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Article: Effect of D-amino acid oxidase activator (DAOA; G72) on brain function during verbal fluency

TitleEffect of D-amino acid oxidase activator (DAOA; G72) on brain function during verbal fluency
Authors
Issue Date2012
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/38751
Citation
Human Brain Mapping, 2012, v. 33 n. 1, p. 143-153 How to Cite?
AbstractBackground. The D-Amino acid oxidase activator (G72 or DAOA) is believed to play a key role in the regulation of central glutamatergic transmission which is seen to be altered in psychosis. It is thought to regulate D-amino acid oxidase (DAO), which metabolizes D-serine, a co-agonist of NMDA-type glutamate receptors and to be involved in dendritic arborization. Linkage, genetic association and expression studies have implicated the G72 gene in both schizophrenia and bipolar disorder. Aims. To examine the influence of G72 variation on brain function in the healthy population. Method. Fifty healthy volunteers were assessed using functional magnetic resonance imaging while performing a verbal fluency task. Regional brain activation and task-dependent functional connectivity during word generation was compared between different rs746187 genotypes. Results. G72 rs746187 genotype had a significant effect on activation in the left postcentral and supramarginal gyri (FWE P < 0.05), and on the task-dependent functional coupling of this region with the retrosplenial cingulate gyrus (FWE P < 0.05). Conclusions. Our results may reflect an effect of G72 on glutamatergic transmission, mediated by an influence on D-amino acid oxidase activity, on brain areas particularly relevant to the hypoglutamatergic model of psychosis. © 2011 Wiley Periodicals, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/161252
ISSN
2014 Impact Factor: 5.969
2014 SCImago Journal Rankings: 2.535
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorPrata, DPen_US
dc.contributor.authorPapagni, SAen_US
dc.contributor.authorMechelli, Aen_US
dc.contributor.authorFu, CHen_US
dc.contributor.authorKambeitz, Jen_US
dc.contributor.authorPicchioni, Men_US
dc.contributor.authorKane, Fen_US
dc.contributor.authorKalidindi, Sen_US
dc.contributor.authorMcdonald, Cen_US
dc.contributor.authorKravariti, Een_US
dc.contributor.authorToulopoulou, Ten_US
dc.contributor.authorBramon, Een_US
dc.contributor.authorWalshe, Men_US
dc.contributor.authorMurray, Ren_US
dc.contributor.authorCollier, DAen_US
dc.contributor.authorMcguire, PKen_US
dc.date.accessioned2012-08-23T06:11:27Z-
dc.date.available2012-08-23T06:11:27Z-
dc.date.issued2012en_US
dc.identifier.citationHuman Brain Mapping, 2012, v. 33 n. 1, p. 143-153en_US
dc.identifier.issn1065-9471en_US
dc.identifier.urihttp://hdl.handle.net/10722/161252-
dc.description.abstractBackground. The D-Amino acid oxidase activator (G72 or DAOA) is believed to play a key role in the regulation of central glutamatergic transmission which is seen to be altered in psychosis. It is thought to regulate D-amino acid oxidase (DAO), which metabolizes D-serine, a co-agonist of NMDA-type glutamate receptors and to be involved in dendritic arborization. Linkage, genetic association and expression studies have implicated the G72 gene in both schizophrenia and bipolar disorder. Aims. To examine the influence of G72 variation on brain function in the healthy population. Method. Fifty healthy volunteers were assessed using functional magnetic resonance imaging while performing a verbal fluency task. Regional brain activation and task-dependent functional connectivity during word generation was compared between different rs746187 genotypes. Results. G72 rs746187 genotype had a significant effect on activation in the left postcentral and supramarginal gyri (FWE P < 0.05), and on the task-dependent functional coupling of this region with the retrosplenial cingulate gyrus (FWE P < 0.05). Conclusions. Our results may reflect an effect of G72 on glutamatergic transmission, mediated by an influence on D-amino acid oxidase activity, on brain areas particularly relevant to the hypoglutamatergic model of psychosis. © 2011 Wiley Periodicals, Inc.en_US
dc.languageengen_US
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/38751en_US
dc.relation.ispartofHuman Brain Mappingen_US
dc.subject.meshAdulten_US
dc.subject.meshBrain - Physiologyen_US
dc.subject.meshBrain Mappingen_US
dc.subject.meshCarrier Proteins - Geneticsen_US
dc.subject.meshFemaleen_US
dc.subject.meshGenotypeen_US
dc.subject.meshGlutamic Acid - Metabolismen_US
dc.subject.meshHumansen_US
dc.subject.meshMagnetic Resonance Imagingen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshNerve Net - Physiologyen_US
dc.subject.meshNeuroimagingen_US
dc.subject.meshPolymorphism, Single Nucleotideen_US
dc.subject.meshVerbal Behavior - Physiologyen_US
dc.titleEffect of D-amino acid oxidase activator (DAOA; G72) on brain function during verbal fluencyen_US
dc.typeArticleen_US
dc.identifier.emailToulopoulou, T:timothea@hku.hken_US
dc.identifier.authorityToulopoulou, T=rp01542en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1002/hbm.21198en_US
dc.identifier.pmid21391259en_US
dc.identifier.scopuseid_2-s2.0-83455199102en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-83455199102&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume33en_US
dc.identifier.issue1en_US
dc.identifier.spage143en_US
dc.identifier.epage153en_US
dc.identifier.isiWOS:000298591100012-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridPrata, DP=14632352500en_US
dc.identifier.scopusauthoridPapagni, SA=6506721202en_US
dc.identifier.scopusauthoridMechelli, A=6603693131en_US
dc.identifier.scopusauthoridFu, CH=8502155300en_US
dc.identifier.scopusauthoridKambeitz, J=36790051100en_US
dc.identifier.scopusauthoridPicchioni, M=6507443795en_US
dc.identifier.scopusauthoridKane, F=24829114900en_US
dc.identifier.scopusauthoridKalidindi, S=24366595400en_US
dc.identifier.scopusauthoridMcdonald, C=8749594800en_US
dc.identifier.scopusauthoridKravariti, E=8855469000en_US
dc.identifier.scopusauthoridToulopoulou, T=8855468700en_US
dc.identifier.scopusauthoridBramon, E=8089378900en_US
dc.identifier.scopusauthoridWalshe, M=8855469300en_US
dc.identifier.scopusauthoridMurray, R=35406239400en_US
dc.identifier.scopusauthoridCollier, DA=26642980600en_US
dc.identifier.scopusauthoridMcguire, PK=7101880438en_US

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