarginal gyri (FWE P < 0.05), and on the task-dependent functional coupling of this region with the retrosplenial cingulate gyrus (FWE P < 0.05). Conclusions. Our results may reflect an effect of G72 on glutamatergic transmission, mediated by an influence on D-amino acid oxidase activity, on brain areas particularly relevant to the hypoglutamatergic model of psychosis. © 2011 Wiley Periodicals, Inc.
 
ISSN1065-9471
2012 Impact Factor: 6.878
2012 SCImago Journal Rankings: 3.002
 
DOIhttp://dx.doi.org/10.1002/hbm.21198
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorPrata, DP
 
dc.contributor.authorPapagni, SA
 
dc.contributor.authorMechelli, A
 
dc.contributor.authorFu, CH
 
dc.contributor.authorKambeitz, J
 
dc.contributor.authorPicchioni, M
 
dc.contributor.authorKane, F
 
dc.contributor.authorKalidindi, S
 
dc.contributor.authorMcdonald, C
 
dc.contributor.authorKravariti, E
 
dc.contributor.authorToulopoulou, T
 
dc.contributor.authorBramon, E
 
dc.contributor.authorWalshe, M
 
dc.contributor.authorMurray, R
 
dc.contributor.authorCollier, DA
 
dc.contributor.authorMcguire, PK
 
dc.date.accessioned2012-08-23T06:11:27Z
 
dc.date.available2012-08-23T06:11:27Z
 
dc.date.issued2012
 
dc.description.abstractBackground. The D-Amino acid oxidase activator (G72 or DAOA) is believed to play a key role in the regulation of central glutamatergic transmission which is seen to be altered in psychosis. It is thought to regulate D-amino acid oxidase (DAO), which metabolizes D-serine, a co-agonist of NMDA-type glutamate receptors and to be involved in dendritic arborization. Linkage, genetic association and expression studies have implicated the G72 gene in both schizophrenia and bipolar disorder. Aims. To examine the influence of G72 variation on brain function in the healthy population. Method. Fifty healthy volunteers were assessed using functional magnetic resonance imaging while performing a verbal fluency task. Regional brain activation and task-dependent functional connectivity during word generation was compared between different rs746187 genotypes. Results. G72 rs746187 genotype had a significant effect on activation in the left postcentral and supramarginal gyri (FWE P < 0.05), and on the task-dependent functional coupling of this region with the retrosplenial cingulate gyrus (FWE P < 0.05). Conclusions. Our results may reflect an effect of G72 on glutamatergic transmission, mediated by an influence on D-amino acid oxidase activity, on brain areas particularly relevant to the hypoglutamatergic model of psychosis. © 2011 Wiley Periodicals, Inc.
 
dc.description.natureLink_to_subscribed_fulltext
 
dc.identifier.citationHuman Brain Mapping, 2012, v. 33 n. 1, p. 143-153 [How to Cite?]
DOI: http://dx.doi.org/10.1002/hbm.21198
 
dc.identifier.doihttp://dx.doi.org/10.1002/hbm.21198
 
dc.identifier.epage153
 
dc.identifier.issn1065-9471
2012 Impact Factor: 6.878
2012 SCImago Journal Rankings: 3.002
 
dc.identifier.issue1
 
dc.identifier.pmid21391259
 
dc.identifier.scopuseid_2-s2.0-83455199102
 
dc.identifier.spage143
 
dc.identifier.urihttp://hdl.handle.net/10722/161252
 
dc.identifier.volume33
 
dc.languageeng
 
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/38751
 
dc.publisher.placeUnited States
 
dc.relation.ispartofHuman Brain Mapping
 
dc.relation.referencesReferences in Scopus
 
dc.subject.meshAdult
 
dc.subject.meshBrain - Physiology
 
dc.subject.meshBrain Mapping
 
dc.subject.meshCarrier Proteins - Genetics
 
dc.subject.meshFemale
 
dc.subject.meshGenotype
 
dc.subject.meshGlutamic Acid - Metabolism
 
dc.subject.meshHumans
 
dc.subject.meshMagnetic Resonance Imaging
 
dc.subject.meshMale
 
dc.subject.meshMiddle Aged
 
dc.subject.meshNerve Net - Physiology
 
dc.subject.meshNeuroimaging
 
dc.subject.meshPolymorphism, Single Nucleotide
 
dc.subject.meshVerbal Behavior - Physiology
 
dc.titleEffect of D-amino acid oxidase activator (DAOA; G72) on brain function during verbal fluency
 
dc.typeArticle
 
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<description.abstract>Background. The D-Amino acid oxidase activator (G72 or DAOA) is believed to play a key role in the regulation of central glutamatergic transmission which is seen to be altered in psychosis. It is thought to regulate D-amino acid oxidase (DAO), which metabolizes D-serine, a co-agonist of NMDA-type glutamate receptors and to be involved in dendritic arborization. Linkage, genetic association and expression studies have implicated the G72 gene in both schizophrenia and bipolar disorder. Aims. To examine the influence of G72 variation on brain function in the healthy population. Method. Fifty healthy volunteers were assessed using functional magnetic resonance imaging while performing a verbal fluency task. Regional brain activation and task-dependent functional connectivity during word generation was compared between different rs746187 genotypes. Results. G72 rs746187 genotype had a significant effect on activation in the left postcentral and supramarginal gyri (FWE P &lt; 0.05), and on the task-dependent functional coupling of this region with the retrosplenial cingulate gyrus (FWE P &lt; 0.05). Conclusions. Our results may reflect an effect of G72 on glutamatergic transmission, mediated by an influence on D-amino acid oxidase activity, on brain areas particularly relevant to the hypoglutamatergic model of psychosis. &#169; 2011 Wiley Periodicals, Inc.</description.abstract>
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Author Affiliations
  1. Ludwig-Maximilians-Universität München
  2. King's College London
  3. National University of Ireland
  4. Università degli Studi di Foggia