Article: Effect of D-amino acid oxidase activator (DAOA; G72) on brain function during verbal fluency

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TitleEffect of D-amino acid oxidase activator (DAOA; G72) on brain function during verbal fluency
AuthorsPrata, DP2
Papagni, SA2 4
Mechelli, A2
Fu, CH2
Kambeitz, J1 2
Picchioni, M2 3
Kane, F2
Kalidindi, S2
Mcdonald, C3
Kravariti, E2
Toulopoulou, T2
Bramon, E2
Walshe, M2
Murray, R2
Collier, DA2
Mcguire, PK2
Issue Date2012
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/38751
CitationHuman Brain Mapping, 2012, v. 33 n. 1, p. 143-153 [How to Cite?]
DOI: http://dx.doi.org/10.1002/hbm.21198
AbstractBackground. The D-Amino acid oxidase activator (G72 or DAOA) is believed to play a key role in the regulation of central glutamatergic transmission which is seen to be altered in psychosis. It is thought to regulate D-amino acid oxidase (DAO), which metabolizes D-serine, a co-agonist of NMDA-type glutamate receptors and to be involved in dendritic arborization. Linkage, genetic association and expression studies have implicated the G72 gene in both schizophrenia and bipolar disorder. Aims. To examine the influence of G72 variation on brain function in the healthy population. Method. Fifty healthy volunteers were assessed using functional magnetic resonance imaging while performing a verbal fluency task. Regional brain activation and task-dependent functional connectivity during word generation was compared between different rs746187 genotypes. Results. G72 rs746187 genotype had a significant effect on activation in the left postcentral and supramarginal gyri (FWE P < 0.05), and on the task-dependent functional coupling of this region with the retrosplenial cingulate gyrus (FWE P < 0.05). Conclusions. Our results may reflect an effect of G72 on glutamatergic transmission, mediated by an influence on D-amino acid oxidase activity, on brain areas particularly relevant to the hypoglutamatergic model of psychosis. © 2011 Wiley Periodicals, Inc.
ISSN1065-9471
2011 Impact Factor: 5.88
2011 SCImago Journal Rankings: 0.416
DOIhttp://dx.doi.org/10.1002/hbm.21198
ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorPrata, DP
dc.contributor.authorPapagni, SA
dc.contributor.authorMechelli, A
dc.contributor.authorFu, CH
dc.contributor.authorKambeitz, J
dc.contributor.authorPicchioni, M
dc.contributor.authorKane, F
dc.contributor.authorKalidindi, S
dc.contributor.authorMcdonald, C
dc.contributor.authorKravariti, E
dc.contributor.authorToulopoulou, T
dc.contributor.authorBramon, E
dc.contributor.authorWalshe, M
dc.contributor.authorMurray, R
dc.contributor.authorCollier, DA
dc.contributor.authorMcguire, PK
dc.date.accessioned2012-08-23T06:11:27Z
dc.date.available2012-08-23T06:11:27Z
dc.date.issued2012
dc.description.abstractBackground. The D-Amino acid oxidase activator (G72 or DAOA) is believed to play a key role in the regulation of central glutamatergic transmission which is seen to be altered in psychosis. It is thought to regulate D-amino acid oxidase (DAO), which metabolizes D-serine, a co-agonist of NMDA-type glutamate receptors and to be involved in dendritic arborization. Linkage, genetic association and expression studies have implicated the G72 gene in both schizophrenia and bipolar disorder. Aims. To examine the influence of G72 variation on brain function in the healthy population. Method. Fifty healthy volunteers were assessed using functional magnetic resonance imaging while performing a verbal fluency task. Regional brain activation and task-dependent functional connectivity during word generation was compared between different rs746187 genotypes. Results. G72 rs746187 genotype had a significant effect on activation in the left postcentral and supramarginal gyri (FWE P < 0.05), and on the task-dependent functional coupling of this region with the retrosplenial cingulate gyrus (FWE P < 0.05). Conclusions. Our results may reflect an effect of G72 on glutamatergic transmission, mediated by an influence on D-amino acid oxidase activity, on brain areas particularly relevant to the hypoglutamatergic model of psychosis. © 2011 Wiley Periodicals, Inc.
dc.description.natureLink_to_subscribed_fulltext
dc.identifier.citationHuman Brain Mapping, 2012, v. 33 n. 1, p. 143-153 [How to Cite?]
DOI: http://dx.doi.org/10.1002/hbm.21198
dc.identifier.doihttp://dx.doi.org/10.1002/hbm.21198
dc.identifier.epage153
dc.identifier.issn1065-9471
2011 Impact Factor: 5.88
2011 SCImago Journal Rankings: 0.416
dc.identifier.issue1
dc.identifier.pmid21391259
dc.identifier.scopuseid_2-s2.0-83455199102
dc.identifier.spage143
dc.identifier.urihttp://hdl.handle.net/10722/161252
dc.identifier.volume33
dc.languageeng
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/38751
dc.publisher.placeUnited States
dc.relation.ispartofHuman Brain Mapping
dc.relation.referencesReferences in Scopus
dc.subject.meshAdult
dc.subject.meshBrain - Physiology
dc.subject.meshBrain Mapping
dc.subject.meshCarrier Proteins - Genetics
dc.subject.meshFemale
dc.subject.meshGenotype
dc.subject.meshGlutamic Acid - Metabolism
dc.subject.meshHumans
dc.subject.meshMagnetic Resonance Imaging
dc.subject.meshMale
dc.subject.meshMiddle Aged
dc.subject.meshNerve Net - Physiology
dc.subject.meshNeuroimaging
dc.subject.meshPolymorphism, Single Nucleotide
dc.subject.meshVerbal Behavior - Physiology
dc.titleEffect of D-amino acid oxidase activator (DAOA; G72) on brain function during verbal fluency
dc.typeArticle
Author Affiliations
  1. Ludwig-Maximilians-Universität München
  2. King's College London
  3. National University of Ireland
  4. Università degli Studi di Foggia